Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses
<p dir="ltr">Conventionally, manufactured tablets do not provide flexibility for personalizing dosing to patients. Furthermore, most Active Pharmaceutical Ingredients (APIs) suffer from poor solubility. We aimed to simultaneously address these two constraints through application of a...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513551181283328 |
|---|---|
| author | Heba Iqbal (17337667) |
| author2 | Queenie Fernandes (14557388) Anis Daou (16442181) Muhammad Izham Mohamed Ibrahim (20837798) Nashiru Billa (4375261) |
| author2_role | author author author author |
| author_facet | Heba Iqbal (17337667) Queenie Fernandes (14557388) Anis Daou (16442181) Muhammad Izham Mohamed Ibrahim (20837798) Nashiru Billa (4375261) |
| author_role | author |
| dc.creator.none.fl_str_mv | Heba Iqbal (17337667) Queenie Fernandes (14557388) Anis Daou (16442181) Muhammad Izham Mohamed Ibrahim (20837798) Nashiru Billa (4375261) |
| dc.date.none.fl_str_mv | 2025-03-06T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.thradv.2025.100027 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Thermal_profiles_of_amorphous_solid_dispersions_ASD_in_3D_printed_tablets_by_fused_deposition_modelling_FDM_Production_of_tunable_tablet_doses/28546616 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Additive manufacturing Polymers3D printing Adjustable dosing Amorphous solid dispersions ibuprofen |
| dc.title.none.fl_str_mv | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Conventionally, manufactured tablets do not provide flexibility for personalizing dosing to patients. Furthermore, most Active Pharmaceutical Ingredients (APIs) suffer from poor solubility. We aimed to simultaneously address these two constraints through application of amorphous solid dispersions (ASD) and additive manufacturing such as Fused Deposition Modelling (FDM) using ibuprofen (IBU) as model drug. The ASD displayed a porous microstructure, with ibuprofen transformed from crystalline to amorphous state and a complete loss of the melting point. Aptly, there was a 35% increase in solubility and a significant increase (<i>p</i> < 0.05) in dissolution rates of ibuprofen from 3D printed ASD tablets compared to printed tablets of pure ibuprofen. It was also possible to modify the dissolution profile of ibuprofen based on changes in the dimensions of the ASD tablets, thereby providing scope for tuning doses for specific patient needs.</p><h2>Other Information</h2><p dir="ltr">Published in: Thermal Advances<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.thradv.2025.100027" target="_blank">https://dx.doi.org/10.1016/j.thradv.2025.100027</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_65ce2f2444bab4f272c7938438dba602 |
| identifier_str_mv | 10.1016/j.thradv.2025.100027 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28546616 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet dosesHeba Iqbal (17337667)Queenie Fernandes (14557388)Anis Daou (16442181)Muhammad Izham Mohamed Ibrahim (20837798)Nashiru Billa (4375261)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringNanotechnologyAdditive manufacturingPolymers3D printingAdjustable dosingAmorphous solid dispersionsibuprofen<p dir="ltr">Conventionally, manufactured tablets do not provide flexibility for personalizing dosing to patients. Furthermore, most Active Pharmaceutical Ingredients (APIs) suffer from poor solubility. We aimed to simultaneously address these two constraints through application of amorphous solid dispersions (ASD) and additive manufacturing such as Fused Deposition Modelling (FDM) using ibuprofen (IBU) as model drug. The ASD displayed a porous microstructure, with ibuprofen transformed from crystalline to amorphous state and a complete loss of the melting point. Aptly, there was a 35% increase in solubility and a significant increase (<i>p</i> < 0.05) in dissolution rates of ibuprofen from 3D printed ASD tablets compared to printed tablets of pure ibuprofen. It was also possible to modify the dissolution profile of ibuprofen based on changes in the dimensions of the ASD tablets, thereby providing scope for tuning doses for specific patient needs.</p><h2>Other Information</h2><p dir="ltr">Published in: Thermal Advances<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.thradv.2025.100027" target="_blank">https://dx.doi.org/10.1016/j.thradv.2025.100027</a></p>2025-03-06T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.thradv.2025.100027https://figshare.com/articles/journal_contribution/Thermal_profiles_of_amorphous_solid_dispersions_ASD_in_3D_printed_tablets_by_fused_deposition_modelling_FDM_Production_of_tunable_tablet_doses/28546616CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/285466162025-03-06T06:00:00Z |
| spellingShingle | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses Heba Iqbal (17337667) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Additive manufacturing Polymers3D printing Adjustable dosing Amorphous solid dispersions ibuprofen |
| status_str | publishedVersion |
| title | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| title_full | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| title_fullStr | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| title_full_unstemmed | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| title_short | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| title_sort | Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Nanotechnology Additive manufacturing Polymers3D printing Adjustable dosing Amorphous solid dispersions ibuprofen |