Genetic polymorphisms influencing antihypertensive drug responses
<p dir="ltr">Hypertension is a major contributor to cardiovascular disease and its associated morbidity and mortality. The low efficacy observed with some anti‐hypertensive therapies has been attributed partly to inter‐individual genetic variability. This paper reviews the major find...
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2024
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| _version_ | 1864513538006974464 |
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| author | Jana El Cheikh (22330738) |
| author2 | Fouad Hamed (22330741) Hana Rifi (22330744) Ali H. Dakroub (22303819) Ali Hussein Eid (13355211) |
| author2_role | author author author author |
| author_facet | Jana El Cheikh (22330738) Fouad Hamed (22330741) Hana Rifi (22330744) Ali H. Dakroub (22303819) Ali Hussein Eid (13355211) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jana El Cheikh (22330738) Fouad Hamed (22330741) Hana Rifi (22330744) Ali H. Dakroub (22303819) Ali Hussein Eid (13355211) |
| dc.date.none.fl_str_mv | 2024-12-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/bph.17414 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Genetic_polymorphisms_influencing_antihypertensive_drug_responses/30234382 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences ACE inhibitors angiotensin receptor blockers calcium channel blockers cardiovascular disease diuretics hypertension pharmacogenomics β-adrenoceptor blockers |
| dc.title.none.fl_str_mv | Genetic polymorphisms influencing antihypertensive drug responses |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Hypertension is a major contributor to cardiovascular disease and its associated morbidity and mortality. The low efficacy observed with some anti‐hypertensive therapies has been attributed partly to inter‐individual genetic variability. This paper reviews the major findings regarding these genetic variabilities that modulate responses to anti‐hypertensive therapies such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, calcium channel blockers (CCBs) and β‐adrenoceptor blockers. The importance of studying these genetic polymorphisms stems from the goal to optimise anti‐hypertensive therapy for each individual patient, aiming for the highest efficacy and lowest risk of adverse effects. It is important to recognise that environmental and epigenetic factors can contribute to the observed variations in drug responses. Owing to the multigenic and multifactorial nature of drug responses, further research is crucial for translating these findings into clinical practice and the establishment of reliable recommendations.</p><h2>Other Information</h2><p dir="ltr">Published in: British Journal of Pharmacology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/bph.17414" target="_blank">https://dx.doi.org/10.1111/bph.17414</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5dd4a297b899ef5809821391442c5103 |
| identifier_str_mv | 10.1111/bph.17414 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30234382 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Genetic polymorphisms influencing antihypertensive drug responsesJana El Cheikh (22330738)Fouad Hamed (22330741)Hana Rifi (22330744)Ali H. Dakroub (22303819)Ali Hussein Eid (13355211)Biological sciencesGeneticsBiomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesACE inhibitorsangiotensin receptor blockerscalcium channel blockerscardiovascular diseasediureticshypertensionpharmacogenomicsβ-adrenoceptor blockers<p dir="ltr">Hypertension is a major contributor to cardiovascular disease and its associated morbidity and mortality. The low efficacy observed with some anti‐hypertensive therapies has been attributed partly to inter‐individual genetic variability. This paper reviews the major findings regarding these genetic variabilities that modulate responses to anti‐hypertensive therapies such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, calcium channel blockers (CCBs) and β‐adrenoceptor blockers. The importance of studying these genetic polymorphisms stems from the goal to optimise anti‐hypertensive therapy for each individual patient, aiming for the highest efficacy and lowest risk of adverse effects. It is important to recognise that environmental and epigenetic factors can contribute to the observed variations in drug responses. Owing to the multigenic and multifactorial nature of drug responses, further research is crucial for translating these findings into clinical practice and the establishment of reliable recommendations.</p><h2>Other Information</h2><p dir="ltr">Published in: British Journal of Pharmacology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/bph.17414" target="_blank">https://dx.doi.org/10.1111/bph.17414</a></p>2024-12-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/bph.17414https://figshare.com/articles/journal_contribution/Genetic_polymorphisms_influencing_antihypertensive_drug_responses/30234382CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302343822024-12-03T03:00:00Z |
| spellingShingle | Genetic polymorphisms influencing antihypertensive drug responses Jana El Cheikh (22330738) Biological sciences Genetics Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences ACE inhibitors angiotensin receptor blockers calcium channel blockers cardiovascular disease diuretics hypertension pharmacogenomics β-adrenoceptor blockers |
| status_str | publishedVersion |
| title | Genetic polymorphisms influencing antihypertensive drug responses |
| title_full | Genetic polymorphisms influencing antihypertensive drug responses |
| title_fullStr | Genetic polymorphisms influencing antihypertensive drug responses |
| title_full_unstemmed | Genetic polymorphisms influencing antihypertensive drug responses |
| title_short | Genetic polymorphisms influencing antihypertensive drug responses |
| title_sort | Genetic polymorphisms influencing antihypertensive drug responses |
| topic | Biological sciences Genetics Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences ACE inhibitors angiotensin receptor blockers calcium channel blockers cardiovascular disease diuretics hypertension pharmacogenomics β-adrenoceptor blockers |