GATA3: Orchestrating cellular fate through differentiation and proliferation
<p dir="ltr"><u>Cell proliferation</u> and differentiation are two fundamental <u>biological processes</u> that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). <u>Zinc finger proteins</u> are T...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , |
| Published: |
2024
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513513448275968 |
|---|---|
| author | Rim Bacha (14779420) |
| author2 | Shona Pedersen (2792278) Rana Ismail (22303147) Nouran Alwisi (22303150) Layla Al-Mansoori (9522518) |
| author2_role | author author author author |
| author_facet | Rim Bacha (14779420) Shona Pedersen (2792278) Rana Ismail (22303147) Nouran Alwisi (22303150) Layla Al-Mansoori (9522518) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rim Bacha (14779420) Shona Pedersen (2792278) Rana Ismail (22303147) Nouran Alwisi (22303150) Layla Al-Mansoori (9522518) |
| dc.date.none.fl_str_mv | 2024-12-30T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.bbamcr.2024.119893 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/GATA3_Orchestrating_cellular_fate_through_differentiation_and_proliferation/30197602 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Immunology GATA3 Zinc finger proteins Transcription factors Cell proliferation Cell differentiation |
| dc.title.none.fl_str_mv | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr"><u>Cell proliferation</u> and differentiation are two fundamental <u>biological processes</u> that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). <u>Zinc finger proteins</u> are TFs responsible for maintaining the biological balance via coordinating development and functionality within the living cells. GATA<u> binding protein</u> 3 (GATA3), one of the zinc finger proteins, plays an essential role in driving differentiation and proliferation-related processes, thereby contributing to the regulation of the dynamism and productivity of living cells. By elucidating the complex interactions governed by GATA3, this underscores its significance in maintaining cellular <u>homeostasis</u>. Thus, the current review delves into the molecular pathways influenced by GATA3, highlighting its involvement in multiple developmental processes of various tissues and body sites, particularly in the<u> hematopoietic system</u> (T-cell differentiation), neural tissue differentiation, <u>adipose tissue</u>, as well as epithelial cell maturation.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2024.119893" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2024.119893</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_67708e4b04b9312f97c3f54b57ef7c16 |
| identifier_str_mv | 10.1016/j.bbamcr.2024.119893 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30197602 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | GATA3: Orchestrating cellular fate through differentiation and proliferationRim Bacha (14779420)Shona Pedersen (2792278)Rana Ismail (22303147)Nouran Alwisi (22303150)Layla Al-Mansoori (9522518)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesImmunologyGATA3Zinc finger proteinsTranscription factorsCell proliferationCell differentiation<p dir="ltr"><u>Cell proliferation</u> and differentiation are two fundamental <u>biological processes</u> that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). <u>Zinc finger proteins</u> are TFs responsible for maintaining the biological balance via coordinating development and functionality within the living cells. GATA<u> binding protein</u> 3 (GATA3), one of the zinc finger proteins, plays an essential role in driving differentiation and proliferation-related processes, thereby contributing to the regulation of the dynamism and productivity of living cells. By elucidating the complex interactions governed by GATA3, this underscores its significance in maintaining cellular <u>homeostasis</u>. Thus, the current review delves into the molecular pathways influenced by GATA3, highlighting its involvement in multiple developmental processes of various tissues and body sites, particularly in the<u> hematopoietic system</u> (T-cell differentiation), neural tissue differentiation, <u>adipose tissue</u>, as well as epithelial cell maturation.</p><h2>Other Information</h2><p dir="ltr">Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbamcr.2024.119893" target="_blank">https://dx.doi.org/10.1016/j.bbamcr.2024.119893</a></p>2024-12-30T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.bbamcr.2024.119893https://figshare.com/articles/journal_contribution/GATA3_Orchestrating_cellular_fate_through_differentiation_and_proliferation/30197602CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301976022024-12-30T18:00:00Z |
| spellingShingle | GATA3: Orchestrating cellular fate through differentiation and proliferation Rim Bacha (14779420) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Immunology GATA3 Zinc finger proteins Transcription factors Cell proliferation Cell differentiation |
| status_str | publishedVersion |
| title | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| title_full | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| title_fullStr | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| title_full_unstemmed | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| title_short | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| title_sort | GATA3: Orchestrating cellular fate through differentiation and proliferation |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Immunology GATA3 Zinc finger proteins Transcription factors Cell proliferation Cell differentiation |