Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study
<h3>Purpose</h3><p dir="ltr">Low bicarbonate, a hallmark of metabolic acidosis is associated with various diseases. This study investigated associations between bicarbonate levels with prediabetes and subclinical inflammation among healthy young adults in Qatar.</p>...
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2023
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| _version_ | 1864513545955180544 |
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| author | Abeer A Omar (21623774) |
| author2 | Khadija J Radwani (21623777) Maryam K Al Thani (21623780) Nadin H Abouzeid (21623783) Yousef E Qabeel (21623786) Manwa Al Shamari (21623789) Tawanda Chivese (801864) Susu M Zughaier (14834656) |
| author2_role | author author author author author author author |
| author_facet | Abeer A Omar (21623774) Khadija J Radwani (21623777) Maryam K Al Thani (21623780) Nadin H Abouzeid (21623783) Yousef E Qabeel (21623786) Manwa Al Shamari (21623789) Tawanda Chivese (801864) Susu M Zughaier (14834656) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abeer A Omar (21623774) Khadija J Radwani (21623777) Maryam K Al Thani (21623780) Nadin H Abouzeid (21623783) Yousef E Qabeel (21623786) Manwa Al Shamari (21623789) Tawanda Chivese (801864) Susu M Zughaier (14834656) |
| dc.date.none.fl_str_mv | 2023-04-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/dmso.s402037 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Association_Between_Serum_Bicarbonate_Levels_and_Prediabetes_and_Subclinical_Inflammation_in_Young_Healthy_Adults_A_Cross-sectional_Study/29436005 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health bicarbonate prediabetes subclinical inflammation males females Qatar |
| dc.title.none.fl_str_mv | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Purpose</h3><p dir="ltr">Low bicarbonate, a hallmark of metabolic acidosis is associated with various diseases. This study investigated associations between bicarbonate levels with prediabetes and subclinical inflammation among healthy young adults in Qatar.</p><h3>Patients and Methods</h3><p dir="ltr">A cross-sectional study was carried out with 825 participants aged 18– 40 years, devoid of any known comorbidities, using data from the Qatar Biobank. For each participant, blood samples were taken for measurements of bicarbonate, prediabetes, and subclinical inflammation biomarkers. Prediabetes was defined using HbA1c between 5.7 and 6.4% and subclinical inflammation was defined using monocyte to high density lipoprotein (HDL) cholesterol ratio (MHR). Associations between bicarbonate levels and the outcomes were analyzed using multivariable linear and logistic regression and then stratified by gender.</p><h3>Results</h3><p dir="ltr">A total of 825 participants with mean age 29.2 years (5.9) of which 365 (44.2%) were males. After multivariable logistic regression, each unit increase in serum bicarbonate was associated with a 17% decreased risk of prediabetes (OR: 0.83, 95%CI: 0.70– 0.99, <i>p</i>=0.034), in males but no association was observed for females. Similarly, after multivariable linear regression, a unit increase in serum bicarbonate was associated with a 0.18 unit decrease in MHR (beta − 0.18, 95%CI: − 0.29, − 0.07, <i>p</i>=0.002), again with no association observed in females.</p><h3>Conclusion</h3><p dir="ltr">In a healthy young adult population, higher serum bicarbonate levels were inversely associated with both prediabetes and subclinical inflammation in males, but not in females.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes, Metabolic Syndrome and Obesity<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dmso.s402037" target="_blank">https://dx.doi.org/10.2147/dmso.s402037</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_50e6b1fb1924097c2a846ebbae48df66 |
| identifier_str_mv | 10.2147/dmso.s402037 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29436005 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional StudyAbeer A Omar (21623774)Khadija J Radwani (21623777)Maryam K Al Thani (21623780)Nadin H Abouzeid (21623783)Yousef E Qabeel (21623786)Manwa Al Shamari (21623789)Tawanda Chivese (801864)Susu M Zughaier (14834656)Biomedical and clinical sciencesMedical biochemistry and metabolomicsHealth sciencesEpidemiologyPublic healthbicarbonateprediabetessubclinical inflammationmalesfemalesQatar<h3>Purpose</h3><p dir="ltr">Low bicarbonate, a hallmark of metabolic acidosis is associated with various diseases. This study investigated associations between bicarbonate levels with prediabetes and subclinical inflammation among healthy young adults in Qatar.</p><h3>Patients and Methods</h3><p dir="ltr">A cross-sectional study was carried out with 825 participants aged 18– 40 years, devoid of any known comorbidities, using data from the Qatar Biobank. For each participant, blood samples were taken for measurements of bicarbonate, prediabetes, and subclinical inflammation biomarkers. Prediabetes was defined using HbA1c between 5.7 and 6.4% and subclinical inflammation was defined using monocyte to high density lipoprotein (HDL) cholesterol ratio (MHR). Associations between bicarbonate levels and the outcomes were analyzed using multivariable linear and logistic regression and then stratified by gender.</p><h3>Results</h3><p dir="ltr">A total of 825 participants with mean age 29.2 years (5.9) of which 365 (44.2%) were males. After multivariable logistic regression, each unit increase in serum bicarbonate was associated with a 17% decreased risk of prediabetes (OR: 0.83, 95%CI: 0.70– 0.99, <i>p</i>=0.034), in males but no association was observed for females. Similarly, after multivariable linear regression, a unit increase in serum bicarbonate was associated with a 0.18 unit decrease in MHR (beta − 0.18, 95%CI: − 0.29, − 0.07, <i>p</i>=0.002), again with no association observed in females.</p><h3>Conclusion</h3><p dir="ltr">In a healthy young adult population, higher serum bicarbonate levels were inversely associated with both prediabetes and subclinical inflammation in males, but not in females.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes, Metabolic Syndrome and Obesity<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dmso.s402037" target="_blank">https://dx.doi.org/10.2147/dmso.s402037</a></p>2023-04-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/dmso.s402037https://figshare.com/articles/journal_contribution/Association_Between_Serum_Bicarbonate_Levels_and_Prediabetes_and_Subclinical_Inflammation_in_Young_Healthy_Adults_A_Cross-sectional_Study/29436005CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294360052023-04-04T03:00:00Z |
| spellingShingle | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study Abeer A Omar (21623774) Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health bicarbonate prediabetes subclinical inflammation males females Qatar |
| status_str | publishedVersion |
| title | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| title_full | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| title_fullStr | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| title_full_unstemmed | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| title_short | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| title_sort | Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health bicarbonate prediabetes subclinical inflammation males females Qatar |