Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility
<p dir="ltr">The development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. The widely used nanofiber fabrication methods like electrospinning are time consuming and the obtained nanof...
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2023
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| _version_ | 1864513540520411136 |
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| author | Robin Augustine (3976964) |
| author2 | Sumama Nuthana Kalva (17302906) Yogesh B. Dalvi (5938502) Ruby Varghese (5938514) Maneesh Chandran (17346856) Anwarul Hasan (1332066) |
| author2_role | author author author author author |
| author_facet | Robin Augustine (3976964) Sumama Nuthana Kalva (17302906) Yogesh B. Dalvi (5938502) Ruby Varghese (5938514) Maneesh Chandran (17346856) Anwarul Hasan (1332066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Robin Augustine (3976964) Sumama Nuthana Kalva (17302906) Yogesh B. Dalvi (5938502) Ruby Varghese (5938514) Maneesh Chandran (17346856) Anwarul Hasan (1332066) |
| dc.date.none.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.colsurfb.2022.112958 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Air-jet_spun_tissue_engineering_scaffolds_incorporated_with_diamond_nanosheets_with_improved_mechanical_strength_and_biocompatibility/24516424 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Biomedical engineering Chemical engineering Materials engineering Mechanical engineering Nanotechnology Tissue engineering Polycaprolactone Nanodiamond Air-jet spinning |
| dc.title.none.fl_str_mv | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. The widely used nanofiber fabrication methods like electrospinning are time consuming and the obtained nanofibrous scaffolds are generally consist of compactly packed fibers, which affect proper cell penetration. On the other hand, air-jet spinning is an upcoming, less explored alternative approach for generating loosely arranged nanofibrous scaffolds within short time. However, air-jet spun scaffolds show inferior mechanical properties due to loosely organized fibers. Herein, we report the fabrication and detailed characterization of polycaprolactone (PCL) tissue engineering scaffolds loaded with diamond nanosheets (DNS) by air-jet spinning. Our results showed that the inclusion of DNS could improve the mechanical strength of the scaffolds. In vitro biocompatibility, and in vivo implantation studies demonstrated that PCL-DNS scaffolds are highly biocompatible and are suitable for tissue engineering applications. Our studies showed that mammalian cells can proliferate well in the presence of PCL-DNS scaffolds and the nanocomposite scaffolds implanted in rats did not show any considerable adverse effects. Overall, the findings show that the developed novel air-jet spun PCL-DNS nanocomposite scaffolds can be used as cell supportive scaffolds for various tissue engineering applications.</p><h2>Other Information</h2><p dir="ltr">Published in: Colloids and Surfaces B: Biointerfaces<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.colsurfb.2022.112958" target="_blank">https://dx.doi.org/10.1016/j.colsurfb.2022.112958</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_550eff36156471b8d0579b22658fe6f3 |
| identifier_str_mv | 10.1016/j.colsurfb.2022.112958 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516424 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibilityRobin Augustine (3976964)Sumama Nuthana Kalva (17302906)Yogesh B. Dalvi (5938502)Ruby Varghese (5938514)Maneesh Chandran (17346856)Anwarul Hasan (1332066)EngineeringBiomedical engineeringChemical engineeringMaterials engineeringMechanical engineeringNanotechnologyTissue engineeringPolycaprolactoneNanodiamondAir-jet spinning<p dir="ltr">The development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. The widely used nanofiber fabrication methods like electrospinning are time consuming and the obtained nanofibrous scaffolds are generally consist of compactly packed fibers, which affect proper cell penetration. On the other hand, air-jet spinning is an upcoming, less explored alternative approach for generating loosely arranged nanofibrous scaffolds within short time. However, air-jet spun scaffolds show inferior mechanical properties due to loosely organized fibers. Herein, we report the fabrication and detailed characterization of polycaprolactone (PCL) tissue engineering scaffolds loaded with diamond nanosheets (DNS) by air-jet spinning. Our results showed that the inclusion of DNS could improve the mechanical strength of the scaffolds. In vitro biocompatibility, and in vivo implantation studies demonstrated that PCL-DNS scaffolds are highly biocompatible and are suitable for tissue engineering applications. Our studies showed that mammalian cells can proliferate well in the presence of PCL-DNS scaffolds and the nanocomposite scaffolds implanted in rats did not show any considerable adverse effects. Overall, the findings show that the developed novel air-jet spun PCL-DNS nanocomposite scaffolds can be used as cell supportive scaffolds for various tissue engineering applications.</p><h2>Other Information</h2><p dir="ltr">Published in: Colloids and Surfaces B: Biointerfaces<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.colsurfb.2022.112958" target="_blank">https://dx.doi.org/10.1016/j.colsurfb.2022.112958</a></p>2023-01-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.colsurfb.2022.112958https://figshare.com/articles/journal_contribution/Air-jet_spun_tissue_engineering_scaffolds_incorporated_with_diamond_nanosheets_with_improved_mechanical_strength_and_biocompatibility/24516424CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245164242023-01-01T00:00:00Z |
| spellingShingle | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility Robin Augustine (3976964) Engineering Biomedical engineering Chemical engineering Materials engineering Mechanical engineering Nanotechnology Tissue engineering Polycaprolactone Nanodiamond Air-jet spinning |
| status_str | publishedVersion |
| title | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| title_full | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| title_fullStr | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| title_full_unstemmed | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| title_short | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| title_sort | Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility |
| topic | Engineering Biomedical engineering Chemical engineering Materials engineering Mechanical engineering Nanotechnology Tissue engineering Polycaprolactone Nanodiamond Air-jet spinning |