Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment
<p dir="ltr">This review delves into the intricacies of Photodynamic Therapy (PDT), focusing on mechanisms such as the accumulation of selective photosensitizers and the generation of Reactive Oxygen Species (ROS). Research is investigating the use of zirconium oxide nanoparticles (Z...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513521713152000 |
|---|---|
| author | Alshayma N. Al-Thani (17976380) |
| author2 | Asma Ghafoor Jan (19736878) Zainab Hajialthakar (22254328) Nada Aakel (18877111) Mohamed Abbas (834428) |
| author2_role | author author author author |
| author_facet | Alshayma N. Al-Thani (17976380) Asma Ghafoor Jan (19736878) Zainab Hajialthakar (22254328) Nada Aakel (18877111) Mohamed Abbas (834428) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alshayma N. Al-Thani (17976380) Asma Ghafoor Jan (19736878) Zainab Hajialthakar (22254328) Nada Aakel (18877111) Mohamed Abbas (834428) |
| dc.date.none.fl_str_mv | 2025-12-25T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.nano.2025.102876 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Zirconium_oxide_nanoparticles_in_advancing_photodynamic_therapy_for_cancer_treatment/32033835 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Photodynamic therapy Zirconium oxide nanoparticles Reactive oxygen species Cancer cell |
| dc.title.none.fl_str_mv | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">This review delves into the intricacies of Photodynamic Therapy (PDT), focusing on mechanisms such as the accumulation of selective photosensitizers and the generation of Reactive Oxygen Species (ROS). Research is investigating the use of zirconium oxide nanoparticles (ZrO<sub>2</sub> NPs) and their combination with upconversion nanoparticles. The functionalization of ZrO<sub>2</sub> NPs is stressed for targeted drug administration and enhanced therapeutic effects. Addressing PDT challenges, ZrO<sub>2</sub> NPs exhibit potential to enhance treatment accuracy, minimize side effects, and improve overall success. Supported by preclinical and clinical research, zirconium-based PDT emerges as a transformative cancer therapy technique. Integrating ZrO<sub>2</sub> NPs into PDT represents a groundbreaking approach, allowing selective cancer cell targeting and promising improved treatment outcomes and synergies with other modalities. With demonstrated safety and efficacy, ZrO<sub>2</sub> PDT constitutes a vital component in advancing cancer patient outcomes globally.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Nanomedicine: Nanotechnology, Biology and Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.nano.2025.102876" target="_blank">https://dx.doi.org/10.1016/j.nano.2025.102876</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5309e959a0d7baa42ec5e15eb9cfda9b |
| identifier_str_mv | 10.1016/j.nano.2025.102876 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/32033835 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatmentAlshayma N. Al-Thani (17976380)Asma Ghafoor Jan (19736878)Zainab Hajialthakar (22254328)Nada Aakel (18877111)Mohamed Abbas (834428)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringMaterials engineeringNanotechnologyPhotodynamic therapyZirconium oxide nanoparticlesReactive oxygen speciesCancer cell<p dir="ltr">This review delves into the intricacies of Photodynamic Therapy (PDT), focusing on mechanisms such as the accumulation of selective photosensitizers and the generation of Reactive Oxygen Species (ROS). Research is investigating the use of zirconium oxide nanoparticles (ZrO<sub>2</sub> NPs) and their combination with upconversion nanoparticles. The functionalization of ZrO<sub>2</sub> NPs is stressed for targeted drug administration and enhanced therapeutic effects. Addressing PDT challenges, ZrO<sub>2</sub> NPs exhibit potential to enhance treatment accuracy, minimize side effects, and improve overall success. Supported by preclinical and clinical research, zirconium-based PDT emerges as a transformative cancer therapy technique. Integrating ZrO<sub>2</sub> NPs into PDT represents a groundbreaking approach, allowing selective cancer cell targeting and promising improved treatment outcomes and synergies with other modalities. With demonstrated safety and efficacy, ZrO<sub>2</sub> PDT constitutes a vital component in advancing cancer patient outcomes globally.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Nanomedicine: Nanotechnology, Biology and Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.nano.2025.102876" target="_blank">https://dx.doi.org/10.1016/j.nano.2025.102876</a></p>2025-12-25T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.nano.2025.102876https://figshare.com/articles/journal_contribution/Zirconium_oxide_nanoparticles_in_advancing_photodynamic_therapy_for_cancer_treatment/32033835CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/320338352025-12-25T18:00:00Z |
| spellingShingle | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment Alshayma N. Al-Thani (17976380) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Photodynamic therapy Zirconium oxide nanoparticles Reactive oxygen species Cancer cell |
| status_str | publishedVersion |
| title | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| title_full | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| title_fullStr | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| title_full_unstemmed | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| title_short | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| title_sort | Zirconium oxide nanoparticles in advancing photodynamic therapy for cancer treatment |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Materials engineering Nanotechnology Photodynamic therapy Zirconium oxide nanoparticles Reactive oxygen species Cancer cell |