Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine
<p dir="ltr">Mesoporous silica (mSiO<sub>2</sub>) micro/nanomotors (MNMs) are a groundbreaking innovation in nanotechnology and versatile tools in biomedical science. Combining active propulsion and advanced functionality, they navigate complex biological environments, ov...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| _version_ | 1864513550801698816 |
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| author | Farah M. ElMakaty (20884235) |
| author2 | Ma.Ellyza Andrea J. Ona (20884238) Xiaomin Li (207257) Ahmed A. Elzatahry (1551847) Mohamed F. Mady (2873918) |
| author2_role | author author author author |
| author_facet | Farah M. ElMakaty (20884235) Ma.Ellyza Andrea J. Ona (20884238) Xiaomin Li (207257) Ahmed A. Elzatahry (1551847) Mohamed F. Mady (2873918) |
| author_role | author |
| dc.creator.none.fl_str_mv | Farah M. ElMakaty (20884235) Ma.Ellyza Andrea J. Ona (20884238) Xiaomin Li (207257) Ahmed A. Elzatahry (1551847) Mohamed F. Mady (2873918) |
| dc.date.none.fl_str_mv | 2025-03-13T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.apmt.2025.102673 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Mesoporous_silica_micro_nanomotors_A_new_horizon_in_biomedical_applications_and_precision_medicine/28602932 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Engineering Biomedical engineering Nanotechnology Nanomotors Mesoporous silica Medicine Structure Asymmetric |
| dc.title.none.fl_str_mv | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Mesoporous silica (mSiO<sub>2</sub>) micro/nanomotors (MNMs) are a groundbreaking innovation in nanotechnology and versatile tools in biomedical science. Combining active propulsion and advanced functionality, they navigate complex biological environments, overcome the limitations of traditional therapies, and expand the horizons of precision medicine. Central to their versatility is the mSiO<sub>2</sub> framework, which offers a high surface area, tunable porosity, and inherent biocompatibility. These properties enable efficient drug loading, controlled release, and functionalization for advanced therapeutic and diagnostic applications. MNMs are designed with diverse structures, including Janus, core-shell, yolk-shell, hollow, and biomimetic architectures, each meticulously tailored to meet the demands of specific biomedical applications. Utilizing active propulsion mechanisms—chemical, light-driven, magnetic, and hybrid—MNMs achieve precise targeting and enhanced efficacy in cancer therapy, cardiovascular treatments, and infection management. This review explores the synthesis methods, structural innovations, and biomedical applications of MNMs, emphasizing their transformative role in overcoming the limitations of passive systems. By leveraging the adaptability of mSiO<sub>2</sub>, MNMs effectively address critical challenges such as fuel toxicity, hypoxia, dense extracellular matrices, and biofilm resistance. Furthermore, the review highlights future prospects, including the integration of multimodal therapies, optimization of biocompatibility, and expanding clinical applicability, establishing mSiO<sub>2</sub>-based MNMs as key tools in precision medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Applied Materials Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.apmt.2025.102673" target="_blank">https://dx.doi.org/10.1016/j.apmt.2025.102673</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_53de2145c99540b96340241c34f7a82e |
| identifier_str_mv | 10.1016/j.apmt.2025.102673 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28602932 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicineFarah M. ElMakaty (20884235)Ma.Ellyza Andrea J. Ona (20884238)Xiaomin Li (207257)Ahmed A. Elzatahry (1551847)Mohamed F. Mady (2873918)Biomedical and clinical sciencesClinical sciencesEngineeringBiomedical engineeringNanotechnologyNanomotorsMesoporous silicaMedicineStructureAsymmetric<p dir="ltr">Mesoporous silica (mSiO<sub>2</sub>) micro/nanomotors (MNMs) are a groundbreaking innovation in nanotechnology and versatile tools in biomedical science. Combining active propulsion and advanced functionality, they navigate complex biological environments, overcome the limitations of traditional therapies, and expand the horizons of precision medicine. Central to their versatility is the mSiO<sub>2</sub> framework, which offers a high surface area, tunable porosity, and inherent biocompatibility. These properties enable efficient drug loading, controlled release, and functionalization for advanced therapeutic and diagnostic applications. MNMs are designed with diverse structures, including Janus, core-shell, yolk-shell, hollow, and biomimetic architectures, each meticulously tailored to meet the demands of specific biomedical applications. Utilizing active propulsion mechanisms—chemical, light-driven, magnetic, and hybrid—MNMs achieve precise targeting and enhanced efficacy in cancer therapy, cardiovascular treatments, and infection management. This review explores the synthesis methods, structural innovations, and biomedical applications of MNMs, emphasizing their transformative role in overcoming the limitations of passive systems. By leveraging the adaptability of mSiO<sub>2</sub>, MNMs effectively address critical challenges such as fuel toxicity, hypoxia, dense extracellular matrices, and biofilm resistance. Furthermore, the review highlights future prospects, including the integration of multimodal therapies, optimization of biocompatibility, and expanding clinical applicability, establishing mSiO<sub>2</sub>-based MNMs as key tools in precision medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Applied Materials Today<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.apmt.2025.102673" target="_blank">https://dx.doi.org/10.1016/j.apmt.2025.102673</a></p>2025-03-13T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.apmt.2025.102673https://figshare.com/articles/journal_contribution/Mesoporous_silica_micro_nanomotors_A_new_horizon_in_biomedical_applications_and_precision_medicine/28602932CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/286029322025-03-13T12:00:00Z |
| spellingShingle | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine Farah M. ElMakaty (20884235) Biomedical and clinical sciences Clinical sciences Engineering Biomedical engineering Nanotechnology Nanomotors Mesoporous silica Medicine Structure Asymmetric |
| status_str | publishedVersion |
| title | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| title_full | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| title_fullStr | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| title_full_unstemmed | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| title_short | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| title_sort | Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine |
| topic | Biomedical and clinical sciences Clinical sciences Engineering Biomedical engineering Nanotechnology Nanomotors Mesoporous silica Medicine Structure Asymmetric |