Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication
<p dir="ltr">Clomiphene citrate is commonly prescribed to treat male hypogonadism due to its ability to increase endogenous testosterone levels while preserving fertility. Although it is generally considered safe, and rare serious cardiovascular events have been reported. We present...
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2025
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| _version_ | 1864513533558915072 |
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| author | Zubair Shahid (16441927) |
| author2 | Gi Eun Kim (18185908) Tariq Mousa (22504286) Ziad AlSehli (22504289) Awad Al-Qahtani (315456) |
| author2_role | author author author author |
| author_facet | Zubair Shahid (16441927) Gi Eun Kim (18185908) Tariq Mousa (22504286) Ziad AlSehli (22504289) Awad Al-Qahtani (315456) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zubair Shahid (16441927) Gi Eun Kim (18185908) Tariq Mousa (22504286) Ziad AlSehli (22504289) Awad Al-Qahtani (315456) |
| dc.date.none.fl_str_mv | 2025-07-09T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1177/00368504251349392 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Clomiphene-induced_myocardial_infarction_in_a_young_male_A_case_report_of_a_rare_cardiovascular_complication/30455930 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Reproductive medicine Clomiphene citrate male hypogonadism myocardial infarction drug-induced thrombosis thromboembolism |
| dc.title.none.fl_str_mv | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Clomiphene citrate is commonly prescribed to treat male hypogonadism due to its ability to increase endogenous testosterone levels while preserving fertility. Although it is generally considered safe, and rare serious cardiovascular events have been reported. We present the case of a male in his early 30s with no known cardiovascular risk factors who developed an acute inferior-posterior ST-elevation myocardial infarction while taking clomiphene for infertility. Coronary angiography revealed complete occlusion of the distal right coronary artery due to a heavy thrombus burden, with no underlying atherosclerotic disease. The patient was successfully treated with aspiration thrombectomy and conservative medical management. This case underscores a potential, albeit rare, association between clomiphene use and myocardial infarction, warranting caution in its use—even among individuals without traditional cardiovascular risk factors.</p><h2>Other Information</h2><p dir="ltr">Published in: Science Progress<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1177/00368504251349392" target="_blank">https://dx.doi.org/10.1177/00368504251349392</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5c5e4f46e57645d7e0264f55d452c5b0 |
| identifier_str_mv | 10.1177/00368504251349392 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30455930 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complicationZubair Shahid (16441927)Gi Eun Kim (18185908)Tariq Mousa (22504286)Ziad AlSehli (22504289)Awad Al-Qahtani (315456)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesReproductive medicineClomiphene citratemale hypogonadismmyocardial infarctiondrug-induced thrombosisthromboembolism<p dir="ltr">Clomiphene citrate is commonly prescribed to treat male hypogonadism due to its ability to increase endogenous testosterone levels while preserving fertility. Although it is generally considered safe, and rare serious cardiovascular events have been reported. We present the case of a male in his early 30s with no known cardiovascular risk factors who developed an acute inferior-posterior ST-elevation myocardial infarction while taking clomiphene for infertility. Coronary angiography revealed complete occlusion of the distal right coronary artery due to a heavy thrombus burden, with no underlying atherosclerotic disease. The patient was successfully treated with aspiration thrombectomy and conservative medical management. This case underscores a potential, albeit rare, association between clomiphene use and myocardial infarction, warranting caution in its use—even among individuals without traditional cardiovascular risk factors.</p><h2>Other Information</h2><p dir="ltr">Published in: Science Progress<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1177/00368504251349392" target="_blank">https://dx.doi.org/10.1177/00368504251349392</a></p>2025-07-09T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1177/00368504251349392https://figshare.com/articles/journal_contribution/Clomiphene-induced_myocardial_infarction_in_a_young_male_A_case_report_of_a_rare_cardiovascular_complication/30455930CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304559302025-07-09T03:00:00Z |
| spellingShingle | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication Zubair Shahid (16441927) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Reproductive medicine Clomiphene citrate male hypogonadism myocardial infarction drug-induced thrombosis thromboembolism |
| status_str | publishedVersion |
| title | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| title_full | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| title_fullStr | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| title_full_unstemmed | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| title_short | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| title_sort | Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Reproductive medicine Clomiphene citrate male hypogonadism myocardial infarction drug-induced thrombosis thromboembolism |