Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

<h3>Background</h3><p dir="ltr">Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but drug dis...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Kevin S. Chen (9201767) (author)
مؤلفون آخرون: Krystal Menezes (11692035) (author), Jarlath B. Rodgers (2873462) (author), Darren M. O’Hara (9201761) (author), Nhat Tran (10733310) (author), Kazuko Fujisawa (11692038) (author), Seiya Ishikura (11692041) (author), Shahin Khodaei (11692044) (author), Hien Chau (355945) (author), Anna Cranston (11692047) (author), Minesh Kapadia (582056) (author), Grishma Pawar (10666899) (author), Susan Ping (11692050) (author), Aldis Krizus (4253764) (author), Alix Lacoste (11692053) (author), Scott Spangler (4499941) (author), Naomi P. Visanji (11692056) (author), Connie Marras (3540161) (author), Nour K. Majbour (8809316) (author), Omar M. A. El-Agnaf (8809331) (author), Andres M. Lozano (8627790) (author), Joseph Culotti (11692059) (author), Satoshi Suo (446967) (author), William S. Ryu (8630016) (author), Suneil K. Kalia (9201773) (author), Lorraine V. Kalia (9201770) (author)
منشور في: 2021
الموضوعات:
Biomedical and clinical sciences
Neurosciences
Pharmacology and pharmaceutical sciences
Information and computing sciences
Machine learning
Alpha-synuclein
Animal model
Artificial intelligence
Drug discovery
Natural language processing
Neurodegeneration
Oligomers
Parkinson’s disease
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

مواد مشابهة