The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials
<h3>Aim/hypothesis</h3><p dir="ltr">The globally escalating diabetes epidemic is responsible for significant morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated for their potential to restore metabolic and floral homeostasis in type 2 diab...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513538519728128 |
|---|---|
| author | Pradipta Paul (12628162) |
| author2 | Ridhima Kaul (12485902) Manale Harfouche (4557211) Maryam Arabi (3927509) Yousef Al-Najjar (14147835) Aparajita Sarkar (3016749) Reya Saliba (12628168) Ali Chaari (827168) |
| author2_role | author author author author author author author |
| author_facet | Pradipta Paul (12628162) Ridhima Kaul (12485902) Manale Harfouche (4557211) Maryam Arabi (3927509) Yousef Al-Najjar (14147835) Aparajita Sarkar (3016749) Reya Saliba (12628168) Ali Chaari (827168) |
| author_role | author |
| dc.creator.none.fl_str_mv | Pradipta Paul (12628162) Ridhima Kaul (12485902) Manale Harfouche (4557211) Maryam Arabi (3927509) Yousef Al-Najjar (14147835) Aparajita Sarkar (3016749) Reya Saliba (12628168) Ali Chaari (827168) |
| dc.date.none.fl_str_mv | 2022-11-01T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.phrs.2022.106520 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_effect_of_microbiome-modulating_probiotics_prebiotics_and_synbiotics_on_glucose_homeostasis_in_type_2_diabetes_A_systematic_review_meta-analysis_and_meta-regression_of_clinical_trials/24516499 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Nutrition and dietetics Mathematical sciences Statistics Gut flora Gut microbiome Glycemia Insulinemia Nutraceutical Short-chain fatty acids Inflammation Insulin resistan ceInsulin sensitivity Hyperglycemia |
| dc.title.none.fl_str_mv | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aim/hypothesis</h3><p dir="ltr">The globally escalating diabetes epidemic is responsible for significant morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated for their potential to restore metabolic and floral homeostasis in type 2 diabetic patients.</p><h3>Methods</h3><p dir="ltr">A systematic review, meta-analyses and meta-regressions were conducted to investigate the effect of probiotics, prebiotics, and synbiotics on various biomarkers of glucose homeostasis based on a multi-database search of clinical trials published through April 10, 2022. Data was pooled using random effects meta-analyses and reported as mean differences with 95% confidence intervals (CIs), followed by univariate linear model meta-regression.</p><h3>Results</h3><p dir="ltr">Data from 68 trial comparisons across 58 studies (n = 3835) revealed that, compared to placebo/control group, administration of pro/pre/synbiotics was associated with statistically significant changes in fasting plasma glucose (−12.41 mg/dl [95% CI: −15.94; −8.88], p 0.0001), glycated hemoglobin (−0.38% [95% CI: −0.47; −0.30], p 0.0001), fasting insulin (−1.49 µU/mL [95% CI: −2.12; −0.86], p 0.0001), HOMA-IR (−0.69 [95% CI: −1.16; −0.23], p = 0.0031) and QUICKI (0.0148 [95% CI: 0.0052; 0.0244], p = 0.0025), but not C-peptide (−0.0144 ng/mL [95% CI: −0.2564; −0.2275], p = 0.9069). Age, baseline BMI, baseline biomarker value, pro/prebiotic dosage, trial duration, nutraceutical type, and recruitment region significantly affected the potential of pro/pre/synbiotics use as personalized diabetes adjunct therapy. Lastly, we discuss unexplained observations and directives for future trials, with the aim of maximizing our understanding of how microbiome-modulating nutraceuticals can treat various metabolic diseases.</p><h3>Conclusions</h3><p dir="ltr">Pro/pre/synbiotic supplementation improved glucose homeostasis in diabetic patients. Our results support their potential use as adjunct therapy for improving glycemia and insulinemia alongside pharmacological therapeutics.</p><h2>Other Information</h2><p dir="ltr">Published in: Pharmacological Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.phrs.2022.106520" target="_blank">https://dx.doi.org/10.1016/j.phrs.2022.106520</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_603f7fb9834f62c94a55420720caa817 |
