Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation

<p dir="ltr">The precise mechanism of macrolide antibiotic azithromycin (AZM) mediated CD4+ T cell suppression is not fully understood. Given the crucial role of co-stimulatory signaling in T-lymphocyte function, we tested in vitro effects of AZM on two of the most extensively invest...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Abdul Wahid Ansari (9442697) (author)
مؤلفون آخرون:	Fareed Ahmad (134672) (author), Thesni Raheed (17017779) (author), Anh Jochebeth (17017782) (author), Jericha Miles Pamiloza Mateo (17017785) (author), Nabeel Abdulrahman (725914) (author), Elizabeth Febu Joy (17017788) (author), Majid Ali Alam (17017791) (author), Joerg Buddenkotte (6293584) (author), Rifat Akram Hamoudi (9442709) (author), Martin Steinhoff (5340194) (author)
منشور في:	2023
الموضوعات:	Biomedical and clinical sciences Immunology Pharmacology and pharmaceutical sciences Azithromycin T cells ICOS OX40 Proliferation mTOR
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation

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