The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease
<p dir="ltr">Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and CKD. The aim of the study was to examine the influence of prebiotic – gum acacia (GA) on the intestinal microbiota in ra...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| الموضوعات: | |
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| _version_ | 1864513557850226688 |
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| author | Arun Prasath Lakshmanan (6807152) |
| author2 | Mohammed Al Za’abi (2214412) Badreldin H Ali (17075200) Annalisa Terranegra (3486953) |
| author2_role | author author author |
| author_facet | Arun Prasath Lakshmanan (6807152) Mohammed Al Za’abi (2214412) Badreldin H Ali (17075200) Annalisa Terranegra (3486953) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arun Prasath Lakshmanan (6807152) Mohammed Al Za’abi (2214412) Badreldin H Ali (17075200) Annalisa Terranegra (3486953) |
| dc.date.none.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2020.110992 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_influence_of_the_prebiotic_gum_acacia_on_the_intestinal_microbiome_composition_in_rats_with_experimental_chronic_kidney_disease/24225598 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Gum acacia Intestinal microbiome Butyrate |
| dc.title.none.fl_str_mv | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and CKD. The aim of the study was to examine the influence of prebiotic – gum acacia (GA) on the intestinal microbiota in rats with adenine-induced CKD. Animals were randomly distributed into four equal groups (n = 6): control, adenine, GA and adenine + GA groups. CKD was induced by adenine (0.75% w/w) given in the diet daily for four weeks, and GA was administered in drinking water at a concentration of 15% w/v. The 16s rRNA analysis was performed on Illumina Miseq targeting V3-V4 region to characterize microbial composition. The abundance of Actinobacteria, Proteobacteria, Tenericutes and Verrucomicrobia bacteria was increased in adenine-induced CKD, and GA treatment successfully reversed those levels. Interestingly, alpha and beta diversity index were both reduced with GA treatment in rats with CKD. Short chain fatty acids (SCFAs) measurement and PICRUSt analysis have shown that GA treatment completely restored the depleted butyrate level and various perturbated functional pathways, respectively, in CKD rats. Taking together, our results suggest that GA supplementation has a beneficial role in treating CKD, through an increased production of butyrate, as well as its anti-inflammatory, antioxidant capacity and anti-nitrosative properties.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2020.110992" target="_blank">https://dx.doi.org/10.1016/j.biopha.2020.110992</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5240db331e19e19486a8ef81b9be0b5e |
| identifier_str_mv | 10.1016/j.biopha.2020.110992 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24225598 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney diseaseArun Prasath Lakshmanan (6807152)Mohammed Al Za’abi (2214412)Badreldin H Ali (17075200)Annalisa Terranegra (3486953)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesChronic kidney diseaseGum acaciaIntestinal microbiomeButyrate<p dir="ltr">Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and CKD. The aim of the study was to examine the influence of prebiotic – gum acacia (GA) on the intestinal microbiota in rats with adenine-induced CKD. Animals were randomly distributed into four equal groups (n = 6): control, adenine, GA and adenine + GA groups. CKD was induced by adenine (0.75% w/w) given in the diet daily for four weeks, and GA was administered in drinking water at a concentration of 15% w/v. The 16s rRNA analysis was performed on Illumina Miseq targeting V3-V4 region to characterize microbial composition. The abundance of Actinobacteria, Proteobacteria, Tenericutes and Verrucomicrobia bacteria was increased in adenine-induced CKD, and GA treatment successfully reversed those levels. Interestingly, alpha and beta diversity index were both reduced with GA treatment in rats with CKD. Short chain fatty acids (SCFAs) measurement and PICRUSt analysis have shown that GA treatment completely restored the depleted butyrate level and various perturbated functional pathways, respectively, in CKD rats. Taking together, our results suggest that GA supplementation has a beneficial role in treating CKD, through an increased production of butyrate, as well as its anti-inflammatory, antioxidant capacity and anti-nitrosative properties.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2020.110992" target="_blank">https://dx.doi.org/10.1016/j.biopha.2020.110992</a></p>2021-01-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2020.110992https://figshare.com/articles/journal_contribution/The_influence_of_the_prebiotic_gum_acacia_on_the_intestinal_microbiome_composition_in_rats_with_experimental_chronic_kidney_disease/24225598CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242255982021-01-01T00:00:00Z |
| spellingShingle | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease Arun Prasath Lakshmanan (6807152) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Gum acacia Intestinal microbiome Butyrate |
| status_str | publishedVersion |
| title | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| title_full | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| title_fullStr | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| title_full_unstemmed | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| title_short | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| title_sort | The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Chronic kidney disease Gum acacia Intestinal microbiome Butyrate |