Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications
<h3>Aims</h3><p dir="ltr">Vitamin D measurement is a composite of vitamin D<sub>2</sub> (25(OH)D<sub>2</sub>) and D<sub>3</sub> (25(OH)D<sub>3</sub>) levels, and its deficiency is associated with the development of type 2 di...
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2022
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| _version_ | 1864513512970125312 |
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| author | Lina H. M. Ahmed (9571561) |
| author2 | Alexandra E. Butler (6189536) Soha R. Dargham (3613250) Aishah Latif (9424672) Amal Robay (3158892) Omar M. Chidiac (9424678) Amin Jayyousi (3158868) Jassim Al Suwaidi (284932) Ronald G. Crystal (8813645) Stephen L. Atkin (6684368) Charbel Abi Khalil (781797) |
| author2_role | author author author author author author author author author author |
| author_facet | Lina H. M. Ahmed (9571561) Alexandra E. Butler (6189536) Soha R. Dargham (3613250) Aishah Latif (9424672) Amal Robay (3158892) Omar M. Chidiac (9424678) Amin Jayyousi (3158868) Jassim Al Suwaidi (284932) Ronald G. Crystal (8813645) Stephen L. Atkin (6684368) Charbel Abi Khalil (781797) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lina H. M. Ahmed (9571561) Alexandra E. Butler (6189536) Soha R. Dargham (3613250) Aishah Latif (9424672) Amal Robay (3158892) Omar M. Chidiac (9424678) Amin Jayyousi (3158868) Jassim Al Suwaidi (284932) Ronald G. Crystal (8813645) Stephen L. Atkin (6684368) Charbel Abi Khalil (781797) |
| dc.date.none.fl_str_mv | 2022-11-22T21:17:49Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12902-020-00549-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Association_of_vitamin_D2_and_D3_with_type_2_diabetes_complications/21598353 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Vitamin D Vitamin D metabolites Type 2 diabetics Diabetic complications Vitamin D deficiency vitamin D2 Vitamin D3 |
| dc.title.none.fl_str_mv | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aims</h3><p dir="ltr">Vitamin D measurement is a composite of vitamin D<sub>2</sub> (25(OH)D<sub>2</sub>) and D<sub>3</sub> (25(OH)D<sub>3</sub>) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D<sub>2</sub> supplements. This study was undertaken to determine if vitamin D<sub>2</sub> and D<sub>3</sub> levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D<sub>2</sub> and vitamin D<sub>3</sub> levels in subjects with T2DM.</p><h3>Methods</h3><p dir="ltr">Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D<sub>2</sub> and D<sub>3</sub> were measured by LC-MS/MS analysis.</p><h3>Results</h3><p dir="ltr">All subjects were taking vitamin D<sub>2</sub> and none were taking D<sub>3</sub> supplements. Vitamin D<sub>2</sub> levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D<sub>3</sub> levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D<sub>2</sub> nor vitamin D<sub>3</sub> were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D<sub>2</sub> and vitamin D<sub>3</sub> showed no difference.</p><h3>Conclusions</h3><p dir="ltr">In this Qatari cohort, vitamin D<sub>2</sub> was associated with hypertension and dyslipidemia, whilst vitamin D<sub>3</sub> levels were associated with diabetic retinopathy. Vitamin D<sub>2</sub> levels were higher, whilst vitamin D<sub>3</sub> were lower in diabetics and females, likely due to ingestion of vitamin D<sub>2</sub> supplements.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Endocrine Disorders<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12902-020-00549-w" target="_blank">http://dx.doi.org/10.1186/s12902-020-00549-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_511e3a52deb7fcf39eaa8b10b7ebaf88 |
| identifier_str_mv | 10.1186/s12902-020-00549-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598353 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complicationsLina H. M. Ahmed (9571561)Alexandra E. Butler (6189536)Soha R. Dargham (3613250)Aishah Latif (9424672)Amal Robay (3158892)Omar M. Chidiac (9424678)Amin Jayyousi (3158868)Jassim Al Suwaidi (284932)Ronald G. Crystal (8813645)Stephen L. Atkin (6684368)Charbel Abi Khalil (781797)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsNutrition and dieteticsVitamin DVitamin D metabolitesType 2 diabeticsDiabetic complicationsVitamin D deficiencyvitamin D2Vitamin D3<h3>Aims</h3><p dir="ltr">Vitamin D measurement is a composite of vitamin D<sub>2</sub> (25(OH)D<sub>2</sub>) and D<sub>3</sub> (25(OH)D<sub>3</sub>) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D<sub>2</sub> supplements. This study was undertaken to determine if vitamin D<sub>2</sub> and D<sub>3</sub> levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D<sub>2</sub> and vitamin D<sub>3</sub> levels in subjects with T2DM.</p><h3>Methods</h3><p dir="ltr">Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D<sub>2</sub> and D<sub>3</sub> were measured by LC-MS/MS analysis.</p><h3>Results</h3><p dir="ltr">All subjects were taking vitamin D<sub>2</sub> and none were taking D<sub>3</sub> supplements. Vitamin D<sub>2</sub> levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D<sub>3</sub> levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D<sub>2</sub> nor vitamin D<sub>3</sub> were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D<sub>2</sub> and vitamin D<sub>3</sub> showed no difference.</p><h3>Conclusions</h3><p dir="ltr">In this Qatari cohort, vitamin D<sub>2</sub> was associated with hypertension and dyslipidemia, whilst vitamin D<sub>3</sub> levels were associated with diabetic retinopathy. Vitamin D<sub>2</sub> levels were higher, whilst vitamin D<sub>3</sub> were lower in diabetics and females, likely due to ingestion of vitamin D<sub>2</sub> supplements.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Endocrine Disorders<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12902-020-00549-w" target="_blank">http://dx.doi.org/10.1186/s12902-020-00549-w</a></p>2022-11-22T21:17:49ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12902-020-00549-whttps://figshare.com/articles/journal_contribution/Association_of_vitamin_D2_and_D3_with_type_2_diabetes_complications/21598353CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983532022-11-22T21:17:49Z |
| spellingShingle | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications Lina H. M. Ahmed (9571561) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Vitamin D Vitamin D metabolites Type 2 diabetics Diabetic complications Vitamin D deficiency vitamin D2 Vitamin D3 |
| status_str | publishedVersion |
| title | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| title_full | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| title_fullStr | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| title_full_unstemmed | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| title_short | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| title_sort | Association of vitamin D<sub>2</sub> and D<sub>3</sub> with type 2 diabetes complications |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Vitamin D Vitamin D metabolites Type 2 diabetics Diabetic complications Vitamin D deficiency vitamin D2 Vitamin D3 |