New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications
<p>Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of a...
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2018
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| _version_ | 1864513510843613184 |
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| author | Hesham Ismail (12840683) |
| author2 | Somayeh Zamani (8408628) Mohamed Elrayess (3522407) Wael Kafienah (8597088) Husam Younes (18808321) |
| author2_role | author author author author |
| author_facet | Hesham Ismail (12840683) Somayeh Zamani (8408628) Mohamed Elrayess (3522407) Wael Kafienah (8597088) Husam Younes (18808321) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hesham Ismail (12840683) Somayeh Zamani (8408628) Mohamed Elrayess (3522407) Wael Kafienah (8597088) Husam Younes (18808321) |
| dc.date.none.fl_str_mv | 2018-04-19T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/polym10040455 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/New_Three-Dimensional_Poly_decanediol-co-tricarballylate_Elastomeric_Fibrous_Mesh_Fabricated_by_Photoreactive_Electrospinning_for_Cardiac_Tissue_Engineering_Applications/26019496 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Biomedical engineering Materials engineering poly(diol-tricarballylate) reactive electrospinning particulate leaching photo-crosslinking cardiac tissue engineering biocompatibility |
| dc.title.none.fl_str_mv | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-co-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications. </p> <p><br></p> <h2>Other Information</h2> <p>Published in: Polymers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://dx.doi.org/10.3390/polym10040455" target="_blank">https://dx.doi.org/10.3390/polym10040455</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_62b1f7bef4ddf08151706a2fb9138be9 |
| identifier_str_mv | 10.3390/polym10040455 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26019496 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering ApplicationsHesham Ismail (12840683)Somayeh Zamani (8408628)Mohamed Elrayess (3522407)Wael Kafienah (8597088)Husam Younes (18808321)EngineeringBiomedical engineeringMaterials engineeringpoly(diol-tricarballylate)reactive electrospinningparticulate leachingphoto-crosslinkingcardiac tissue engineeringbiocompatibility<p>Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-co-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications. </p> <p><br></p> <h2>Other Information</h2> <p>Published in: Polymers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://dx.doi.org/10.3390/polym10040455" target="_blank">https://dx.doi.org/10.3390/polym10040455</a></p>2018-04-19T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/polym10040455https://figshare.com/articles/journal_contribution/New_Three-Dimensional_Poly_decanediol-co-tricarballylate_Elastomeric_Fibrous_Mesh_Fabricated_by_Photoreactive_Electrospinning_for_Cardiac_Tissue_Engineering_Applications/26019496CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260194962018-04-19T06:00:00Z |
| spellingShingle | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications Hesham Ismail (12840683) Engineering Biomedical engineering Materials engineering poly(diol-tricarballylate) reactive electrospinning particulate leaching photo-crosslinking cardiac tissue engineering biocompatibility |
| status_str | publishedVersion |
| title | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| title_full | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| title_fullStr | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| title_full_unstemmed | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| title_short | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| title_sort | New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications |
| topic | Engineering Biomedical engineering Materials engineering poly(diol-tricarballylate) reactive electrospinning particulate leaching photo-crosslinking cardiac tissue engineering biocompatibility |