Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review
<p dir="ltr">The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying <u>enzymes</u>, signaling molecules...
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2025
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| _version_ | 1864513537648361472 |
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| author | Saïd Sif (13616740) |
| author2 | Majdi Al Alawneh (22391965) |
| author2_role | author |
| author_facet | Saïd Sif (13616740) Majdi Al Alawneh (22391965) |
| author_role | author |
| dc.creator.none.fl_str_mv | Saïd Sif (13616740) Majdi Al Alawneh (22391965) |
| dc.date.none.fl_str_mv | 2025-02-24T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.bbamcr.2025.119923 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Aberrant_miRNA_expression_and_protein_arginine_methyltransferase_5_PRMT5_in_cancer_A_review/30305953 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Protein arginine methyltransferase 5 WNT/β-CATENIN signaling PI3K/AKT signaling Tumor suppressor miRNA Glioblastoma |
| dc.title.none.fl_str_mv | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying <u>enzymes</u>, signaling molecules, and <u>miRNAs</u>. However, the interplay and crosstalk between some of these factors and the impact they have on tumorigenesis remains largely unexplored. In this review, we focus on type II <u>protein arginine methyltransferase 5</u> (PRMT5)-mediated epigenetic silencing and its regulatory <u>tumor suppressor miRNAs</u>, as well as the mechanisms by which circular PRMT5 <u>RNA</u> (circ-PRMT5) promotes cancer <u>cell proliferation</u> and survival.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2025.119923" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2025.119923</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6220a03c1701a7f9067baf3cdec9eccf |
| identifier_str_mv | 10.1016/j.bbamcr.2025.119923 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30305953 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A reviewSaïd Sif (13616740)Majdi Al Alawneh (22391965)Biological sciencesGeneticsBiomedical and clinical sciencesOncology and carcinogenesisProtein arginine methyltransferase 5WNT/β-CATENIN signalingPI3K/AKT signalingTumor suppressor miRNAGlioblastoma<p dir="ltr">The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying <u>enzymes</u>, signaling molecules, and <u>miRNAs</u>. However, the interplay and crosstalk between some of these factors and the impact they have on tumorigenesis remains largely unexplored. In this review, we focus on type II <u>protein arginine methyltransferase 5</u> (PRMT5)-mediated epigenetic silencing and its regulatory <u>tumor suppressor miRNAs</u>, as well as the mechanisms by which circular PRMT5 <u>RNA</u> (circ-PRMT5) promotes cancer <u>cell proliferation</u> and survival.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2025.119923" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2025.119923</a></p>2025-02-24T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.bbamcr.2025.119923https://figshare.com/articles/journal_contribution/Aberrant_miRNA_expression_and_protein_arginine_methyltransferase_5_PRMT5_in_cancer_A_review/30305953CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303059532025-02-24T12:00:00Z |
| spellingShingle | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review Saïd Sif (13616740) Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Protein arginine methyltransferase 5 WNT/β-CATENIN signaling PI3K/AKT signaling Tumor suppressor miRNA Glioblastoma |
| status_str | publishedVersion |
| title | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| title_full | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| title_fullStr | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| title_full_unstemmed | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| title_short | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| title_sort | Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review |
| topic | Biological sciences Genetics Biomedical and clinical sciences Oncology and carcinogenesis Protein arginine methyltransferase 5 WNT/β-CATENIN signaling PI3K/AKT signaling Tumor suppressor miRNA Glioblastoma |