Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

<p dir="ltr">Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and <i>in vitro</i> studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a mostly incurable malignan...

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Main Author: Sabah Akhtar (5809925) (author)
Other Authors: Iman W. Achkar (4246141) (author), Kodappully S. Siveen (4246150) (author), Shilpa Kuttikrishnan (3520079) (author), Kirti S. Prabhu (4246144) (author), Abdul Q. Khan (14153247) (author), Eiman I. Ahmed (6595514) (author), Fairooz Sahir (6595517) (author), Jayakumar Jerobin (6595520) (author), Afsheen Raza (492657) (author), Maysaloun Merhi (4246147) (author), Hesham M. Elsabah (6595523) (author), Ruba Taha (6595526) (author), Halima El Omri (6595529) (author), Hatem Zayed (835448) (author), Said Dermime (79420) (author), Martin Steinhoff (5340194) (author), Shahab Uddin (154400) (author)
Published: 2019
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
apoptosis
caspases
STAT3
sanguinarine
multiple myeloma
hematological malignancy
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