The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
<h3>Background and Aim</h3><p dir="ltr">The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on the association between hyperten...
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2023
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| _version_ | 1864513530435207168 |
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| author | Ahmad R. Al-Qudimat (17337808) |
| author2 | Ayisha Ameen (17807381) Doaa M. Sabir (17807384) Heba Alkharraz (17807387) Mai Elaarag (17807390) Aisha Althani (17807393) Kalpana Singh (3838960) Wassim M. Alhimoney (17807396) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) |
| author2_role | author author author author author author author author author |
| author_facet | Ahmad R. Al-Qudimat (17337808) Ayisha Ameen (17807381) Doaa M. Sabir (17807384) Heba Alkharraz (17807387) Mai Elaarag (17807390) Aisha Althani (17807393) Kalpana Singh (3838960) Wassim M. Alhimoney (17807396) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmad R. Al-Qudimat (17337808) Ayisha Ameen (17807381) Doaa M. Sabir (17807384) Heba Alkharraz (17807387) Mai Elaarag (17807390) Aisha Althani (17807393) Kalpana Singh (3838960) Wassim M. Alhimoney (17807396) Raed M. Al-Zoubi (2037490) Omar M. Aboumarzouk (14779240) |
| dc.date.none.fl_str_mv | 2023-06-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s44197-023-00130-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Association_of_Hypertension_with_Increased_Mortality_Rate_During_the_COVID-19_Pandemic_An_Update_with_Meta-analysis/25018013 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Mathematical sciences Statistics HTN COVID-19 Mortality Prevalence Pandemic Chronic disease |
| dc.title.none.fl_str_mv | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background and Aim</h3><p dir="ltr">The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on the association between hypertension (HTN) and mortality in patients with COVID-19.</p><h3>Methods</h3><p dir="ltr">A systematic review and meta-analysis were performed and followed the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. A search was achieved using PubMed, Scopus, and Cochrane Databases for research publications on hypertension, COVID-19, and mortality published between December 2019 and August 2022.</p><h3>Results</h3><p dir="ltr">A total of 23 observational studies involving 611,522 patients from 5 countries (China, Korea, the UK, Australia, and the USA) were included in our study. The confirmed number of COVID-19 with HTN cases in each study ranged from 5 to 9964. The mortality ranged from 0.17% to 31% in different studies. Pooled results show that the mortality rate of COVID-19 among the included studies ranges from a minimum of 0.39 (95% CI 0.13–1.12) to a maximum of 5.74 (95% CI 3.77–8.74). Out of the 611,522 patients, 3119 died which resulted in an overall mortality prevalence of 0.5%. Subgroup analyses indicated that patients with COVID-19 who have hypertension and male patients had slightly less risk of mortality than female patients [the percentage of men > 50%; OR 1.33: 95% CI (1.01, 1.76); the percentage of men ≤ 50%: OR 2.26; and 95% CI (1.15, 4.48)]. Meta-regression analysis results also showed a statistically significant association between hypertension and COVID-19 mortality.</p><h3>Conclusion</h3><p dir="ltr">This systematic review and meta-analysis suggest that hypertension may not be the only risk factor associated with the increased mortality rate during the COVID-19 pandemic. In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Epidemiology and Global Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s44197-023-00130-3" target="_blank">https://dx.doi.org/10.1007/s44197-023-00130-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_673befa241bef0168b83a967e0251c4a |
| identifier_str_mv | 10.1007/s44197-023-00130-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25018013 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysisAhmad R. Al-Qudimat (17337808)Ayisha Ameen (17807381)Doaa M. Sabir (17807384)Heba Alkharraz (17807387)Mai Elaarag (17807390)Aisha Althani (17807393)Kalpana Singh (3838960)Wassim M. Alhimoney (17807396)Raed M. Al-Zoubi (2037490)Omar M. Aboumarzouk (14779240)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyPublic healthMathematical sciencesStatisticsHTNCOVID-19MortalityPrevalencePandemicChronic disease<h3>Background and Aim</h3><p dir="ltr">The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on the association between hypertension (HTN) and mortality in patients with COVID-19.</p><h3>Methods</h3><p dir="ltr">A systematic review and meta-analysis were performed and followed the Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. A search was achieved using PubMed, Scopus, and Cochrane Databases for research publications on hypertension, COVID-19, and mortality published between December 2019 and August 2022.</p><h3>Results</h3><p dir="ltr">A total of 23 observational studies involving 611,522 patients from 5 countries (China, Korea, the UK, Australia, and the USA) were included in our study. The confirmed number of COVID-19 with HTN cases in each study ranged from 5 to 9964. The mortality ranged from 0.17% to 31% in different studies. Pooled results show that the mortality rate of COVID-19 among the included studies ranges from a minimum of 0.39 (95% CI 0.13–1.12) to a maximum of 5.74 (95% CI 3.77–8.74). Out of the 611,522 patients, 3119 died which resulted in an overall mortality prevalence of 0.5%. Subgroup analyses indicated that patients with COVID-19 who have hypertension and male patients had slightly less risk of mortality than female patients [the percentage of men > 50%; OR 1.33: 95% CI (1.01, 1.76); the percentage of men ≤ 50%: OR 2.26; and 95% CI (1.15, 4.48)]. Meta-regression analysis results also showed a statistically significant association between hypertension and COVID-19 mortality.</p><h3>Conclusion</h3><p dir="ltr">This systematic review and meta-analysis suggest that hypertension may not be the only risk factor associated with the increased mortality rate during the COVID-19 pandemic. In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Epidemiology and Global Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s44197-023-00130-3" target="_blank">https://dx.doi.org/10.1007/s44197-023-00130-3</a></p>2023-06-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s44197-023-00130-3https://figshare.com/articles/journal_contribution/The_Association_of_Hypertension_with_Increased_Mortality_Rate_During_the_COVID-19_Pandemic_An_Update_with_Meta-analysis/25018013CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/250180132023-06-15T03:00:00Z |
| spellingShingle | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis Ahmad R. Al-Qudimat (17337808) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Mathematical sciences Statistics HTN COVID-19 Mortality Prevalence Pandemic Chronic disease |
| status_str | publishedVersion |
| title | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| title_full | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| title_fullStr | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| title_full_unstemmed | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| title_short | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| title_sort | The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Public health Mathematical sciences Statistics HTN COVID-19 Mortality Prevalence Pandemic Chronic disease |