Therapeutic challenges in the management of osmotic demyelination syndrome
<h3>Rationale</h3><p dir="ltr">There is an increasing and compelling need for early recognition of features of osmotic demyelination syndrome (ODS), and a further attempt at correcting this even where presentation is late.</p><h3>Patient concerns</h3><...
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2020
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| _version_ | 1864513554500026368 |
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| author | Mohamed Elshafei (9376832) |
| author2 | Mohammed I. Danjuma (13569767) Rania El Tahir (20318433) |
| author2_role | author author |
| author_facet | Mohamed Elshafei (9376832) Mohammed I. Danjuma (13569767) Rania El Tahir (20318433) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed Elshafei (9376832) Mohammed I. Danjuma (13569767) Rania El Tahir (20318433) |
| dc.date.none.fl_str_mv | 2020-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md.0000000000020283 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Therapeutic_challenges_in_the_management_of_osmotic_demyelination_syndrome/27896289 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences demyelination hyponatremia osmotic |
| dc.title.none.fl_str_mv | Therapeutic challenges in the management of osmotic demyelination syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Rationale</h3><p dir="ltr">There is an increasing and compelling need for early recognition of features of osmotic demyelination syndrome (ODS), and a further attempt at correcting this even where presentation is late.</p><h3>Patient concerns</h3><p dir="ltr">A 49-year-old male admitted into the emergency department with a complaint of lethargy and severe hyponatremia, with subsequent ODS supervening on initial attempts at correction.</p><h3>Diagnosis</h3><p dir="ltr">Rapid rise in serum sodium concentration (121 mmol/L in 8 hours from a nadir of 101 mmol/L), concomitant deterioration in patient's conscious level support the diagnosis of ODS.</p><h3>Intervention</h3><p dir="ltr">Concomitant administration of 5% dextrose water with desmopressin with a therapeutic objective of gradual relowering of serum sodium concentration.</p><h3>Outcomes</h3><p dir="ltr">Significant improvement in patients’ conscious level and motor function with the commencement of sodium relowering therapy. The patient was eventually discharged home.</p><h3>Lessons</h3><p dir="ltr">Regardless of the temporal profile of neurologic sequelae following ODS due to hyponatremia, its worthwhile attempting initial sodium relowering with dextrose 5% and desmopressin and then monitoring of biochemical and neurologic markers.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000020283" target="_blank">https://dx.doi.org/10.1097/md.0000000000020283</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6465820b5e68c1715ff2d049f0123c59 |
| identifier_str_mv | 10.1097/md.0000000000020283 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27896289 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Therapeutic challenges in the management of osmotic demyelination syndromeMohamed Elshafei (9376832)Mohammed I. Danjuma (13569767)Rania El Tahir (20318433)Biomedical and clinical sciencesClinical sciencesNeurosciencesdemyelinationhyponatremiaosmotic<h3>Rationale</h3><p dir="ltr">There is an increasing and compelling need for early recognition of features of osmotic demyelination syndrome (ODS), and a further attempt at correcting this even where presentation is late.</p><h3>Patient concerns</h3><p dir="ltr">A 49-year-old male admitted into the emergency department with a complaint of lethargy and severe hyponatremia, with subsequent ODS supervening on initial attempts at correction.</p><h3>Diagnosis</h3><p dir="ltr">Rapid rise in serum sodium concentration (121 mmol/L in 8 hours from a nadir of 101 mmol/L), concomitant deterioration in patient's conscious level support the diagnosis of ODS.</p><h3>Intervention</h3><p dir="ltr">Concomitant administration of 5% dextrose water with desmopressin with a therapeutic objective of gradual relowering of serum sodium concentration.</p><h3>Outcomes</h3><p dir="ltr">Significant improvement in patients’ conscious level and motor function with the commencement of sodium relowering therapy. The patient was eventually discharged home.</p><h3>Lessons</h3><p dir="ltr">Regardless of the temporal profile of neurologic sequelae following ODS due to hyponatremia, its worthwhile attempting initial sodium relowering with dextrose 5% and desmopressin and then monitoring of biochemical and neurologic markers.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000020283" target="_blank">https://dx.doi.org/10.1097/md.0000000000020283</a></p>2020-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md.0000000000020283https://figshare.com/articles/journal_contribution/Therapeutic_challenges_in_the_management_of_osmotic_demyelination_syndrome/27896289CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/278962892020-06-01T00:00:00Z |
| spellingShingle | Therapeutic challenges in the management of osmotic demyelination syndrome Mohamed Elshafei (9376832) Biomedical and clinical sciences Clinical sciences Neurosciences demyelination hyponatremia osmotic |
| status_str | publishedVersion |
| title | Therapeutic challenges in the management of osmotic demyelination syndrome |
| title_full | Therapeutic challenges in the management of osmotic demyelination syndrome |
| title_fullStr | Therapeutic challenges in the management of osmotic demyelination syndrome |
| title_full_unstemmed | Therapeutic challenges in the management of osmotic demyelination syndrome |
| title_short | Therapeutic challenges in the management of osmotic demyelination syndrome |
| title_sort | Therapeutic challenges in the management of osmotic demyelination syndrome |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences demyelination hyponatremia osmotic |