Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers
<p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and reg...
محفوظ في:
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| مؤلفون آخرون: | , , |
| منشور في: |
2020
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| _version_ | 1864513512408088576 |
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| author | Olfa Khalifa (10914452) |
| author2 | Khaoula Errafii (10914446) Nayla S. Al-Akl (14570834) Abdelilah Arredouani (14070786) |
| author2_role | author author author |
| author_facet | Olfa Khalifa (10914452) Khaoula Errafii (10914446) Nayla S. Al-Akl (14570834) Abdelilah Arredouani (14070786) |
| author_role | author |
| dc.creator.none.fl_str_mv | Olfa Khalifa (10914452) Khaoula Errafii (10914446) Nayla S. Al-Akl (14570834) Abdelilah Arredouani (14070786) |
| dc.date.none.fl_str_mv | 2020-08-27T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2020/8822859 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Noncoding_RNAs_in_Nonalcoholic_Fatty_Liver_Disease_Potential_Diagnosis_and_Prognosis_Biomarkers/22014815 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Biochemistry (medical) Clinical Biochemistry Genetics Molecular Biology General Medicine |
| dc.title.none.fl_str_mv | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and regulatory pathways. The molecular mechanisms underlying the nonalcoholic steatosis formation are poorly understood, and little information is available on the pathways that are responsible for the progressive hepatocellular damage that follows lipid accumulation. Recently, much research has focused on the identification of the epigenetic modifications that contribute to NAFLD pathogenesis. Noncoding RNAs (ncRNAs) are one of such epigenetic factors that could be implicated in the NAFLD development and progression. In this review, we summarize the current knowledge of the genetic and epigenetic factors potentially underlying the disease. Particular emphasis will be put on the contribution of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) to the pathophysiology of NAFLD as well as their potential use as therapeutic targets or as markers for the prediction and the progression of the disease. </p> <h2>Other information </h2> <p>Published in: Disease Markers<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2020/8822859" target="_blank">http://dx.doi.org/10.1155/2020/8822859</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5e0e4de8a597fc2187a65cd9212c0d5b |
| identifier_str_mv | 10.1155/2020/8822859 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22014815 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis BiomarkersOlfa Khalifa (10914452)Khaoula Errafii (10914446)Nayla S. Al-Akl (14570834)Abdelilah Arredouani (14070786)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesBiochemistry (medical)Clinical BiochemistryGeneticsMolecular BiologyGeneral Medicine<p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). It is increasingly becoming evident that NAFLD is a disease affecting numerous extrahepatic vital organs and regulatory pathways. The molecular mechanisms underlying the nonalcoholic steatosis formation are poorly understood, and little information is available on the pathways that are responsible for the progressive hepatocellular damage that follows lipid accumulation. Recently, much research has focused on the identification of the epigenetic modifications that contribute to NAFLD pathogenesis. Noncoding RNAs (ncRNAs) are one of such epigenetic factors that could be implicated in the NAFLD development and progression. In this review, we summarize the current knowledge of the genetic and epigenetic factors potentially underlying the disease. Particular emphasis will be put on the contribution of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) to the pathophysiology of NAFLD as well as their potential use as therapeutic targets or as markers for the prediction and the progression of the disease. </p> <h2>Other information </h2> <p>Published in: Disease Markers<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2020/8822859" target="_blank">http://dx.doi.org/10.1155/2020/8822859</a></p>2020-08-27T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2020/8822859https://figshare.com/articles/journal_contribution/Noncoding_RNAs_in_Nonalcoholic_Fatty_Liver_Disease_Potential_Diagnosis_and_Prognosis_Biomarkers/22014815CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/220148152020-08-27T06:00:00Z |
| spellingShingle | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers Olfa Khalifa (10914452) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Biochemistry (medical) Clinical Biochemistry Genetics Molecular Biology General Medicine |
| status_str | publishedVersion |
| title | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| title_full | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| title_fullStr | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| title_full_unstemmed | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| title_short | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| title_sort | Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Biochemistry (medical) Clinical Biochemistry Genetics Molecular Biology General Medicine |