Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications
<p dir="ltr">Achieving the healing of chronic diabetic ulcers, burn wounds and large traumatic wounds is a major clinical challenge. A variety of approaches have been undertaken to generate skin substitutes, wound healing patches or dressings with adequate barrier properties, stabili...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Published: |
2021
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513543667187712 |
|---|---|
| author | Sumama Nuthana Kalva (17302906) |
| author2 | Robin Augustine (3976964) Abdulla Al Mamun (9557151) Yogesh Bharat Dalvi (9769460) Namitha Vijay (17302909) Anwarul Hasan (1332066) |
| author2_role | author author author author author |
| author_facet | Sumama Nuthana Kalva (17302906) Robin Augustine (3976964) Abdulla Al Mamun (9557151) Yogesh Bharat Dalvi (9769460) Namitha Vijay (17302909) Anwarul Hasan (1332066) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sumama Nuthana Kalva (17302906) Robin Augustine (3976964) Abdulla Al Mamun (9557151) Yogesh Bharat Dalvi (9769460) Namitha Vijay (17302909) Anwarul Hasan (1332066) |
| dc.date.none.fl_str_mv | 2021-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jddst.2021.102500 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Active_agents_loaded_extracellular_matrix_mimetic_electrospun_membranes_for_wound_healing_applications/24459232 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Biomimetic Extracellular matrix ECM Electrospinning Tissue regeneration Wound healing |
| dc.title.none.fl_str_mv | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Achieving the healing of chronic diabetic ulcers, burn wounds and large traumatic wounds is a major clinical challenge. A variety of approaches have been undertaken to generate skin substitutes, wound healing patches or dressings with adequate barrier properties, stability, degradation, exudate uptake capacity, antimicrobial properties, vascularization potential and wound-healing capacity. Recent approaches to support chronic wound healing focus on the development of a natural extracellular matrix (ECM) mimetic microenvironment in the wound bed. Submicron fiber-based membranes have been shown to successfully mimic many features of the ECM such as its architecture, mechanical properties, composition, and function. Electrospinning is one of the most successful methods for producing porous submicron fiber based wound coverage matrices for promoting wound healing and achieving tissue regeneration. The ECM mimetic properties of the membranes have also been improved with the use of recently developed methods such as coaxial electrospinning with other polymers. Various active components such as therapeutic agents, nanoparticles and biomolecules can be incorporated in electrospun fibers to improve ECM mimetic features and provide additional advantages like antibacterial and angiogenic properties. This article comprehensively overviews the applications of ECM mimetic electrospun membranes as structural and functional components in wound healing and the potential challenges imposed by them in a clinical point of view.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Drug Delivery Science and Technology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jddst.2021.102500" target="_blank">https://dx.doi.org/10.1016/j.jddst.2021.102500</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_672583eb581314b8fbe073179338e074 |
| identifier_str_mv | 10.1016/j.jddst.2021.102500 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24459232 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applicationsSumama Nuthana Kalva (17302906)Robin Augustine (3976964)Abdulla Al Mamun (9557151)Yogesh Bharat Dalvi (9769460)Namitha Vijay (17302909)Anwarul Hasan (1332066)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesEngineeringBiomedical engineeringBiomimeticExtracellular matrixECMElectrospinningTissue regenerationWound healing<p dir="ltr">Achieving the healing of chronic diabetic ulcers, burn wounds and large traumatic wounds is a major clinical challenge. A variety of approaches have been undertaken to generate skin substitutes, wound healing patches or dressings with adequate barrier properties, stability, degradation, exudate uptake capacity, antimicrobial properties, vascularization potential and wound-healing capacity. Recent approaches to support chronic wound healing focus on the development of a natural extracellular matrix (ECM) mimetic microenvironment in the wound bed. Submicron fiber-based membranes have been shown to successfully mimic many features of the ECM such as its architecture, mechanical properties, composition, and function. Electrospinning is one of the most successful methods for producing porous submicron fiber based wound coverage matrices for promoting wound healing and achieving tissue regeneration. The ECM mimetic properties of the membranes have also been improved with the use of recently developed methods such as coaxial electrospinning with other polymers. Various active components such as therapeutic agents, nanoparticles and biomolecules can be incorporated in electrospun fibers to improve ECM mimetic features and provide additional advantages like antibacterial and angiogenic properties. This article comprehensively overviews the applications of ECM mimetic electrospun membranes as structural and functional components in wound healing and the potential challenges imposed by them in a clinical point of view.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Drug Delivery Science and Technology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jddst.2021.102500" target="_blank">https://dx.doi.org/10.1016/j.jddst.2021.102500</a></p>2021-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jddst.2021.102500https://figshare.com/articles/journal_contribution/Active_agents_loaded_extracellular_matrix_mimetic_electrospun_membranes_for_wound_healing_applications/24459232CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/244592322021-06-01T00:00:00Z |
| spellingShingle | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications Sumama Nuthana Kalva (17302906) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Biomimetic Extracellular matrix ECM Electrospinning Tissue regeneration Wound healing |
| status_str | publishedVersion |
| title | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| title_full | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| title_fullStr | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| title_full_unstemmed | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| title_short | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| title_sort | Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Engineering Biomedical engineering Biomimetic Extracellular matrix ECM Electrospinning Tissue regeneration Wound healing |