Inflammatory Markers and COVID-19 Disease Progression
<h3>Background</h3> <p>The COVID-19 pandemic has resulted in a global humanitarian crisis. Despite ongoing research, transmission risks and many disease characteristics remain unclear. Most patients have displayed elevated levels of certain inflammatory markers, which we sought to...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| _version_ | 1864513557956132864 |
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| author | Santosh Kumar Sidhwani (16488557) |
| author2 | Talat Mirza (16319197) Ambrina Khatoon (16319200) Fouzia Shaikh (16319203) Rizma Khan (16319206) Omer Ahmed Shaikh (16488559) Abdulqadir J. Nashwan (16328993) |
| author2_role | author author author author author author |
| author_facet | Santosh Kumar Sidhwani (16488557) Talat Mirza (16319197) Ambrina Khatoon (16319200) Fouzia Shaikh (16319203) Rizma Khan (16319206) Omer Ahmed Shaikh (16488559) Abdulqadir J. Nashwan (16328993) |
| author_role | author |
| dc.creator.none.fl_str_mv | Santosh Kumar Sidhwani (16488557) Talat Mirza (16319197) Ambrina Khatoon (16319200) Fouzia Shaikh (16319203) Rizma Khan (16319206) Omer Ahmed Shaikh (16488559) Abdulqadir J. Nashwan (16328993) |
| dc.date.none.fl_str_mv | 2023-09-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jiph.2023.06.018 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inflammatory_Markers_and_COVID-19_Disease_Progression/23622588 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 CRP LDH Inflammatory Markers Pandemic |
| dc.title.none.fl_str_mv | Inflammatory Markers and COVID-19 Disease Progression |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3> <p>The COVID-19 pandemic has resulted in a global humanitarian crisis. Despite ongoing research, transmission risks and many disease characteristics remain unclear. Most patients have displayed elevated levels of certain inflammatory markers, which we sought to investigate further in relation to disease severity. The aim of this study was to examine the correlation between inflammatory markers and the severity of COVID-19 among patients.</p> <h3>Methods</h3> <p>We conducted a cross-sectional study from April to September 2020, involving 143 COVID-19 PCR-positive patients from Ziauddin Hospital. Electronic patient records provided data on demographics, clinical status, and laboratory results.</p> <h3>Results</h3> <p>The majority of PCR-positive patients were elderly males with comorbidities such as diabetes and hypertension. Almost all patients exhibited increased levels of various inflammatory markers, with procalcitonin (97.2%) being the most common. Statistically significant differences were observed in the levels of TLC (p=0.005), CRP (p=0.001), LDH (p=0.001), Ferritin (p=0.001), D-dimer (p=0.001), and procalcitonin (p=0.028), in relation to COVID-19 severity.</p> <h3>Conclusions</h3> <p>The data suggest a significant association between levels of inflammatory markers and COVID-19 severity. All markers, except procalcitonin, demonstrated a significant correlation with disease severity. These results could enhance our understanding of COVID-19 pathogenesis and help predict and manage severe cases.</p> <h2>Other Information</h2> <p>Published in: Journal of Infection and Public Health<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.1016/j.jiph.2023.06.018" target="_blank">https://doi.org/10.1016/j.jiph.2023.06.018</a> </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5deb57f4a32369569a1c4106a4b746b8 |
| identifier_str_mv | 10.1016/j.jiph.2023.06.018 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23622588 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inflammatory Markers and COVID-19 Disease ProgressionSantosh Kumar Sidhwani (16488557)Talat Mirza (16319197)Ambrina Khatoon (16319200)Fouzia Shaikh (16319203)Rizma Khan (16319206)Omer Ahmed Shaikh (16488559)Abdulqadir J. Nashwan (16328993)Biomedical and clinical sciencesClinical sciencesHealth sciencesPublic healthCOVID-19CRPLDHInflammatoryMarkersPandemic<h3>Background</h3> <p>The COVID-19 pandemic has resulted in a global humanitarian crisis. Despite ongoing research, transmission risks and many disease characteristics remain unclear. Most patients have displayed elevated levels of certain inflammatory markers, which we sought to investigate further in relation to disease severity. The aim of this study was to examine the correlation between inflammatory markers and the severity of COVID-19 among patients.</p> <h3>Methods</h3> <p>We conducted a cross-sectional study from April to September 2020, involving 143 COVID-19 PCR-positive patients from Ziauddin Hospital. Electronic patient records provided data on demographics, clinical status, and laboratory results.</p> <h3>Results</h3> <p>The majority of PCR-positive patients were elderly males with comorbidities such as diabetes and hypertension. Almost all patients exhibited increased levels of various inflammatory markers, with procalcitonin (97.2%) being the most common. Statistically significant differences were observed in the levels of TLC (p=0.005), CRP (p=0.001), LDH (p=0.001), Ferritin (p=0.001), D-dimer (p=0.001), and procalcitonin (p=0.028), in relation to COVID-19 severity.</p> <h3>Conclusions</h3> <p>The data suggest a significant association between levels of inflammatory markers and COVID-19 severity. All markers, except procalcitonin, demonstrated a significant correlation with disease severity. These results could enhance our understanding of COVID-19 pathogenesis and help predict and manage severe cases.</p> <h2>Other Information</h2> <p>Published in: Journal of Infection and Public Health<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.1016/j.jiph.2023.06.018" target="_blank">https://doi.org/10.1016/j.jiph.2023.06.018</a> </p>2023-09-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jiph.2023.06.018https://figshare.com/articles/journal_contribution/Inflammatory_Markers_and_COVID-19_Disease_Progression/23622588CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/236225882023-09-01T00:00:00Z |
| spellingShingle | Inflammatory Markers and COVID-19 Disease Progression Santosh Kumar Sidhwani (16488557) Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 CRP LDH Inflammatory Markers Pandemic |
| status_str | publishedVersion |
| title | Inflammatory Markers and COVID-19 Disease Progression |
| title_full | Inflammatory Markers and COVID-19 Disease Progression |
| title_fullStr | Inflammatory Markers and COVID-19 Disease Progression |
| title_full_unstemmed | Inflammatory Markers and COVID-19 Disease Progression |
| title_short | Inflammatory Markers and COVID-19 Disease Progression |
| title_sort | Inflammatory Markers and COVID-19 Disease Progression |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Public health COVID-19 CRP LDH Inflammatory Markers Pandemic |