Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

<h3>Background</h3><p dir="ltr">Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but drug dis...

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Main Author:	Kevin S. Chen (9201767) (author)
Other Authors:	Krystal Menezes (11692035) (author), Jarlath B. Rodgers (2873462) (author), Darren M. O’Hara (9201761) (author), Nhat Tran (10733310) (author), Kazuko Fujisawa (11692038) (author), Seiya Ishikura (11692041) (author), Shahin Khodaei (11692044) (author), Hien Chau (355945) (author), Anna Cranston (11692047) (author), Minesh Kapadia (582056) (author), Grishma Pawar (10666899) (author), Susan Ping (11692050) (author), Aldis Krizus (4253764) (author), Alix Lacoste (11692053) (author), Scott Spangler (4499941) (author), Naomi P. Visanji (11692056) (author), Connie Marras (3540161) (author), Nour K. Majbour (8809316) (author), Omar M. A. El-Agnaf (8809331) (author), Andres M. Lozano (8627790) (author), Joseph Culotti (11692059) (author), Satoshi Suo (446967) (author), William S. Ryu (8630016) (author), Suneil K. Kalia (9201773) (author), Lorraine V. Kalia (9201770) (author)
Published:	2021
Subjects:	Biomedical and clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Information and computing sciences Machine learning Alpha-synuclein Animal model Artificial intelligence Drug discovery Natural language processing Neurodegeneration Oligomers Parkinson’s disease
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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

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