Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium
<p></p><div> <p>Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, anti-inflammatory, and pro-survival actions....
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2023
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| _version_ | 1864513565255270400 |
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| author | Matshediso Zachariah (13878830) |
| author2 | Hatem Maamoun (14778730) Larissa Milano (14133591) Margaret P. Rayman (14778733) Lisiane B. Meira (14778736) Abdelali Agouni (181926) |
| author2_role | author author author author author |
| author_facet | Matshediso Zachariah (13878830) Hatem Maamoun (14778730) Larissa Milano (14133591) Margaret P. Rayman (14778733) Lisiane B. Meira (14778736) Abdelali Agouni (181926) |
| author_role | author |
| dc.creator.none.fl_str_mv | Matshediso Zachariah (13878830) Hatem Maamoun (14778730) Larissa Milano (14133591) Margaret P. Rayman (14778733) Lisiane B. Meira (14778736) Abdelali Agouni (181926) |
| dc.date.none.fl_str_mv | 2023-03-16T06:23:34Z |
| dc.identifier.none.fl_str_mv | 10.1002/jcp.30175 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Endoplasmic_reticulum_stress_and_oxidative_stress_drive_endothelial_dysfunction_induced_by_high_selenium/22258207 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Cell Biology Clinical Biochemistry Physiology |
| dc.title.none.fl_str_mv | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p></p><div> <p>Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, anti-inflammatory, and pro-survival actions. However, supra-nutritional selenium intake was associated with increased diabetes risk leading potentially to endothelial dysfunction, the initiating step in atherosclerosis. High selenium causes apoptosis in cancer cells via endoplasmic reticulum (ER) stress, a mechanism also implicated in endothelial dysfunction. Nonetheless, whether ER stress drives selenium-induced endothelial dysfunction, remains unknown. Here, we investigated the effects of increasing concentrations of selenium on endothelial cells. High selenite reduced nitric oxide bioavailability and impaired angiogenesis. High selenite also induced ER stress, increased reactive oxygen species (ROS) production, and apoptosis. Pretreatment with the chemical chaperone, 4-phenylbutyrate, prevented the toxic effects of selenium. Our findings support a model where high selenite leads to endothelial dysfunction through activation of ER stress and increased ROS production. These results highlight the importance of tailoring selenium supplementation to achieve maximal health benefits and suggest that prophylactic use of selenium supplements as antioxidants may entail risk.</p></div><p></p><h2>Other Information</h2> <p> Published in: Journal of Cellular Physiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/jcp.30175" target="_blank">http://dx.doi.org/10.1002/jcp.30175</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_68603fcc35ee005be167153d263c47af |
| identifier_str_mv | 10.1002/jcp.30175 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258207 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high seleniumMatshediso Zachariah (13878830)Hatem Maamoun (14778730)Larissa Milano (14133591)Margaret P. Rayman (14778733)Lisiane B. Meira (14778736)Abdelali Agouni (181926)Biological sciencesBiochemistry and cell biologyCell BiologyClinical BiochemistryPhysiology<p></p><div> <p>Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, anti-inflammatory, and pro-survival actions. However, supra-nutritional selenium intake was associated with increased diabetes risk leading potentially to endothelial dysfunction, the initiating step in atherosclerosis. High selenium causes apoptosis in cancer cells via endoplasmic reticulum (ER) stress, a mechanism also implicated in endothelial dysfunction. Nonetheless, whether ER stress drives selenium-induced endothelial dysfunction, remains unknown. Here, we investigated the effects of increasing concentrations of selenium on endothelial cells. High selenite reduced nitric oxide bioavailability and impaired angiogenesis. High selenite also induced ER stress, increased reactive oxygen species (ROS) production, and apoptosis. Pretreatment with the chemical chaperone, 4-phenylbutyrate, prevented the toxic effects of selenium. Our findings support a model where high selenite leads to endothelial dysfunction through activation of ER stress and increased ROS production. These results highlight the importance of tailoring selenium supplementation to achieve maximal health benefits and suggest that prophylactic use of selenium supplements as antioxidants may entail risk.</p></div><p></p><h2>Other Information</h2> <p> Published in: Journal of Cellular Physiology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/jcp.30175" target="_blank">http://dx.doi.org/10.1002/jcp.30175</a></p>2023-03-16T06:23:34ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/jcp.30175https://figshare.com/articles/journal_contribution/Endoplasmic_reticulum_stress_and_oxidative_stress_drive_endothelial_dysfunction_induced_by_high_selenium/22258207CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222582072023-03-16T06:23:34Z |
| spellingShingle | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium Matshediso Zachariah (13878830) Biological sciences Biochemistry and cell biology Cell Biology Clinical Biochemistry Physiology |
| status_str | publishedVersion |
| title | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| title_full | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| title_fullStr | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| title_full_unstemmed | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| title_short | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| title_sort | Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium |
| topic | Biological sciences Biochemistry and cell biology Cell Biology Clinical Biochemistry Physiology |