Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention
<p dir="ltr">Tizanidine withdrawal is a rare and complex phenomenon characterized by a surge in adrenergic activity upon abrupt discontinuation of the drug. We present a unique case of a 41-year-old male with multiple comorbidities who self-administered an exceptionally high daily do...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2024
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| _version_ | 1864513545517924352 |
|---|---|
| author | Marah Omer (21633203) |
| author2 | Yavuz Yigit (17788490) Baha Hamdi Alkahlout (20482667) Eslam Hussein Mohamed (20482664) Sulafa Khalil (17136004) Aftab Mohammad Azad (17337679) |
| author2_role | author author author author author |
| author_facet | Marah Omer (21633203) Yavuz Yigit (17788490) Baha Hamdi Alkahlout (20482667) Eslam Hussein Mohamed (20482664) Sulafa Khalil (17136004) Aftab Mohammad Azad (17337679) |
| author_role | author |
| dc.creator.none.fl_str_mv | Marah Omer (21633203) Yavuz Yigit (17788490) Baha Hamdi Alkahlout (20482667) Eslam Hussein Mohamed (20482664) Sulafa Khalil (17136004) Aftab Mohammad Azad (17337679) |
| dc.date.none.fl_str_mv | 2024-02-16T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1093/omcr/omae005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Maximal_Tizanidine_withdrawal_managed_with_dexmedetomidine_a_vital_intervention/29445746 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Tizanidine withdrawal Adrenergic surge Rebound hypertension Tachycardia Neuropsychiatric symptoms Muscle movements |
| dc.title.none.fl_str_mv | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Tizanidine withdrawal is a rare and complex phenomenon characterized by a surge in adrenergic activity upon abrupt discontinuation of the drug. We present a unique case of a 41-year-old male with multiple comorbidities who self-administered an exceptionally high daily dose of Tizanidine, leading to severe withdrawal symptoms. This case report highlights the challenges in managing such cases. The patient, with a history of myofascial pain syndrome, hypertension, anxiety, and depression, experienced distressing symptoms, including tachycardia, rebound hypertension, neuropsychiatric manifestations, and involuntary muscle movements. Unlike previous cases, our patient required the addition of dexmedetomidine in conjunction with benzodiazepines for symptom management. Reintroduction of Tizanidine, carefully controlled and tapered, led to stabilization of hemodynamics and cessation of involuntary movements. This case underscores the importance of individualized treatment and vigilant monitoring when dealing with Tizanidine withdrawal, particularly at elevated daily doses.</p><h2>Other Information</h2><p dir="ltr">Published in: Oxford Medical Case Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/omcr/omae005" target="_blank">https://dx.doi.org/10.1093/omcr/omae005</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_602dad7ee6eef4acf671e90d6f60aad6 |
| identifier_str_mv | 10.1093/omcr/omae005 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29445746 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital interventionMarah Omer (21633203)Yavuz Yigit (17788490)Baha Hamdi Alkahlout (20482667)Eslam Hussein Mohamed (20482664)Sulafa Khalil (17136004)Aftab Mohammad Azad (17337679)Biomedical and clinical sciencesClinical sciencesNeurosciencesPharmacology and pharmaceutical sciencesTizanidine withdrawalAdrenergic surgeRebound hypertensionTachycardiaNeuropsychiatric symptomsMuscle movements<p dir="ltr">Tizanidine withdrawal is a rare and complex phenomenon characterized by a surge in adrenergic activity upon abrupt discontinuation of the drug. We present a unique case of a 41-year-old male with multiple comorbidities who self-administered an exceptionally high daily dose of Tizanidine, leading to severe withdrawal symptoms. This case report highlights the challenges in managing such cases. The patient, with a history of myofascial pain syndrome, hypertension, anxiety, and depression, experienced distressing symptoms, including tachycardia, rebound hypertension, neuropsychiatric manifestations, and involuntary muscle movements. Unlike previous cases, our patient required the addition of dexmedetomidine in conjunction with benzodiazepines for symptom management. Reintroduction of Tizanidine, carefully controlled and tapered, led to stabilization of hemodynamics and cessation of involuntary movements. This case underscores the importance of individualized treatment and vigilant monitoring when dealing with Tizanidine withdrawal, particularly at elevated daily doses.</p><h2>Other Information</h2><p dir="ltr">Published in: Oxford Medical Case Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/omcr/omae005" target="_blank">https://dx.doi.org/10.1093/omcr/omae005</a></p>2024-02-16T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1093/omcr/omae005https://figshare.com/articles/journal_contribution/Maximal_Tizanidine_withdrawal_managed_with_dexmedetomidine_a_vital_intervention/29445746CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294457462024-02-16T09:00:00Z |
| spellingShingle | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention Marah Omer (21633203) Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Tizanidine withdrawal Adrenergic surge Rebound hypertension Tachycardia Neuropsychiatric symptoms Muscle movements |
| status_str | publishedVersion |
| title | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| title_full | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| title_fullStr | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| title_full_unstemmed | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| title_short | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| title_sort | Maximal Tizanidine withdrawal managed with dexmedetomidine: a vital intervention |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Pharmacology and pharmaceutical sciences Tizanidine withdrawal Adrenergic surge Rebound hypertension Tachycardia Neuropsychiatric symptoms Muscle movements |