Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers
<p dir="ltr">Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for cancer diagnosis and treatment. Long non-coding RNAs (lncRNAs) are RNA molecules (> 200 nt) that are not translated into protein, and interact with DN...
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2023
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| _version_ | 1864513530545307648 |
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| author | Maryam Farzaneh (17788460) |
| author2 | Mahrokh Abouali Gale Dari (17788463) Amir Anbiyaiee (17788466) Sajad Najafi (8523714) Dian Dayer (17788469) Abdolah Mousavi Salehi (17788472) Mona Keivan (17788475) Mehri Ghafourian (17788478) Shahab Uddin (154400) Shirin Azizidoost (15369871) |
| author2_role | author author author author author author author author author |
| author_facet | Maryam Farzaneh (17788460) Mahrokh Abouali Gale Dari (17788463) Amir Anbiyaiee (17788466) Sajad Najafi (8523714) Dian Dayer (17788469) Abdolah Mousavi Salehi (17788472) Mona Keivan (17788475) Mehri Ghafourian (17788478) Shahab Uddin (154400) Shirin Azizidoost (15369871) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maryam Farzaneh (17788460) Mahrokh Abouali Gale Dari (17788463) Amir Anbiyaiee (17788466) Sajad Najafi (8523714) Dian Dayer (17788469) Abdolah Mousavi Salehi (17788472) Mona Keivan (17788475) Mehri Ghafourian (17788478) Shahab Uddin (154400) Shirin Azizidoost (15369871) |
| dc.date.none.fl_str_mv | 2023-06-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s12079-023-00746-x |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Emerging_roles_of_the_long_non-coding_RNA_NEAT1_in_gynecologic_cancers/24998582 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine LncRNAs NEAT1 Gynecologic cancer Tumorigenesis Biomarker |
| dc.title.none.fl_str_mv | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for cancer diagnosis and treatment. Long non-coding RNAs (lncRNAs) are RNA molecules (> 200 nt) that are not translated into protein, and interact with DNA, RNA, and proteins. LncRNAs were found to play pivotal roles in cancer tumorigenesis and progression. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a lncRNA that mediates cell proliferation, migration, and EMT in gynecologic cancers by targeting several miRNAs/mRNA axes. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of breast, ovarian, cervical, and endometrial cancers. In this narrative review, we summarized various NEAT1-related signaling pathways that are critical in gynecologic cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cell Communication and Signaling<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s12079-023-00746-x" target="_blank">https://dx.doi.org/10.1007/s12079-023-00746-x</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_57d7e0a80d1b4224336afb054d4c981b |
| identifier_str_mv | 10.1007/s12079-023-00746-x |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24998582 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancersMaryam Farzaneh (17788460)Mahrokh Abouali Gale Dari (17788463)Amir Anbiyaiee (17788466)Sajad Najafi (8523714)Dian Dayer (17788469)Abdolah Mousavi Salehi (17788472)Mona Keivan (17788475)Mehri Ghafourian (17788478)Shahab Uddin (154400)Shirin Azizidoost (15369871)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesOncology and carcinogenesisReproductive medicineLncRNAsNEAT1Gynecologic cancerTumorigenesisBiomarker<p dir="ltr">Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for cancer diagnosis and treatment. Long non-coding RNAs (lncRNAs) are RNA molecules (> 200 nt) that are not translated into protein, and interact with DNA, RNA, and proteins. LncRNAs were found to play pivotal roles in cancer tumorigenesis and progression. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a lncRNA that mediates cell proliferation, migration, and EMT in gynecologic cancers by targeting several miRNAs/mRNA axes. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of breast, ovarian, cervical, and endometrial cancers. In this narrative review, we summarized various NEAT1-related signaling pathways that are critical in gynecologic cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cell Communication and Signaling<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s12079-023-00746-x" target="_blank">https://dx.doi.org/10.1007/s12079-023-00746-x</a></p>2023-06-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s12079-023-00746-xhttps://figshare.com/articles/journal_contribution/Emerging_roles_of_the_long_non-coding_RNA_NEAT1_in_gynecologic_cancers/24998582CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249985822023-06-13T03:00:00Z |
| spellingShingle | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers Maryam Farzaneh (17788460) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine LncRNAs NEAT1 Gynecologic cancer Tumorigenesis Biomarker |
| status_str | publishedVersion |
| title | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| title_full | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| title_fullStr | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| title_full_unstemmed | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| title_short | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| title_sort | Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine LncRNAs NEAT1 Gynecologic cancer Tumorigenesis Biomarker |