Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database

<p dir="ltr">Since its introduction in 2019, brolucizumab’s safety has been called into question due to numerous reports of IOI following intravitreal injections. In 2020, post-marketing data showed that there was a confirmed safety alarm of severe ocular adverse events such as retin...

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Main Author: Ibraheem M. Alkhawaldeh (17430888) (author)
Other Authors: Hashem Abu Serhan (16003271) (author)
Published: 2024
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author Ibraheem M. Alkhawaldeh (17430888)
author2 Hashem Abu Serhan (16003271)
author2_role author
author_facet Ibraheem M. Alkhawaldeh (17430888)
Hashem Abu Serhan (16003271)
author_role author
dc.creator.none.fl_str_mv Ibraheem M. Alkhawaldeh (17430888)
Hashem Abu Serhan (16003271)
dc.date.none.fl_str_mv 2024-04-24T09:00:00Z
dc.identifier.none.fl_str_mv 10.1038/s41433-024-03079-0
dc.relation.none.fl_str_mv https://figshare.com/articles/journal_contribution/Intraocular_Inflammation_with_faricimab_insights_from_Manufacturer_and_User_Facility_Device_Experience_MAUDE_database/29714969
dc.rights.none.fl_str_mv CC BY 4.0
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Biomedical and clinical sciences
Clinical sciences
Pharmacology and pharmaceutical sciences
Intraocular inflammation (IOI)
Retinal vasculitis
Retinal vascular occlusion
Intravitreal injection
Ocular adverse events
dc.title.none.fl_str_mv Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
dc.type.none.fl_str_mv Text
Journal contribution
info:eu-repo/semantics/publishedVersion
text
contribution to journal
description <p dir="ltr">Since its introduction in 2019, brolucizumab’s safety has been called into question due to numerous reports of IOI following intravitreal injections. In 2020, post-marketing data showed that there was a confirmed safety alarm of severe ocular adverse events such as retinal vasculitis, and retinal vascular occlusion that may lead to severe visual acuity loss. These events were reported at rates of 3.61 and 2.35 per 10,000 injections, respectively. New concerns have been raised by Thangamathesvaran et al. on intraocular inflammation (IOI) after intravitreal faricimab (Vabysmo). Therefore, investigating underlying risk factors for IOI development following faricimab would enhance our understanding of this safety concern and inform clinical decision-making.</p><h2>Other Information</h2><p dir="ltr">Published in: Eye<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41433-024-03079-0" target="_blank">https://dx.doi.org/10.1038/s41433-024-03079-0</a></p>
eu_rights_str_mv openAccess
id Manara2_6089bea9d69a56fa32578222123072fe
identifier_str_mv 10.1038/s41433-024-03079-0
network_acronym_str Manara2
network_name_str Manara2
oai_identifier_str oai:figshare.com:article/29714969
publishDate 2024
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rights_invalid_str_mv CC BY 4.0
spelling Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) databaseIbraheem M. Alkhawaldeh (17430888)Hashem Abu Serhan (16003271)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesIntraocular inflammation (IOI)Retinal vasculitisRetinal vascular occlusionIntravitreal injectionOcular adverse events<p dir="ltr">Since its introduction in 2019, brolucizumab’s safety has been called into question due to numerous reports of IOI following intravitreal injections. In 2020, post-marketing data showed that there was a confirmed safety alarm of severe ocular adverse events such as retinal vasculitis, and retinal vascular occlusion that may lead to severe visual acuity loss. These events were reported at rates of 3.61 and 2.35 per 10,000 injections, respectively. New concerns have been raised by Thangamathesvaran et al. on intraocular inflammation (IOI) after intravitreal faricimab (Vabysmo). Therefore, investigating underlying risk factors for IOI development following faricimab would enhance our understanding of this safety concern and inform clinical decision-making.</p><h2>Other Information</h2><p dir="ltr">Published in: Eye<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41433-024-03079-0" target="_blank">https://dx.doi.org/10.1038/s41433-024-03079-0</a></p>2024-04-24T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41433-024-03079-0https://figshare.com/articles/journal_contribution/Intraocular_Inflammation_with_faricimab_insights_from_Manufacturer_and_User_Facility_Device_Experience_MAUDE_database/29714969CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297149692024-04-24T09:00:00Z
spellingShingle Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
Ibraheem M. Alkhawaldeh (17430888)
Biomedical and clinical sciences
Clinical sciences
Pharmacology and pharmaceutical sciences
Intraocular inflammation (IOI)
Retinal vasculitis
Retinal vascular occlusion
Intravitreal injection
Ocular adverse events
status_str publishedVersion
title Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
title_full Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
title_fullStr Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
title_full_unstemmed Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
title_short Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
title_sort Intraocular Inflammation with faricimab: insights from Manufacturer and User Facility Device Experience (MAUDE) database
topic Biomedical and clinical sciences
Clinical sciences
Pharmacology and pharmaceutical sciences
Intraocular inflammation (IOI)
Retinal vasculitis
Retinal vascular occlusion
Intravitreal injection
Ocular adverse events