Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease
<p dir="ltr">Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction inhibitors that reduce α-synuclei...
محفوظ في:
| المؤلف الرئيسي: | Satra Nim (11540447) (author) |
|---|---|
| مؤلفون آخرون: | Darren M. O’Hara (9201761) (author), Carles Corbi-Verge (527968) (author), Albert Perez-Riba (5004785) (author), Kazuko Fujisawa (11692038) (author), Minesh Kapadia (582056) (author), Hien Chau (355945) (author), Federica Albanese (19482364) (author), Grishma Pawar (10666899) (author), Mitchell L. De Snoo (19482367) (author), Sophie G. Ngana (19482370) (author), Jisun Kim (837555) (author), Omar M. A. El-Agnaf (8809331) (author), Enrico Rennella (2083291) (author), Lewis E. Kay (135973) (author), Suneil K. Kalia (9201773) (author), Lorraine V. Kalia (9201770) (author), Philip M. Kim (11540462) (author) |
| منشور في: |
2023
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| الموضوعات: | |
| الوسوم: |
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