Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
<p dir="ltr">Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years, the applicati...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513553304649728 |
|---|---|
| author | Kalyani Patil (2679424) |
| author2 | Shilpa Kuttikrishnan (3520079) Abdul Q. Khan (14153247) Fareed Ahmad (134672) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| author2_role | author author author author author author author author |
| author_facet | Kalyani Patil (2679424) Shilpa Kuttikrishnan (3520079) Abdul Q. Khan (14153247) Fareed Ahmad (134672) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kalyani Patil (2679424) Shilpa Kuttikrishnan (3520079) Abdul Q. Khan (14153247) Fareed Ahmad (134672) Majid Alam (14158959) Joerg Buddenkotte (6293584) Aamir Ahmad (233201) Martin Steinhoff (5340194) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2022-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2021.12.003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Molecular_pathogenesis_of_Cutaneous_T_cell_Lymphoma_Role_of_chemokines_cytokines_and_dysregulated_signaling_pathways/24311911 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Cutaneous T cell lymphoma Chemokines Cytokines Signaling pathways Sezary syndrome Mycosis fungoides Pathophysiology |
| dc.title.none.fl_str_mv | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years, the application of next-generation sequencing (NGS) has evolved our understanding of the pathogenetic mechanisms, including genetic aberrations and epigenetic abnormalities that shape the mutational landscape of CTCL and represent one of the important pro-tumorigenic principles in CTCL initiation and progression. Still, identification of the major pathophysiological pathways including genetic and epigenetic components that mediate malignant clonal T cell expansion has not been achieved. This is of prime importance given the role of malignant T cell clones in fostering T helper 2 (Th2)-bias tumor microenvironment and fueling progressive immune dysregulation and tumor cell growth in CTCL patients, manifested by the secretion of Th2-associated cytokines and chemokines. Alterations in malignant cytokine and chemokine expression patterns orchestrate the inflammatory milieu and influence the migration dynamics of malignant clonal T cells. Here, we highlight recent insights about the molecular mechanisms of CTCL pathogenesis, emphasizing the role of cytokines, chemokines, and associated downstream signaling networks in driving immune defects, malignant transformation, and disease progression. In-depth characterization of the CTCL immunophenotype and tumoral microenvironment offers a facile opportunity to expand the therapeutic armamentarium of CTCL, an intractable malignant skin disease with poor prognosis and in dire need of curative treatment approaches.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2021.12.003" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2021.12.003</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_50a698f1d8d53a6fc821f14aa614eea3 |
| identifier_str_mv | 10.1016/j.semcancer.2021.12.003 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24311911 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathwaysKalyani Patil (2679424)Shilpa Kuttikrishnan (3520079)Abdul Q. Khan (14153247)Fareed Ahmad (134672)Majid Alam (14158959)Joerg Buddenkotte (6293584)Aamir Ahmad (233201)Martin Steinhoff (5340194)Shahab Uddin (154400)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesisCutaneous T cell lymphomaChemokinesCytokinesSignaling pathwaysSezary syndromeMycosis fungoidesPathophysiology<p dir="ltr">Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years, the application of next-generation sequencing (NGS) has evolved our understanding of the pathogenetic mechanisms, including genetic aberrations and epigenetic abnormalities that shape the mutational landscape of CTCL and represent one of the important pro-tumorigenic principles in CTCL initiation and progression. Still, identification of the major pathophysiological pathways including genetic and epigenetic components that mediate malignant clonal T cell expansion has not been achieved. This is of prime importance given the role of malignant T cell clones in fostering T helper 2 (Th2)-bias tumor microenvironment and fueling progressive immune dysregulation and tumor cell growth in CTCL patients, manifested by the secretion of Th2-associated cytokines and chemokines. Alterations in malignant cytokine and chemokine expression patterns orchestrate the inflammatory milieu and influence the migration dynamics of malignant clonal T cells. Here, we highlight recent insights about the molecular mechanisms of CTCL pathogenesis, emphasizing the role of cytokines, chemokines, and associated downstream signaling networks in driving immune defects, malignant transformation, and disease progression. In-depth characterization of the CTCL immunophenotype and tumoral microenvironment offers a facile opportunity to expand the therapeutic armamentarium of CTCL, an intractable malignant skin disease with poor prognosis and in dire need of curative treatment approaches.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2021.12.003" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2021.12.003</a></p>2022-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2021.12.003https://figshare.com/articles/journal_contribution/Molecular_pathogenesis_of_Cutaneous_T_cell_Lymphoma_Role_of_chemokines_cytokines_and_dysregulated_signaling_pathways/24311911CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/243119112022-11-01T00:00:00Z |
| spellingShingle | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways Kalyani Patil (2679424) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Cutaneous T cell lymphoma Chemokines Cytokines Signaling pathways Sezary syndrome Mycosis fungoides Pathophysiology |
| status_str | publishedVersion |
| title | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| title_full | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| title_fullStr | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| title_full_unstemmed | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| title_short | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| title_sort | Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Cutaneous T cell lymphoma Chemokines Cytokines Signaling pathways Sezary syndrome Mycosis fungoides Pathophysiology |