Biochemical and cellular basis of oxidative stress: Implications for disease onset
<p dir="ltr">Cellular oxidation–reduction (redox) systems, which encompass pro‐ and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular imbalances between the pro‐ and antioxidant moietie...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , |
| Published: |
2023
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513530997243904 |
|---|---|
| author | Karl Aramouni (17746956) |
| author2 | Roland Assaf (17746959) Abdullah Shaito (17746962) Manal Fardoun (16328847) Maha Al‐Asmakh (17746965) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| author2_role | author author author author author author |
| author_facet | Karl Aramouni (17746956) Roland Assaf (17746959) Abdullah Shaito (17746962) Manal Fardoun (16328847) Maha Al‐Asmakh (17746965) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Karl Aramouni (17746956) Roland Assaf (17746959) Abdullah Shaito (17746962) Manal Fardoun (16328847) Maha Al‐Asmakh (17746965) Amirhossein Sahebkar (1452028) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2023-07-12T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/jcp.31071 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Biochemical_and_cellular_basis_of_oxidative_stress_Implications_for_disease_onset/24954762 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical physiology antioxidants NFκB NOX Nrf2 peroxiredoxin ROS |
| dc.title.none.fl_str_mv | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cellular oxidation–reduction (redox) systems, which encompass pro‐ and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular imbalances between the pro‐ and antioxidant moieties, leading to a state of oxidative stress. Long‐lasting oxidative stress can manifest clinically as a variety of chronic illnesses including cancers, neurodegenerative disorders, cardiovascular disease, and metabolic diseases like diabetes. As such, this review investigates the impact of oxidative stress on the human body with emphasis on the underlying oxidants, mechanisms, and pathways. It also discusses the available antioxidant defense mechanisms. The cellular monitoring and regulatory systems that ensure a balanced oxidative cellular environment are detailed. We critically discuss the notion of oxidants as a double‐edged sword, being signaling messengers at low physiological concentrations but causative agents of oxidative stress when overproduced. In this regard, the review also presents strategies employed by oxidants including redox signaling and activation of transcriptional programs such as those mediated by the Nrf2/Keap1 and NFk signaling. Likewise, redox molecular switches of peroxiredoxin and DJ‐1 and the proteins they regulate are presented. The review concludes that a thorough comprehension of cellular redox systems is essential to develop the evolving field of redox medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31071" target="_blank">https://dx.doi.org/10.1002/jcp.31071</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_595cb81370d17f1c82755851dd8fbf6c |
| identifier_str_mv | 10.1002/jcp.31071 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24954762 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Biochemical and cellular basis of oxidative stress: Implications for disease onsetKarl Aramouni (17746956)Roland Assaf (17746959)Abdullah Shaito (17746962)Manal Fardoun (16328847)Maha Al‐Asmakh (17746965)Amirhossein Sahebkar (1452028)Ali H. Eid (5461829)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesMedical physiologyantioxidantsNFκBNOXNrf2peroxiredoxinROS<p dir="ltr">Cellular oxidation–reduction (redox) systems, which encompass pro‐ and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular imbalances between the pro‐ and antioxidant moieties, leading to a state of oxidative stress. Long‐lasting oxidative stress can manifest clinically as a variety of chronic illnesses including cancers, neurodegenerative disorders, cardiovascular disease, and metabolic diseases like diabetes. As such, this review investigates the impact of oxidative stress on the human body with emphasis on the underlying oxidants, mechanisms, and pathways. It also discusses the available antioxidant defense mechanisms. The cellular monitoring and regulatory systems that ensure a balanced oxidative cellular environment are detailed. We critically discuss the notion of oxidants as a double‐edged sword, being signaling messengers at low physiological concentrations but causative agents of oxidative stress when overproduced. In this regard, the review also presents strategies employed by oxidants including redox signaling and activation of transcriptional programs such as those mediated by the Nrf2/Keap1 and NFk signaling. Likewise, redox molecular switches of peroxiredoxin and DJ‐1 and the proteins they regulate are presented. The review concludes that a thorough comprehension of cellular redox systems is essential to develop the evolving field of redox medicine.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31071" target="_blank">https://dx.doi.org/10.1002/jcp.31071</a></p>2023-07-12T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/jcp.31071https://figshare.com/articles/journal_contribution/Biochemical_and_cellular_basis_of_oxidative_stress_Implications_for_disease_onset/24954762CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249547622023-07-12T03:00:00Z |
| spellingShingle | Biochemical and cellular basis of oxidative stress: Implications for disease onset Karl Aramouni (17746956) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical physiology antioxidants NFκB NOX Nrf2 peroxiredoxin ROS |
| status_str | publishedVersion |
| title | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| title_full | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| title_fullStr | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| title_full_unstemmed | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| title_short | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| title_sort | Biochemical and cellular basis of oxidative stress: Implications for disease onset |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical physiology antioxidants NFκB NOX Nrf2 peroxiredoxin ROS |