Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments
<div><p>Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous mon...
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2022
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| _version_ | 1864513519728197632 |
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| author | Saife N. Lone (18278770) |
| author2 | Sabah Nisar (12561961) Tariq Masoodi (8117702) Mayank Singh (793077) Arshi Rizwan (18278773) Sheema Hashem (14150961) Wael El-Rifai (303374) Davide Bedognetti (2632474) Surinder K. Batra (7548596) Mohammad Haris (564809) Ajaz A. Bhat (12984701) Muzafar A. Macha (11605200) |
| author2_role | author author author author author author author author author author author |
| author_facet | Saife N. Lone (18278770) Sabah Nisar (12561961) Tariq Masoodi (8117702) Mayank Singh (793077) Arshi Rizwan (18278773) Sheema Hashem (14150961) Wael El-Rifai (303374) Davide Bedognetti (2632474) Surinder K. Batra (7548596) Mohammad Haris (564809) Ajaz A. Bhat (12984701) Muzafar A. Macha (11605200) |
| author_role | author |
| dc.creator.none.fl_str_mv | Saife N. Lone (18278770) Sabah Nisar (12561961) Tariq Masoodi (8117702) Mayank Singh (793077) Arshi Rizwan (18278773) Sheema Hashem (14150961) Wael El-Rifai (303374) Davide Bedognetti (2632474) Surinder K. Batra (7548596) Mohammad Haris (564809) Ajaz A. Bhat (12984701) Muzafar A. Macha (11605200) |
| dc.date.none.fl_str_mv | 2022-03-18T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12943-022-01543-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Liquid_biopsy_a_step_closer_to_transform_diagnosis_prognosis_and_future_of_cancer_treatments/25513894 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Cancer Circulating tumor cells Circulating tumor DNA Tumor extracellular vesicles Noninvasive tumor detection Precision medicine Cancer diagnosis |
| dc.title.none.fl_str_mv | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of isolating tumor-derived entities like circulating tumor cells, circulating tumor DNA, tumor extracellular vesicles, etc., present in the body fluids of patients with cancer, followed by an analysis of genomic and proteomic data contained within them. Methods for isolation and analysis of liquid biopsies have rapidly evolved over the past few years as described in the review, thus providing greater details about tumor characteristics such as tumor progression, tumor staging, heterogeneity, gene mutations, and clonal evolution, etc. Liquid biopsies from cancer patients have opened up newer avenues in detection and continuous monitoring, treatment based on precision medicine, and screening of markers for therapeutic resistance. Though the technology of liquid biopsies is still evolving, its non-invasive nature promises to open new eras in clinical oncology. The purpose of this review is to provide an overview of the current methodologies involved in liquid biopsies and their application in isolating tumor markers for detection, prognosis, and monitoring cancer treatment outcomes.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12943-022-01543-7" target="_blank">https://dx.doi.org/10.1186/s12943-022-01543-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5a6a4ccd9b3a11212e16d24d8ecb1b5b |
| identifier_str_mv | 10.1186/s12943-022-01543-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25513894 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatmentsSaife N. Lone (18278770)Sabah Nisar (12561961)Tariq Masoodi (8117702)Mayank Singh (793077)Arshi Rizwan (18278773)Sheema Hashem (14150961)Wael El-Rifai (303374)Davide Bedognetti (2632474)Surinder K. Batra (7548596)Mohammad Haris (564809)Ajaz A. Bhat (12984701)Muzafar A. Macha (11605200)Biomedical and clinical sciencesOncology and carcinogenesisLiquid biopsyCancerCirculating tumor cellsCirculating tumor DNATumor extracellular vesiclesNoninvasive tumor detectionPrecision medicine Cancer diagnosis<div><p>Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of isolating tumor-derived entities like circulating tumor cells, circulating tumor DNA, tumor extracellular vesicles, etc., present in the body fluids of patients with cancer, followed by an analysis of genomic and proteomic data contained within them. Methods for isolation and analysis of liquid biopsies have rapidly evolved over the past few years as described in the review, thus providing greater details about tumor characteristics such as tumor progression, tumor staging, heterogeneity, gene mutations, and clonal evolution, etc. Liquid biopsies from cancer patients have opened up newer avenues in detection and continuous monitoring, treatment based on precision medicine, and screening of markers for therapeutic resistance. Though the technology of liquid biopsies is still evolving, its non-invasive nature promises to open new eras in clinical oncology. The purpose of this review is to provide an overview of the current methodologies involved in liquid biopsies and their application in isolating tumor markers for detection, prognosis, and monitoring cancer treatment outcomes.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Molecular Cancer<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12943-022-01543-7" target="_blank">https://dx.doi.org/10.1186/s12943-022-01543-7</a></p>2022-03-18T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12943-022-01543-7https://figshare.com/articles/journal_contribution/Liquid_biopsy_a_step_closer_to_transform_diagnosis_prognosis_and_future_of_cancer_treatments/25513894CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/255138942022-03-18T03:00:00Z |
| spellingShingle | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments Saife N. Lone (18278770) Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Cancer Circulating tumor cells Circulating tumor DNA Tumor extracellular vesicles Noninvasive tumor detection Precision medicine Cancer diagnosis |
| status_str | publishedVersion |
| title | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_full | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_fullStr | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_full_unstemmed | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_short | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_sort | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Liquid biopsy Cancer Circulating tumor cells Circulating tumor DNA Tumor extracellular vesicles Noninvasive tumor detection Precision medicine Cancer diagnosis |