Thrombotic and Hypercoagulability Complications of COVID-19: An Update
<p dir="ltr">The current COVID-19 pandemic emerged in December 2019, in China, affecting millions of people worldwide. COVID-19 is mainly a disease of the respiratory system, yet systematic complications have also been reported among SARS-CoV-2 infected patients. Thrombotic complicat...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513552239296512 |
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| author | Sapha Shibeeb (7903268) |
| author2 | Muneera Naseer Ahmad (20414102) |
| author2_role | author |
| author_facet | Sapha Shibeeb (7903268) Muneera Naseer Ahmad (20414102) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sapha Shibeeb (7903268) Muneera Naseer Ahmad (20414102) |
| dc.date.none.fl_str_mv | 2021-08-31T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/jbm.s316014 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Thrombotic_and_Hypercoagulability_Complications_of_COVID-19_An_Update/28006082 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 SARS-CoV-2 thrombosis thromboembolism |
| dc.title.none.fl_str_mv | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The current COVID-19 pandemic emerged in December 2019, in China, affecting millions of people worldwide. COVID-19 is mainly a disease of the respiratory system, yet systematic complications have also been reported among SARS-CoV-2 infected patients. Thrombotic complications are one of the severe clinical outcomes of COVID-19, especially among critically ill patients, and are associated with poor prognosis. To date, many studies have concluded that COVID-19 increases the incidence of thrombotic events and coagulopathies; however, the exact mechanism behind such a disease outcome is not well known. Various pathophysiological mechanisms for thrombotic events in COVID-19 have been proposed, these include virus-induced endothelial cell damage, inflammation, and excess production of pro-inflammatory cytokines. As a result, most critically diseased COVID-19 patients are managed with prophylactic anticoagulant, yet some still develop thrombotic episodes. Therefore, better understanding of the mechanisms behind the thrombotic complications is needed to develop treatments that specifically target such pathways, which may aid in better disease management and improve the prognosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Blood Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/jbm.s316014" target="_blank">https://dx.doi.org/10.2147/jbm.s316014</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_696373d5275f03d41a2b072eaf638c3b |
| identifier_str_mv | 10.2147/jbm.s316014 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28006082 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Thrombotic and Hypercoagulability Complications of COVID-19: An UpdateSapha Shibeeb (7903268)Muneera Naseer Ahmad (20414102)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesCOVID-19SARS-CoV-2thrombosisthromboembolism<p dir="ltr">The current COVID-19 pandemic emerged in December 2019, in China, affecting millions of people worldwide. COVID-19 is mainly a disease of the respiratory system, yet systematic complications have also been reported among SARS-CoV-2 infected patients. Thrombotic complications are one of the severe clinical outcomes of COVID-19, especially among critically ill patients, and are associated with poor prognosis. To date, many studies have concluded that COVID-19 increases the incidence of thrombotic events and coagulopathies; however, the exact mechanism behind such a disease outcome is not well known. Various pathophysiological mechanisms for thrombotic events in COVID-19 have been proposed, these include virus-induced endothelial cell damage, inflammation, and excess production of pro-inflammatory cytokines. As a result, most critically diseased COVID-19 patients are managed with prophylactic anticoagulant, yet some still develop thrombotic episodes. Therefore, better understanding of the mechanisms behind the thrombotic complications is needed to develop treatments that specifically target such pathways, which may aid in better disease management and improve the prognosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Blood Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/jbm.s316014" target="_blank">https://dx.doi.org/10.2147/jbm.s316014</a></p>2021-08-31T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/jbm.s316014https://figshare.com/articles/journal_contribution/Thrombotic_and_Hypercoagulability_Complications_of_COVID-19_An_Update/28006082CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/280060822021-08-31T03:00:00Z |
| spellingShingle | Thrombotic and Hypercoagulability Complications of COVID-19: An Update Sapha Shibeeb (7903268) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 SARS-CoV-2 thrombosis thromboembolism |
| status_str | publishedVersion |
| title | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| title_full | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| title_fullStr | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| title_full_unstemmed | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| title_short | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| title_sort | Thrombotic and Hypercoagulability Complications of COVID-19: An Update |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences COVID-19 SARS-CoV-2 thrombosis thromboembolism |