Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study
<p dir="ltr">Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of lower urinary tract symptoms (LUTS) and related symp...
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2023
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| _version_ | 1864513527980490752 |
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| author | Aksam Yassin (14779204) |
| author2 | Daniel Kelly (7412216) Joanne Nettleship (29762) Raidh Talib (14779198) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Bassam Albaba (17787569) |
| author2_role | author author author author author author |
| author_facet | Aksam Yassin (14779204) Daniel Kelly (7412216) Joanne Nettleship (29762) Raidh Talib (14779198) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Bassam Albaba (17787569) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aksam Yassin (14779204) Daniel Kelly (7412216) Joanne Nettleship (29762) Raidh Talib (14779198) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) Bassam Albaba (17787569) |
| dc.date.none.fl_str_mv | 2023-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1080/13685538.2023.2220567 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Testosterone_treatment_and_change_of_categories_of_the_International_prostate_symptom_score_IPSS_in_hypogonadal_patients_12_years_prospective_controlled_registry_study/25160186 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism LUTS IPSS testosterone treatment prostate cancer |
| dc.title.none.fl_str_mv | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of lower urinary tract symptoms (LUTS) and related symptoms in hypogonadal men. Testosterone therapy (TTh) has previously shown potential in improving total IPSS in men with hypogonadism. However, concerns regarding the effects of urinary function following TTh often prevent treatment in hypogonadal men. To explore this further, two population-based single-center, prospective, cumulative registry studies were combined to contribute to a total population of 1176 men with symptoms of hypogonadism. The total population was separated into a TTh group receiving testosterone undecanoate (TU) for up to 12 years and a control group that did not receive treatment. IPSS was recorded at both baseline and at final recorded visit for each patient. Long-term TTh with TU in hypogonadal men resulted in significant improvements in IPSS categories, even in patients with severe symptoms at baseline. In the control group, untreated hypogonadal men experienced a worsening of IPSS categories. These data indicate that TTh improves LUTS in men with hypogonadism and suggest that previous concerns regarding urinary function may have been overstated.</p><h2>Other Information</h2><p dir="ltr">Published in: The Aging Male<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/13685538.2023.2220567" target="_blank">https://dx.doi.org/10.1080/13685538.2023.2220567</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_603ef710732fcfcfa11db2d96a8c10ec |
| identifier_str_mv | 10.1080/13685538.2023.2220567 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25160186 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry studyAksam Yassin (14779204)Daniel Kelly (7412216)Joanne Nettleship (29762)Raidh Talib (14779198)Raed M. Al-Zoubi (2037490)Omar M. Aboumarzouk (14779240)Bassam Albaba (17787569)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisHypogonadismLUTSIPSStestosterone treatmentprostate cancer<p dir="ltr">Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of lower urinary tract symptoms (LUTS) and related symptoms in hypogonadal men. Testosterone therapy (TTh) has previously shown potential in improving total IPSS in men with hypogonadism. However, concerns regarding the effects of urinary function following TTh often prevent treatment in hypogonadal men. To explore this further, two population-based single-center, prospective, cumulative registry studies were combined to contribute to a total population of 1176 men with symptoms of hypogonadism. The total population was separated into a TTh group receiving testosterone undecanoate (TU) for up to 12 years and a control group that did not receive treatment. IPSS was recorded at both baseline and at final recorded visit for each patient. Long-term TTh with TU in hypogonadal men resulted in significant improvements in IPSS categories, even in patients with severe symptoms at baseline. In the control group, untreated hypogonadal men experienced a worsening of IPSS categories. These data indicate that TTh improves LUTS in men with hypogonadism and suggest that previous concerns regarding urinary function may have been overstated.</p><h2>Other Information</h2><p dir="ltr">Published in: The Aging Male<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/13685538.2023.2220567" target="_blank">https://dx.doi.org/10.1080/13685538.2023.2220567</a></p>2023-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1080/13685538.2023.2220567https://figshare.com/articles/journal_contribution/Testosterone_treatment_and_change_of_categories_of_the_International_prostate_symptom_score_IPSS_in_hypogonadal_patients_12_years_prospective_controlled_registry_study/25160186CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/251601862023-06-01T00:00:00Z |
| spellingShingle | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study Aksam Yassin (14779204) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism LUTS IPSS testosterone treatment prostate cancer |
| status_str | publishedVersion |
| title | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| title_full | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| title_fullStr | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| title_full_unstemmed | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| title_short | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| title_sort | Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Hypogonadism LUTS IPSS testosterone treatment prostate cancer |