The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma
<h3>Background</h3><p dir="ltr">Gut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most c...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| _version_ | 1864513532728442880 |
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| author | Sarah A. Elkourashy (21632903) |
| author2 | Rasha Abu-El-Ruz (10650680) Medhat Z. Askar (22564124) Ahmad Hamdan (332542) Susu M. Zughaier (14151987) |
| author2_role | author author author author |
| author_facet | Sarah A. Elkourashy (21632903) Rasha Abu-El-Ruz (10650680) Medhat Z. Askar (22564124) Ahmad Hamdan (332542) Susu M. Zughaier (14151987) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sarah A. Elkourashy (21632903) Rasha Abu-El-Ruz (10650680) Medhat Z. Askar (22564124) Ahmad Hamdan (332542) Susu M. Zughaier (14151987) |
| dc.date.none.fl_str_mv | 2025-10-30T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.blre.2025.101341 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_microbiome-lymphoma_Axis_A_systematic_review_and_Meta-analysis_of_gut_Dysbiosis_pattern_in_diffuse_large_B-cell_lymphoma/30540041 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Gut microbiota Diffuse large B-cell lymphoma Non-Hodgkin lymphoma Dysbiosis Lymphomagenesis Immune modulation Microbiome-targeted therapy |
| dc.title.none.fl_str_mv | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Gut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most common and aggressive subtype of non-Hodgkin lymphoma (NHL). However, a comprehensive synthesis of the microbial alterations associated with DLBCL remains poorly defined. </p><h3>Methods</h3><p dir="ltr">We systematically reviewed and meta-analyzed thirteen studies (<i>n</i> = 4087 cases) to assess gut microbiota alterations in DLBCL. Both observational and Mendelian randomization designs were included. Pooled odds ratios (OR) were calculated for mendelian randomization studies using random-effects models, and microbial shifts were analyzed at the species level to contextualize biological relevance. Observational studies were used for qualitative assessment.</p><h3>Results</h3><p dir="ltr">Meta analysis was done for the mendelian randomization studies (<i>n</i> = 3737 cases). The overall pooled OR was 0.96 (95 % CI: 0.93–1.00), suggested a slight shift towards depletion, with considerable heterogeneity (I<sup>2</sup> = 78.7 %). Species-level analysis revealed significant enrichment of pro-inflammatory or potentially oncogenic taxa in DLBCL, including Bilophila (OR = 1.78), Desulfovibrionaceae (OR = 1.58), and Coprobacter (OR = 1.37). Conversely, beneficial commensals with anti-inflammatory and metabolic regulatory roles such as <i>Eubacterium coprostanoligenes</i> group (OR = 0.19), Alistipes (OR = 0.57), <i>Ruminococcaceae</i> UCG011 (OR = 0.75) were significantly depleted. </p><h3>Conclusions</h3><p dir="ltr">This first comprehensive synthesis demonstrates a reproducible species-level microbial signature in DLBCL, characterized by depletion of protective commensals and enrichment of pro-tumorigenic taxa. Mechanistically, these shifts may promote lymphomagenesis via inflammatory, metabolic, and immune-modulatory pathways. Our findings highlight the gut microbiota as a latent biomarker source and therapeutic target, supporting microbiota-modulating strategies in precision lymphoma care.</p><h2>Other Information</h2><p dir="ltr">Published in: Blood Reviews<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.blre.2025.101341" target="_blank">https://dx.doi.org/10.1016/j.blre.2025.101341</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5401e47357b626dfda9684e04f515475 |
| identifier_str_mv | 10.1016/j.blre.2025.101341 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30540041 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphomaSarah A. Elkourashy (21632903)Rasha Abu-El-Ruz (10650680)Medhat Z. Askar (22564124)Ahmad Hamdan (332542)Susu M. Zughaier (14151987)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisGut microbiotaDiffuse large B-cell lymphomaNon-Hodgkin lymphomaDysbiosisLymphomagenesisImmune modulationMicrobiome-targeted therapy<h3>Background</h3><p dir="ltr">Gut microbiota has emerged as a critical mediator of immune homeostasis and cancer biology. Increasing evidence suggests that gut dysbiosis may play a significant role in the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most common and aggressive subtype of non-Hodgkin lymphoma (NHL). However, a comprehensive synthesis of the microbial alterations associated with DLBCL remains poorly defined. </p><h3>Methods</h3><p dir="ltr">We systematically reviewed and meta-analyzed thirteen studies (<i>n</i> = 4087 cases) to assess gut microbiota alterations in DLBCL. Both observational and Mendelian randomization designs were included. Pooled odds ratios (OR) were calculated for mendelian randomization studies using random-effects models, and microbial shifts were analyzed at the species level to contextualize biological relevance. Observational studies were used for qualitative assessment.</p><h3>Results</h3><p dir="ltr">Meta analysis was done for the mendelian randomization studies (<i>n</i> = 3737 cases). The overall pooled OR was 0.96 (95 % CI: 0.93–1.00), suggested a slight shift towards depletion, with considerable heterogeneity (I<sup>2</sup> = 78.7 %). Species-level analysis revealed significant enrichment of pro-inflammatory or potentially oncogenic taxa in DLBCL, including Bilophila (OR = 1.78), Desulfovibrionaceae (OR = 1.58), and Coprobacter (OR = 1.37). Conversely, beneficial commensals with anti-inflammatory and metabolic regulatory roles such as <i>Eubacterium coprostanoligenes</i> group (OR = 0.19), Alistipes (OR = 0.57), <i>Ruminococcaceae</i> UCG011 (OR = 0.75) were significantly depleted. </p><h3>Conclusions</h3><p dir="ltr">This first comprehensive synthesis demonstrates a reproducible species-level microbial signature in DLBCL, characterized by depletion of protective commensals and enrichment of pro-tumorigenic taxa. Mechanistically, these shifts may promote lymphomagenesis via inflammatory, metabolic, and immune-modulatory pathways. Our findings highlight the gut microbiota as a latent biomarker source and therapeutic target, supporting microbiota-modulating strategies in precision lymphoma care.</p><h2>Other Information</h2><p dir="ltr">Published in: Blood Reviews<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.blre.2025.101341" target="_blank">https://dx.doi.org/10.1016/j.blre.2025.101341</a></p>2025-10-30T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.blre.2025.101341https://figshare.com/articles/journal_contribution/The_microbiome-lymphoma_Axis_A_systematic_review_and_Meta-analysis_of_gut_Dysbiosis_pattern_in_diffuse_large_B-cell_lymphoma/30540041CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/305400412025-10-30T09:00:00Z |
| spellingShingle | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma Sarah A. Elkourashy (21632903) Biomedical and clinical sciences Immunology Oncology and carcinogenesis Gut microbiota Diffuse large B-cell lymphoma Non-Hodgkin lymphoma Dysbiosis Lymphomagenesis Immune modulation Microbiome-targeted therapy |
| status_str | publishedVersion |
| title | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| title_full | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| title_fullStr | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| title_full_unstemmed | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| title_short | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| title_sort | The microbiome-lymphoma Axis: A systematic review and Meta-analysis of gut Dysbiosis pattern in diffuse large B-cell lymphoma |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Gut microbiota Diffuse large B-cell lymphoma Non-Hodgkin lymphoma Dysbiosis Lymphomagenesis Immune modulation Microbiome-targeted therapy |