Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice
<p dir="ltr">Chronic use of synthetic <u>cannabinoids</u> (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of...
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2024
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| _version_ | 1864513542118440960 |
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| author | Ayman Alzu'bi (18192898) |
| author2 | Ejlal Abu-El-Rub (5168183) Fatimah Almahasneh (21633368) Lena Tahat (18192907) Rabaa Y. Athamneh (21842702) Ramada Khasawneh (21633371) Hiba Alzoubi (18001609) Doaa S. Ghorab (18192913) Rawan Almazari (21842705) Mazhar Salim Al Zoubi (17863880) Raed M. Al-Zoubi (2037490) |
| author2_role | author author author author author author author author author author |
| author_facet | Ayman Alzu'bi (18192898) Ejlal Abu-El-Rub (5168183) Fatimah Almahasneh (21633368) Lena Tahat (18192907) Rabaa Y. Athamneh (21842702) Ramada Khasawneh (21633371) Hiba Alzoubi (18001609) Doaa S. Ghorab (18192913) Rawan Almazari (21842705) Mazhar Salim Al Zoubi (17863880) Raed M. Al-Zoubi (2037490) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ayman Alzu'bi (18192898) Ejlal Abu-El-Rub (5168183) Fatimah Almahasneh (21633368) Lena Tahat (18192907) Rabaa Y. Athamneh (21842702) Ramada Khasawneh (21633371) Hiba Alzoubi (18001609) Doaa S. Ghorab (18192913) Rawan Almazari (21842705) Mazhar Salim Al Zoubi (17863880) Raed M. Al-Zoubi (2037490) |
| dc.date.none.fl_str_mv | 2024-06-08T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.neuro.2024.05.009 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Delineating_the_molecular_mechanisms_of_hippocampal_neurotoxicity_induced_by_chronic_administration_of_synthetic_cannabinoid_AB-FUBINACA_in_mice/29716265 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |
| dc.title.none.fl_str_mv | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Chronic use of synthetic <u>cannabinoids</u> (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the <u>hippocampus</u> in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. These findings were found to be correlated with increased level of <u>oxidative stress, neuroinflammation,</u> and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating <u>synaptic plasticity</u> integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. These findings shed light on the long-term neurotoxic effects of SCs on hippocampus and the underlying mechanisms of these effects. This study provided new targets for possible medical interventions to improve the treatment guidelines for SCs addiction.</p><h2>Other Information</h2><p dir="ltr">Published in: NeuroToxicology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.neuro.2024.05.009" target="_blank">https://dx.doi.org/10.1016/j.neuro.2024.05.009</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_540aa57adb4ac9aa7c8137520cb3ce5e |
| identifier_str_mv | 10.1016/j.neuro.2024.05.009 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29716265 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in miceAyman Alzu'bi (18192898)Ejlal Abu-El-Rub (5168183)Fatimah Almahasneh (21633368)Lena Tahat (18192907)Rabaa Y. Athamneh (21842702)Ramada Khasawneh (21633371)Hiba Alzoubi (18001609)Doaa S. Ghorab (18192913)Rawan Almazari (21842705)Mazhar Salim Al Zoubi (17863880)Raed M. Al-Zoubi (2037490)Biomedical and clinical sciencesNeurosciencesPharmacology and pharmaceutical sciencesSynthetic cannabinoidsAB-FUBINACANeurotoxicityRecognition memoryPsychosisOxidative stress<p dir="ltr">Chronic use of synthetic <u>cannabinoids</u> (SCs) has been associated with cognitive and behavioural deficits and an increased risk of neuropsychiatric disorders. The underlying molecular and cellular mechanisms of the neurotoxic effects of long-term use of SCs have not been well investigated in the literature. Herein, we evaluated the in vivo effects of chronic administration of AB-FUBINACA on the <u>hippocampus</u> in mice. Our results revealed that the administration of AB-FUBINACA induced a significant impairment in recognition memory associated with histopathological changes in the hippocampus. These findings were found to be correlated with increased level of <u>oxidative stress, neuroinflammation,</u> and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating <u>synaptic plasticity</u> integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. These findings shed light on the long-term neurotoxic effects of SCs on hippocampus and the underlying mechanisms of these effects. This study provided new targets for possible medical interventions to improve the treatment guidelines for SCs addiction.</p><h2>Other Information</h2><p dir="ltr">Published in: NeuroToxicology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.neuro.2024.05.009" target="_blank">https://dx.doi.org/10.1016/j.neuro.2024.05.009</a></p>2024-06-08T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.neuro.2024.05.009https://figshare.com/articles/journal_contribution/Delineating_the_molecular_mechanisms_of_hippocampal_neurotoxicity_induced_by_chronic_administration_of_synthetic_cannabinoid_AB-FUBINACA_in_mice/29716265CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297162652024-06-08T06:00:00Z |
| spellingShingle | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice Ayman Alzu'bi (18192898) Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |
| status_str | publishedVersion |
| title | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_full | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_fullStr | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_full_unstemmed | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_short | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| title_sort | Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice |
| topic | Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Neurotoxicity Recognition memory Psychosis Oxidative stress |