Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study
<h2>Background</h2> <p>In previous studies, COVID-19 complications were reported to be associated with periodontitis. Accordingly, this study was designed to test the hypothesis that a history of periodontal therapy could be associated with lower risk of COVID-19 complications.<...
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2022
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| _version_ | 1864513567968985088 |
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| author | Khalid N. Said (14150715) |
| author2 | Ahmed M. Al-Momani (14150718) Jassim A. Almaseeh (14150721) Nadya Marouf (14150724) Amer Shatta (14150727) Jassim Al-Abdulla (14150730) Sahar Alaji (14150733) Hanin Daas (14150736) Shailaja S. Tharupeedikayil (14150739) Venkateswara Rao Chinta (14150742) Ali Ait Hssain (11264358) Mohammad Abusamak (10712848) Shiraz Salih (14150745) Noha Barhom (14150748) Wenji Cai (14150751) Mariano Sanz (4282618) Faleh Tamimi (2867255) |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Khalid N. Said (14150715) Ahmed M. Al-Momani (14150718) Jassim A. Almaseeh (14150721) Nadya Marouf (14150724) Amer Shatta (14150727) Jassim Al-Abdulla (14150730) Sahar Alaji (14150733) Hanin Daas (14150736) Shailaja S. Tharupeedikayil (14150739) Venkateswara Rao Chinta (14150742) Ali Ait Hssain (11264358) Mohammad Abusamak (10712848) Shiraz Salih (14150745) Noha Barhom (14150748) Wenji Cai (14150751) Mariano Sanz (4282618) Faleh Tamimi (2867255) |
| author_role | author |
| dc.creator.none.fl_str_mv | Khalid N. Said (14150715) Ahmed M. Al-Momani (14150718) Jassim A. Almaseeh (14150721) Nadya Marouf (14150724) Amer Shatta (14150727) Jassim Al-Abdulla (14150730) Sahar Alaji (14150733) Hanin Daas (14150736) Shailaja S. Tharupeedikayil (14150739) Venkateswara Rao Chinta (14150742) Ali Ait Hssain (11264358) Mohammad Abusamak (10712848) Shiraz Salih (14150745) Noha Barhom (14150748) Wenji Cai (14150751) Mariano Sanz (4282618) Faleh Tamimi (2867255) |
| dc.date.none.fl_str_mv | 2022-11-22T21:12:37Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00784-022-04631-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Association_of_periodontal_therapy_with_inflammatory_biomarkers_and_complications_in_COVID-19_patients_a_case_control_study/21597117 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Dentistry General Dentistry |
| dc.title.none.fl_str_mv | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Background</h2> <p>In previous studies, COVID-19 complications were reported to be associated with periodontitis. Accordingly, this study was designed to test the hypothesis that a history of periodontal therapy could be associated with lower risk of COVID-19 complications.</p> <h2>Methods</h2> <p>A case–control study was performed using the medical health records of COVID-19 patients in the State of Qatar between March 2020 and February 2021 and dental records between January 2017 and December 2021. Cases were defined as COVID-19 patients who suffered complications (death, ICU admissions and/or mechanical ventilation); controls were COVID-19 patients who recovered without major complications. Associations between a history of periodontal therapy and COVID-19 complications were analysed using logistic regression models adjusted for demographic and medical factors. Blood parameters were compared using Kruskal–Wallis test.</p> <h2>Results</h2> <p>In total, 1,325 patients were included. Adjusted odds ratio (AOR) analysis revealed that non-treated periodontitis was associated with significant risk of need for mechanical ventilation (AOR = 3.91, 95% CI 1.21–12.57, p = 0.022) compared to periodontally healthy patients, while treated periodontitis was not (AOR = 1.28, 95% CI 0.25–6.58, p = 0.768). Blood analyses revealed that periodontitis patients with a history of periodontal therapy had significantly lower levels of D-dimer and Ferritin than non-treated periodontitis patients.</p> <h2>Conclusion</h2> <p>Among COVID-19 patients with periodontal bone loss, only those that have not received periodontal therapy had higher risk of need for assisted ventilation. COVID-19 patients with a history of periodontal therapy were associated with significantly lower D-dimer levels than those without recent records of periodontal therapy.</p> <h2>Clinical relevance</h2> <p>The fact that patients with treated periodontitis were less likely to suffer COVID-19 complications than non-treated ones further strengthen the hypothesis linking periodontitis to COVID-19 complications and suggests that managing periodontitis could help reduce the risk for COVID-19 complications, although future research is needed to verify this. </p><h2>Other Information</h2> <p> Published in: Clinical Oral Investigations<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00784-022-04631-6" target="_blank">http://dx.doi.org/10.1007/s00784-022-04631-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6224583d88f23057e0b39ef54275fbf3 |
