Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin
<p dir="ltr">Cutaneous T‐cell lymphomas (CTC) are a heterogeneous group of T‐cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in orchestrating the uncontrolled growth and proliferati...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2024
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| _version_ | 1864513543071596544 |
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| author | Abdul Q. Khan (14153247) |
| author2 | Maha Victor Agha (16932492) Fareed Ahmad (134672) Rasheeda Anver (17346850) Khalid Sultan A. M. Sheikhan (21841388) Jericha Mateo (21841391) Majid Alam (14158959) Joerg Buddenkotte (6293584) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| author2_role | author author author author author author author author author |
| author_facet | Abdul Q. Khan (14153247) Maha Victor Agha (16932492) Fareed Ahmad (134672) Rasheeda Anver (17346850) Khalid Sultan A. M. Sheikhan (21841388) Jericha Mateo (21841391) Majid Alam (14158959) Joerg Buddenkotte (6293584) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdul Q. Khan (14153247) Maha Victor Agha (16932492) Fareed Ahmad (134672) Rasheeda Anver (17346850) Khalid Sultan A. M. Sheikhan (21841388) Jericha Mateo (21841391) Majid Alam (14158959) Joerg Buddenkotte (6293584) Shahab Uddin (154400) Martin Steinhoff (5340194) |
| dc.date.none.fl_str_mv | 2024-06-30T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/cpr.13701 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolomics_analyses_reveal_the_crucial_role_of_ERK_in_regulating_metabolic_pathways_associated_with_the_proliferation_of_human_cutaneous_T_cell_lymphoma_cells_treated_with_Glabridin/29714918 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer biology Metabolic reprogramming Apoptosis Autophagy Necrosis Drug sensitization Bortezomib Metabolomics |
| dc.title.none.fl_str_mv | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cutaneous T‐cell lymphomas (CTC) are a heterogeneous group of T‐cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in orchestrating the uncontrolled growth and proliferation of cancer cells. Importantly, deregulated signalling plays a significant role in metabolic reprogramming. Considering the crucial role of metabolic reprogramming in cancer‐cell growth and proliferation, target identification and the development of novel and multi‐targeting agents are imperative. The present study explores the underlying mechanisms and metabolic signalling pathways associated with Glabridin mediated anti‐cancer actions in CTCL. Our results show that Glabridin significantly inhibits the growth of CTCL cells through induction of programmed cell death (PCD) such as apoptosis, autophagy and necrosis. Interestingly, results further show that Glabridin induces PCD in CTCL cells by targeting MAPK signalling pathways, particularly the activation of ERK. Further, Glabridin also sensitized CTCL cells to the anti‐cancer drug, bortezomib. Importantly, LC–MS‐based metabolomics analyses further showed that Glabridin targeted multiple metabolites and metabolic pathways intricately involved in cancer cell growth and proliferation in an ERK‐dependent fashion. Overall, our findings revealed that Glabridin induces PCD and attenuates the expression of regulatory proteins and metabolites involved in orchestrating the uncontrolled proliferation of CTCL cells through ERK activation. Therefore, Glabridin possesses important features of an ideal anti‐cancer agent.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Proliferation<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/cpr.13701" target="_blank">https://dx.doi.org/10.1111/cpr.13701</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_5e10fc29680c70a40e9c277ff58fbe55 |
| identifier_str_mv | 10.1111/cpr.13701 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29714918 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with GlabridinAbdul Q. Khan (14153247)Maha Victor Agha (16932492)Fareed Ahmad (134672)Rasheeda Anver (17346850)Khalid Sultan A. M. Sheikhan (21841388)Jericha Mateo (21841391)Majid Alam (14158959)Joerg Buddenkotte (6293584)Shahab Uddin (154400)Martin Steinhoff (5340194)Biomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesisPharmacology and pharmaceutical sciencesCancer biologyMetabolic reprogrammingApoptosisAutophagyNecrosisDrug sensitizationBortezomibMetabolomics<p dir="ltr">Cutaneous T‐cell lymphomas (CTC) are a heterogeneous group of T‐cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in orchestrating the uncontrolled growth and proliferation of cancer cells. Importantly, deregulated signalling plays a significant role in metabolic reprogramming. Considering the crucial role of metabolic reprogramming in cancer‐cell growth and proliferation, target identification and the development of novel and multi‐targeting agents are imperative. The present study explores the underlying mechanisms and metabolic signalling pathways associated with Glabridin mediated anti‐cancer actions in CTCL. Our results show that Glabridin significantly inhibits the growth of CTCL cells through induction of programmed cell death (PCD) such as apoptosis, autophagy and necrosis. Interestingly, results further show that Glabridin induces PCD in CTCL cells by targeting MAPK signalling pathways, particularly the activation of ERK. Further, Glabridin also sensitized CTCL cells to the anti‐cancer drug, bortezomib. Importantly, LC–MS‐based metabolomics analyses further showed that Glabridin targeted multiple metabolites and metabolic pathways intricately involved in cancer cell growth and proliferation in an ERK‐dependent fashion. Overall, our findings revealed that Glabridin induces PCD and attenuates the expression of regulatory proteins and metabolites involved in orchestrating the uncontrolled proliferation of CTCL cells through ERK activation. Therefore, Glabridin possesses important features of an ideal anti‐cancer agent.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Proliferation<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/cpr.13701" target="_blank">https://dx.doi.org/10.1111/cpr.13701</a></p>2024-06-30T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/cpr.13701https://figshare.com/articles/journal_contribution/Metabolomics_analyses_reveal_the_crucial_role_of_ERK_in_regulating_metabolic_pathways_associated_with_the_proliferation_of_human_cutaneous_T_cell_lymphoma_cells_treated_with_Glabridin/29714918CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297149182024-06-30T09:00:00Z |
| spellingShingle | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin Abdul Q. Khan (14153247) Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer biology Metabolic reprogramming Apoptosis Autophagy Necrosis Drug sensitization Bortezomib Metabolomics |
| status_str | publishedVersion |
| title | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| title_full | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| title_fullStr | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| title_full_unstemmed | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| title_short | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| title_sort | Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer biology Metabolic reprogramming Apoptosis Autophagy Necrosis Drug sensitization Bortezomib Metabolomics |