GATA3: Orchestrating cellular fate through differentiation and proliferation
<p dir="ltr"><u>Cell proliferation</u> and differentiation are two fundamental <u>biological processes</u> that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). <u>Zinc finger proteins</u> are T...
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2024
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| Summary: | <p dir="ltr"><u>Cell proliferation</u> and differentiation are two fundamental <u>biological processes</u> that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). <u>Zinc finger proteins</u> are TFs responsible for maintaining the biological balance via coordinating development and functionality within the living cells. GATA<u> binding protein</u> 3 (GATA3), one of the zinc finger proteins, plays an essential role in driving differentiation and proliferation-related processes, thereby contributing to the regulation of the dynamism and productivity of living cells. By elucidating the complex interactions governed by GATA3, this underscores its significance in maintaining cellular <u>homeostasis</u>. Thus, the current review delves into the molecular pathways influenced by GATA3, highlighting its involvement in multiple developmental processes of various tissues and body sites, particularly in the<u> hematopoietic system</u> (T-cell differentiation), neural tissue differentiation, <u>adipose tissue</u>, as well as epithelial cell maturation.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2024.119893" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2024.119893</a></p> |
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