| identifier_str_mv | 10.1007/s00784-022-04631-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597117 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control studyKhalid N. Said (14150715)Ahmed M. Al-Momani (14150718)Jassim A. Almaseeh (14150721)Nadya Marouf (14150724)Amer Shatta (14150727)Jassim Al-Abdulla (14150730)Sahar Alaji (14150733)Hanin Daas (14150736)Shailaja S. Tharupeedikayil (14150739)Venkateswara Rao Chinta (14150742)Ali Ait Hssain (11264358)Mohammad Abusamak (10712848)Shiraz Salih (14150745)Noha Barhom (14150748)Wenji Cai (14150751)Mariano Sanz (4282618)Faleh Tamimi (2867255)DentistryGeneral Dentistry<h2>Background</h2> <p>In previous studies, COVID-19 complications were reported to be associated with periodontitis. Accordingly, this study was designed to test the hypothesis that a history of periodontal therapy could be associated with lower risk of COVID-19 complications.</p> <h2>Methods</h2> <p>A case–control study was performed using the medical health records of COVID-19 patients in the State of Qatar between March 2020 and February 2021 and dental records between January 2017 and December 2021. Cases were defined as COVID-19 patients who suffered complications (death, ICU admissions and/or mechanical ventilation); controls were COVID-19 patients who recovered without major complications. Associations between a history of periodontal therapy and COVID-19 complications were analysed using logistic regression models adjusted for demographic and medical factors. Blood parameters were compared using Kruskal–Wallis test.</p> <h2>Results</h2> <p>In total, 1,325 patients were included. Adjusted odds ratio (AOR) analysis revealed that non-treated periodontitis was associated with significant risk of need for mechanical ventilation (AOR = 3.91, 95% CI 1.21–12.57, p = 0.022) compared to periodontally healthy patients, while treated periodontitis was not (AOR = 1.28, 95% CI 0.25–6.58, p = 0.768). Blood analyses revealed that periodontitis patients with a history of periodontal therapy had significantly lower levels of D-dimer and Ferritin than non-treated periodontitis patients.</p> <h2>Conclusion</h2> <p>Among COVID-19 patients with periodontal bone loss, only those that have not received periodontal therapy had higher risk of need for assisted ventilation. COVID-19 patients with a history of periodontal therapy were associated with significantly lower D-dimer levels than those without recent records of periodontal therapy.</p> <h2>Clinical relevance</h2> <p>The fact that patients with treated periodontitis were less likely to suffer COVID-19 complications than non-treated ones further strengthen the hypothesis linking periodontitis to COVID-19 complications and suggests that managing periodontitis could help reduce the risk for COVID-19 complications, although future research is needed to verify this. </p><h2>Other Information</h2> <p> Published in: Clinical Oral Investigations<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00784-022-04631-6" target="_blank">http://dx.doi.org/10.1007/s00784-022-04631-6</a></p>2022-11-22T21:12:37ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00784-022-04631-6https://figshare.com/articles/journal_contribution/Association_of_periodontal_therapy_with_inflammatory_biomarkers_and_complications_in_COVID-19_patients_a_case_control_study/21597117CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215971172022-11-22T21:12:37Z |
| spellingShingle | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study Khalid N. Said (14150715) Dentistry General Dentistry |
| status_str | publishedVersion |
| title | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| title_full | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| title_fullStr | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| title_full_unstemmed | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| title_short | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| title_sort | Association of periodontal therapy, with inflammatory biomarkers and complications in COVID-19 patients: a case control study |
| topic | Dentistry General Dentistry |