Angiogenic biomaterials for diabetic wound healing: A review
<p>Diabetic wounds are a serious healthcare challenge, often lead to chronic ulcers, infections, and a high risk of amputation. Angiogenesis, the formation of new blood vessels, is crucial for supplying nutrients, oxygen, and growth factors necessary for effective wound healing. In diabetic wo...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513531526774784 |
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| author | Asad Ullah (4524541) |
| author2 | Shakera Mohsin (22927408) Mohammad Nawshad (22927411) Ken Ninez Nurpramesti Prinindya (22927414) Abdulla al Mamun (22927417) Maimoona Bukhari (22927420) Faizan Haider (22927423) Elsadig Mahdi (9967349) Anwarul Hasan (1332066) |
| author2_role | author author author author author author author author |
| author_facet | Asad Ullah (4524541) Shakera Mohsin (22927408) Mohammad Nawshad (22927411) Ken Ninez Nurpramesti Prinindya (22927414) Abdulla al Mamun (22927417) Maimoona Bukhari (22927420) Faizan Haider (22927423) Elsadig Mahdi (9967349) Anwarul Hasan (1332066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Asad Ullah (4524541) Shakera Mohsin (22927408) Mohammad Nawshad (22927411) Ken Ninez Nurpramesti Prinindya (22927414) Abdulla al Mamun (22927417) Maimoona Bukhari (22927420) Faizan Haider (22927423) Elsadig Mahdi (9967349) Anwarul Hasan (1332066) |
| dc.date.none.fl_str_mv | 2025-12-19T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.mtcomm.2025.114508 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Angiogenic_biomaterials_for_diabetic_wound_healing_A_review/30970690 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Wound healing Biomaterials Angiogenesis Diabetic wound healing Tissue engineering |
| dc.title.none.fl_str_mv | Angiogenic biomaterials for diabetic wound healing: A review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Diabetic wounds are a serious healthcare challenge, often lead to chronic ulcers, infections, and a high risk of amputation. Angiogenesis, the formation of new blood vessels, is crucial for supplying nutrients, oxygen, and growth factors necessary for effective wound healing. In diabetic wounds, impaired angiogenesis hinders the healing process, resulting in delayed tissue regeneration and prolonged wound closure. To induce angiogenesis, therapeutics like growth factors, cytokines, nitric oxide donors, and stem cells etc. have been utilized in wound healing but often face limitations such as rapid degradation, short half-life, and poor localized delivery, leading to reduced effectiveness. Biomaterials address these challenges by providing a controlled release platform that enhances the stability, bioavailability, and retention of these agents, ensuring prolonged therapeutic effects as well as creating a supportive environment for optimal angiogenesis. Therefore, this review explores the potential of biomaterials in addressing a major clinical challenge associated with diabetic wound healing. This review provides a comprehensive overview of current angiogenic therapeutics used to stimulate blood vessel formation in impaired tissues. It then explores biomaterial-based strategies engineered to enhance and sustain angiogenesis in diabetic wound environments. Finally, it discusses the key challenges associated with these approaches and outlines future prospects for developing more effective and clinical translatable treatments.</p><h2>Other Information</h2> <p> Published in: Materials Today Communications<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.mtcomm.2025.114508" target="_blank">https://dx.doi.org/10.1016/j.mtcomm.2025.114508</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5597611dd0c7335ac7ff6c32d08257de |
| identifier_str_mv | 10.1016/j.mtcomm.2025.114508 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30970690 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Angiogenic biomaterials for diabetic wound healing: A reviewAsad Ullah (4524541)Shakera Mohsin (22927408)Mohammad Nawshad (22927411)Ken Ninez Nurpramesti Prinindya (22927414)Abdulla al Mamun (22927417)Maimoona Bukhari (22927420)Faizan Haider (22927423)Elsadig Mahdi (9967349)Anwarul Hasan (1332066)Biomedical and clinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringWound healingBiomaterialsAngiogenesisDiabetic wound healingTissue engineering<p>Diabetic wounds are a serious healthcare challenge, often lead to chronic ulcers, infections, and a high risk of amputation. Angiogenesis, the formation of new blood vessels, is crucial for supplying nutrients, oxygen, and growth factors necessary for effective wound healing. In diabetic wounds, impaired angiogenesis hinders the healing process, resulting in delayed tissue regeneration and prolonged wound closure. To induce angiogenesis, therapeutics like growth factors, cytokines, nitric oxide donors, and stem cells etc. have been utilized in wound healing but often face limitations such as rapid degradation, short half-life, and poor localized delivery, leading to reduced effectiveness. Biomaterials address these challenges by providing a controlled release platform that enhances the stability, bioavailability, and retention of these agents, ensuring prolonged therapeutic effects as well as creating a supportive environment for optimal angiogenesis. Therefore, this review explores the potential of biomaterials in addressing a major clinical challenge associated with diabetic wound healing. This review provides a comprehensive overview of current angiogenic therapeutics used to stimulate blood vessel formation in impaired tissues. It then explores biomaterial-based strategies engineered to enhance and sustain angiogenesis in diabetic wound environments. Finally, it discusses the key challenges associated with these approaches and outlines future prospects for developing more effective and clinical translatable treatments.</p><h2>Other Information</h2> <p> Published in: Materials Today Communications<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.mtcomm.2025.114508" target="_blank">https://dx.doi.org/10.1016/j.mtcomm.2025.114508</a></p>2025-12-19T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.mtcomm.2025.114508https://figshare.com/articles/journal_contribution/Angiogenic_biomaterials_for_diabetic_wound_healing_A_review/30970690CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/309706902025-12-19T18:00:00Z |
| spellingShingle | Angiogenic biomaterials for diabetic wound healing: A review Asad Ullah (4524541) Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Wound healing Biomaterials Angiogenesis Diabetic wound healing Tissue engineering |
| status_str | publishedVersion |
| title | Angiogenic biomaterials for diabetic wound healing: A review |
| title_full | Angiogenic biomaterials for diabetic wound healing: A review |
| title_fullStr | Angiogenic biomaterials for diabetic wound healing: A review |
| title_full_unstemmed | Angiogenic biomaterials for diabetic wound healing: A review |
| title_short | Angiogenic biomaterials for diabetic wound healing: A review |
| title_sort | Angiogenic biomaterials for diabetic wound healing: A review |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Wound healing Biomaterials Angiogenesis Diabetic wound healing Tissue engineering |