Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

<div><p>α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based ass...

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Main Author: Keita Kakuda (9668898) (author)
Other Authors: Kensuke Ikenaka (280400) (author), Katsuya Araki (2620255) (author), Masatomo So (1532092) (author), César Aguirre (18615127) (author), Yuta Kajiyama (11843735) (author), Kuni Konaka (18615130) (author), Kentaro Noi (5181488) (author), Kousuke Baba (818824) (author), Hiroshi Tsuda (209228) (author), Seiichi Nagano (9668904) (author), Takuma Ohmichi (718120) (author), Yoshitaka Nagai (115940) (author), Takahiko Tokuda (105837) (author), Omar M. A. El-Agnaf (8809331) (author), Hirotsugu Ogi (5181491) (author), Yuji Goto (573359) (author), Hideki Mochizuki (204792) (author)
Published: 2019
Subjects:
Biomedical and clinical sciences
Neurosciences
Seeding activity
Cerebrospinal fluid (CSF)
Diagnosis
High-throughput assay
Ultrasonication-induced amyloid fibrillation assay
Clinical indicators
Oligomers
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