| identifier_str_mv | 10.1016/j.phrs.2022.106520 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516499 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trialsPradipta Paul (12628162)Ridhima Kaul (12485902)Manale Harfouche (4557211)Maryam Arabi (3927509)Yousef Al-Najjar (14147835)Aparajita Sarkar (3016749)Reya Saliba (12628168)Ali Chaari (827168)Biomedical and clinical sciencesClinical sciencesNutrition and dieteticsMathematical sciencesStatisticsGut floraGut microbiomeGlycemiaInsulinemiaNutraceuticalShort-chain fatty acidsInflammationInsulin resistanceInsulin sensitivityHyperglycemia<h3>Aim/hypothesis</h3><p dir="ltr">The globally escalating diabetes epidemic is responsible for significant morbidity and mortality. Microbiome-modulating nutraceuticals have been investigated for their potential to restore metabolic and floral homeostasis in type 2 diabetic patients.</p><h3>Methods</h3><p dir="ltr">A systematic review, meta-analyses and meta-regressions were conducted to investigate the effect of probiotics, prebiotics, and synbiotics on various biomarkers of glucose homeostasis based on a multi-database search of clinical trials published through April 10, 2022. Data was pooled using random effects meta-analyses and reported as mean differences with 95% confidence intervals (CIs), followed by univariate linear model meta-regression.</p><h3>Results</h3><p dir="ltr">Data from 68 trial comparisons across 58 studies (n = 3835) revealed that, compared to placebo/control group, administration of pro/pre/synbiotics was associated with statistically significant changes in fasting plasma glucose (−12.41 mg/dl [95% CI: −15.94; −8.88], p 0.0001), glycated hemoglobin (−0.38% [95% CI: −0.47; −0.30], p 0.0001), fasting insulin (−1.49 µU/mL [95% CI: −2.12; −0.86], p 0.0001), HOMA-IR (−0.69 [95% CI: −1.16; −0.23], p = 0.0031) and QUICKI (0.0148 [95% CI: 0.0052; 0.0244], p = 0.0025), but not C-peptide (−0.0144 ng/mL [95% CI: −0.2564; −0.2275], p = 0.9069). Age, baseline BMI, baseline biomarker value, pro/prebiotic dosage, trial duration, nutraceutical type, and recruitment region significantly affected the potential of pro/pre/synbiotics use as personalized diabetes adjunct therapy. Lastly, we discuss unexplained observations and directives for future trials, with the aim of maximizing our understanding of how microbiome-modulating nutraceuticals can treat various metabolic diseases.</p><h3>Conclusions</h3><p dir="ltr">Pro/pre/synbiotic supplementation improved glucose homeostasis in diabetic patients. Our results support their potential use as adjunct therapy for improving glycemia and insulinemia alongside pharmacological therapeutics.</p><h2>Other Information</h2><p dir="ltr">Published in: Pharmacological Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.phrs.2022.106520" target="_blank">https://dx.doi.org/10.1016/j.phrs.2022.106520</a></p>2022-11-01T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.phrs.2022.106520https://figshare.com/articles/journal_contribution/The_effect_of_microbiome-modulating_probiotics_prebiotics_and_synbiotics_on_glucose_homeostasis_in_type_2_diabetes_A_systematic_review_meta-analysis_and_meta-regression_of_clinical_trials/24516499CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245164992022-11-01T21:00:00Z |
| spellingShingle | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials Pradipta Paul (12628162) Biomedical and clinical sciences Clinical sciences Nutrition and dietetics Mathematical sciences Statistics Gut flora Gut microbiome Glycemia Insulinemia Nutraceutical Short-chain fatty acids Inflammation Insulin resistan ceInsulin sensitivity Hyperglycemia |
| status_str | publishedVersion |
| title | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| title_full | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| title_fullStr | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| title_full_unstemmed | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| title_short | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| title_sort | The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials |
| topic | Biomedical and clinical sciences Clinical sciences Nutrition and dietetics Mathematical sciences Statistics Gut flora Gut microbiome Glycemia Insulinemia Nutraceutical Short-chain fatty acids Inflammation Insulin resistan ceInsulin sensitivity Hyperglycemia |