Editorial: Itch treatments
<p dir="ltr">Similar to pain, pruritus (itch) is a very common somato-sensory sensation that almost everyone experiences in their lifetime. Once dysregulated, pruritus can become chronic and debilitating, significantly affecting a patient's and their family's quality of lif...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2024
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إضافة وسم
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| _version_ | 1864513509327372288 |
|---|---|
| author | Martin Steinhoff (5340194) |
| author2 | Shawn Kwatra (10486030) Laurent Misery (363611) |
| author2_role | author author |
| author_facet | Martin Steinhoff (5340194) Shawn Kwatra (10486030) Laurent Misery (363611) |
| author_role | author |
| dc.creator.none.fl_str_mv | Martin Steinhoff (5340194) Shawn Kwatra (10486030) Laurent Misery (363611) |
| dc.date.none.fl_str_mv | 2024-02-16T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmed.2024.1373702 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Editorial_Itch_treatments/26508265 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Pruritus Itch Somato-Sensory Sensation Chronic Itch Molecular Mechanisms Histamine-Dependent Itch Histamine-Independent Itch Neuropathic Pruritus |
| dc.title.none.fl_str_mv | Editorial: Itch treatments |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Similar to pain, pruritus (itch) is a very common somato-sensory sensation that almost everyone experiences in their lifetime. Once dysregulated, pruritus can become chronic and debilitating, significantly affecting a patient's and their family's quality of life (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B1" target="_blank">1</a>). Molecular biology and translational research have helped to better identify and understand the molecular mechanisms of the various pathways of histamine-dependent and -independent itch and supported the development of new treatment options for the different subtypes of pruritic diseases, whether inflammatory or non-inflammatory, neurologic or neuropathic, for example (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B2" target="_blank">2</a>–<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B6" target="_blank">6</a>). Furthermore, to identify the cellular mechanisms that differentiate and specify the different itch pathways in the various pruritic diseases is critical (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B7" target="_blank">7</a>). The treatment options for CP span a number of topical and systemic medications as well as phototherapy, depending on the underlying disease, age, and comorbidities (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B8" target="_blank">8</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B9" target="_blank">9</a>). Even in pruritus of unknown origin, the anti-IL-4 receptor-a antibody dupilumab has been shown to be effective, at least in a case report, suggesting that cytokines and microinflammation play a role in presumptive “non-inflammatory” conditions to a larger extent than anticipated (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B1" target="_blank">1</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B6" target="_blank">6</a>). However, neuro-modulatory agents are still necessary in various pruritic diseases, especially to treat neuropathic pruritus (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B2" target="_blank">2</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B5" target="_blank">5</a>) or prurigo (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B7" target="_blank">7</a>). Here, extensive translational and clinical studies are necessary to stratify the best treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmed.2024.1373702" target="_blank">https://dx.doi.org/10.3389/fmed.2024.1373702</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_549cd0e09c2cb3c49641db4899ed8713 |
| identifier_str_mv | 10.3389/fmed.2024.1373702 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26508265 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Editorial: Itch treatmentsMartin Steinhoff (5340194)Shawn Kwatra (10486030)Laurent Misery (363611)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesClinical sciencesPruritus ItchSomato-Sensory SensationChronic ItchMolecular MechanismsHistamine-Dependent ItchHistamine-Independent ItchNeuropathic Pruritus<p dir="ltr">Similar to pain, pruritus (itch) is a very common somato-sensory sensation that almost everyone experiences in their lifetime. Once dysregulated, pruritus can become chronic and debilitating, significantly affecting a patient's and their family's quality of life (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B1" target="_blank">1</a>). Molecular biology and translational research have helped to better identify and understand the molecular mechanisms of the various pathways of histamine-dependent and -independent itch and supported the development of new treatment options for the different subtypes of pruritic diseases, whether inflammatory or non-inflammatory, neurologic or neuropathic, for example (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B2" target="_blank">2</a>–<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B6" target="_blank">6</a>). Furthermore, to identify the cellular mechanisms that differentiate and specify the different itch pathways in the various pruritic diseases is critical (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B7" target="_blank">7</a>). The treatment options for CP span a number of topical and systemic medications as well as phototherapy, depending on the underlying disease, age, and comorbidities (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B8" target="_blank">8</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B9" target="_blank">9</a>). Even in pruritus of unknown origin, the anti-IL-4 receptor-a antibody dupilumab has been shown to be effective, at least in a case report, suggesting that cytokines and microinflammation play a role in presumptive “non-inflammatory” conditions to a larger extent than anticipated (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B1" target="_blank">1</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B6" target="_blank">6</a>). However, neuro-modulatory agents are still necessary in various pruritic diseases, especially to treat neuropathic pruritus (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B2" target="_blank">2</a>, <a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B5" target="_blank">5</a>) or prurigo (<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1373702/full#B7" target="_blank">7</a>). Here, extensive translational and clinical studies are necessary to stratify the best treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmed.2024.1373702" target="_blank">https://dx.doi.org/10.3389/fmed.2024.1373702</a></p>2024-02-16T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmed.2024.1373702https://figshare.com/articles/journal_contribution/Editorial_Itch_treatments/26508265CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/265082652024-02-16T18:00:00Z |
| spellingShingle | Editorial: Itch treatments Martin Steinhoff (5340194) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Pruritus Itch Somato-Sensory Sensation Chronic Itch Molecular Mechanisms Histamine-Dependent Itch Histamine-Independent Itch Neuropathic Pruritus |
| status_str | publishedVersion |
| title | Editorial: Itch treatments |
| title_full | Editorial: Itch treatments |
| title_fullStr | Editorial: Itch treatments |
| title_full_unstemmed | Editorial: Itch treatments |
| title_short | Editorial: Itch treatments |
| title_sort | Editorial: Itch treatments |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Pruritus Itch Somato-Sensory Sensation Chronic Itch Molecular Mechanisms Histamine-Dependent Itch Histamine-Independent Itch Neuropathic Pruritus |