Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
<p>Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehen...
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2023
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| _version_ | 1864513532072034304 |
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| author | Kresimir Tomic (17632194) |
| author2 | Dragana Karan Krizanac (17632197) Faruk Skenderi (6616190) Kristina Krpina (17632200) Andrea Carapina Bilic (17632203) Kristina Galic (17632206) Zoran Gatalica (3353003) Semir Vranic (3353012) |
| author2_role | author author author author author author author |
| author_facet | Kresimir Tomic (17632194) Dragana Karan Krizanac (17632197) Faruk Skenderi (6616190) Kristina Krpina (17632200) Andrea Carapina Bilic (17632203) Kristina Galic (17632206) Zoran Gatalica (3353003) Semir Vranic (3353012) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kresimir Tomic (17632194) Dragana Karan Krizanac (17632197) Faruk Skenderi (6616190) Kristina Krpina (17632200) Andrea Carapina Bilic (17632203) Kristina Galic (17632206) Zoran Gatalica (3353003) Semir Vranic (3353012) |
| dc.date.none.fl_str_mv | 2023-09-26T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.rmcr.2023.101920 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Comprehensive_genomic_profiling_of_a_metastatic_small_cell_lung_carcinoma_with_a_complete_and_long-term_response_to_atezolizumab_A_case_report/24805182 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Lung cancer Small cell lung cancer Immunotherapy Atezolizumab Genomic profiling |
| dc.title.none.fl_str_mv | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC.</p><h2>Other Information</h2> <p> Published in: Respiratory Medicine Case Reports<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.rmcr.2023.101920" target="_blank">https://dx.doi.org/10.1016/j.rmcr.2023.101920</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_58e70751b18c2cd8c0a3cf54df031ee9 |
| identifier_str_mv | 10.1016/j.rmcr.2023.101920 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24805182 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case reportKresimir Tomic (17632194)Dragana Karan Krizanac (17632197)Faruk Skenderi (6616190)Kristina Krpina (17632200)Andrea Carapina Bilic (17632203)Kristina Galic (17632206)Zoran Gatalica (3353003)Semir Vranic (3353012)Biomedical and clinical sciencesCardiovascular medicine and haematologyOncology and carcinogenesisPharmacology and pharmaceutical sciencesLung cancerSmall cell lung cancerImmunotherapyAtezolizumabGenomic profiling<p>Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC.</p><h2>Other Information</h2> <p> Published in: Respiratory Medicine Case Reports<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.rmcr.2023.101920" target="_blank">https://dx.doi.org/10.1016/j.rmcr.2023.101920</a></p>2023-09-26T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.rmcr.2023.101920https://figshare.com/articles/journal_contribution/Comprehensive_genomic_profiling_of_a_metastatic_small_cell_lung_carcinoma_with_a_complete_and_long-term_response_to_atezolizumab_A_case_report/24805182CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/248051822023-09-26T06:00:00Z |
| spellingShingle | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report Kresimir Tomic (17632194) Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Lung cancer Small cell lung cancer Immunotherapy Atezolizumab Genomic profiling |
| status_str | publishedVersion |
| title | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| title_full | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| title_fullStr | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| title_full_unstemmed | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| title_short | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| title_sort | Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Lung cancer Small cell lung cancer Immunotherapy Atezolizumab Genomic profiling |