DNA methylation profiling in Trisomy 21 females with and without breast cancer
<h3>Background</h3><p dir="ltr">Down Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2023
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| _version_ | 1864513520770482176 |
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| author | Yosra Bejaoui (8552574) |
| author2 | Sara Alresheq (16614792) Sophie Durand (5639963) Marie Vilaire-Meunier (16614795) Louise Maillebouis (16614798) Ayman Al Haj Zen (19438033) André Mégarbané (5649685) Nady El Hajj (8552577) |
| author2_role | author author author author author author author |
| author_facet | Yosra Bejaoui (8552574) Sara Alresheq (16614792) Sophie Durand (5639963) Marie Vilaire-Meunier (16614795) Louise Maillebouis (16614798) Ayman Al Haj Zen (19438033) André Mégarbané (5649685) Nady El Hajj (8552577) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yosra Bejaoui (8552574) Sara Alresheq (16614792) Sophie Durand (5639963) Marie Vilaire-Meunier (16614795) Louise Maillebouis (16614798) Ayman Al Haj Zen (19438033) André Mégarbané (5649685) Nady El Hajj (8552577) |
| dc.date.none.fl_str_mv | 2023-07-19T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2023.1203483 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/DNA_methylation_profiling_in_Trisomy_21_females_with_and_without_breast_cancer/26772196 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Down syndrome breast cancer DNA methylation epigenetics Trisomy 21 |
| dc.title.none.fl_str_mv | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Down Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acute myeloid leukemia and acute lymphoblastic leukemia.</p><h3>Methods</h3><p dir="ltr">In this study, we investigated DNA methylation signatures and epigenetic aging in DS individuals with and without breast cancer. We analyzed DNA methylation patterns in Trisomy 21 (T21) individuals without breast cancer (T21-BCF) and DS individuals with breast cancer (T21-BC), using the Infinium Methylation EPIC BeadChip array.</p><h3>Results</h3><p dir="ltr">Our results revealed several differentially methylated sites and regions in the T21-BC patients that were associated with changes in gene expression. The differentially methylated CpG sites were enriched for processes related to serine-type peptidase activity, epithelial cell development, GTPase activity, bicellular tight junction, Ras protein signal transduction, etc. On the other hand, the epigenetic age acceleration analysis showed no difference between T21-BC and T21-BCF patients.</p><h3>Conclusions</h3><p dir="ltr">This is the first study to investigate DNA methylation changes in Down syndrome women with and without breast cancer and it could help shed light on factors that protect against breast cancer in DS.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2023.1203483" target="_blank">https://dx.doi.org/10.3389/fonc.2023.1203483</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_57afbcffc4110a8dc9c552b1aa612082 |
| identifier_str_mv | 10.3389/fonc.2023.1203483 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26772196 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | DNA methylation profiling in Trisomy 21 females with and without breast cancerYosra Bejaoui (8552574)Sara Alresheq (16614792)Sophie Durand (5639963)Marie Vilaire-Meunier (16614795)Louise Maillebouis (16614798)Ayman Al Haj Zen (19438033)André Mégarbané (5649685)Nady El Hajj (8552577)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesOncology and carcinogenesisDown syndromebreast cancerDNA methylationepigeneticsTrisomy 21<h3>Background</h3><p dir="ltr">Down Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acute myeloid leukemia and acute lymphoblastic leukemia.</p><h3>Methods</h3><p dir="ltr">In this study, we investigated DNA methylation signatures and epigenetic aging in DS individuals with and without breast cancer. We analyzed DNA methylation patterns in Trisomy 21 (T21) individuals without breast cancer (T21-BCF) and DS individuals with breast cancer (T21-BC), using the Infinium Methylation EPIC BeadChip array.</p><h3>Results</h3><p dir="ltr">Our results revealed several differentially methylated sites and regions in the T21-BC patients that were associated with changes in gene expression. The differentially methylated CpG sites were enriched for processes related to serine-type peptidase activity, epithelial cell development, GTPase activity, bicellular tight junction, Ras protein signal transduction, etc. On the other hand, the epigenetic age acceleration analysis showed no difference between T21-BC and T21-BCF patients.</p><h3>Conclusions</h3><p dir="ltr">This is the first study to investigate DNA methylation changes in Down syndrome women with and without breast cancer and it could help shed light on factors that protect against breast cancer in DS.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2023.1203483" target="_blank">https://dx.doi.org/10.3389/fonc.2023.1203483</a></p>2023-07-19T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fonc.2023.1203483https://figshare.com/articles/journal_contribution/DNA_methylation_profiling_in_Trisomy_21_females_with_and_without_breast_cancer/26772196CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/267721962023-07-19T09:00:00Z |
| spellingShingle | DNA methylation profiling in Trisomy 21 females with and without breast cancer Yosra Bejaoui (8552574) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Down syndrome breast cancer DNA methylation epigenetics Trisomy 21 |
| status_str | publishedVersion |
| title | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| title_full | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| title_fullStr | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| title_full_unstemmed | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| title_short | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| title_sort | DNA methylation profiling in Trisomy 21 females with and without breast cancer |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Down syndrome breast cancer DNA methylation epigenetics Trisomy 21 |