Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study
<p dir="ltr">The relationship between salivary α-amylase activity (ssAAa) and the risk of metabolic disorders remains equivocal. We aimed to assess this relationship in adults from Qatar, where obesity and type 2 diabetes are highly prevalent. We cross-sectionally quantified ssAAa in...
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2022
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| _version_ | 1864513526484172800 |
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| author | Neyla Al-Akl (12225508) |
| author2 | Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| author2_role | author author |
| author_facet | Neyla Al-Akl (12225508) Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| author_role | author |
| dc.creator.none.fl_str_mv | Neyla Al-Akl (12225508) Richard I. Thompson (2308105) Abdelilah Arredouani (10914455) |
| dc.date.none.fl_str_mv | 2022-03-10T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0264692 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Elevated_levels_of_salivary_-_amylase_activity_in_saliva_associated_with_reduced_odds_of_obesity_in_adult_Qatari_citizens_A_cross-sectional_study/25257232 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical physiology Health sciences Public health Salivary α-amylase (sAA) Starch digestion Small intestine AMY1 gene Copy-Number Variation (CNV) Glycemic markers Postprandial glycemia Insulin resistance Obesity Diabetes Qatari adults Qatar Biobank (QBB) Blood biochemistry HbA1c BMI (Body Mass Index) Homeostasis Model Assessment (HOMA) β-cell function Visceral adipose tissue Salivary α-amylase activity (ssAAa) Colorimetric kinetic enzyme assay Prediabetes |
| dc.title.none.fl_str_mv | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The relationship between salivary α-amylase activity (ssAAa) and the risk of metabolic disorders remains equivocal. We aimed to assess this relationship in adults from Qatar, where obesity and type 2 diabetes are highly prevalent. We cross-sectionally quantified ssAAa in saliva and estimated AMY1 CN from whole-genome sequencing data from 1499 participants. Linear regression was used to assess the relationship between ssAAa and adiposity and glycemic markers. Logistic regression was used to examine the association between ssAAa and occurrence of obesity or diabetes. The mean and median ssAAa were significantly lower in obese individuals. There were significant inverse associations between ssAAa and BMI, and fat mass. We detected a marked effect of ssAAa on reduced odds of obesity after adjusting for age and sex, glucose, LDL, HLD, total cholesterol, and systolic and diastolic blood pressure (OR per ssAAa unit 0.998 [95% CI 0.996–0.999], p = 0.005), with ssAAa ranging between 6.8 and 422U/mL. The obesity odds were significantly lower in the upper half of the ssAAa distributional (OR 0.58 [95% CI 0.42–0.76], p<0.001) and lower in the top versus the bottom decile of the ssAAa distribution (OR 0.46 [95% CI 0.23–0.92], p = 0.03). Our findings suggest a potential beneficial relationship between high sAAa in saliva and low odds of obesity in Qatari adults.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0264692" target="_blank">https://dx.doi.org/10.1371/journal.pone.0264692</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_697f52d3eafd8fd7402e2e177bf3aba0 |
| identifier_str_mv | 10.1371/journal.pone.0264692 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25257232 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional studyNeyla Al-Akl (12225508)Richard I. Thompson (2308105)Abdelilah Arredouani (10914455)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesMedical physiologyHealth sciencesPublic healthSalivary α-amylase (sAA)Starch digestionSmall intestineAMY1 geneCopy-Number Variation (CNV)Glycemic markersPostprandial glycemiaInsulin resistanceObesityDiabetesQatari adultsQatar Biobank (QBB)Blood biochemistryHbA1cBMI (Body Mass Index)Homeostasis Model Assessment (HOMA)β-cell functionVisceral adipose tissueSalivary α-amylase activity (ssAAa)Colorimetric kinetic enzyme assayPrediabetes<p dir="ltr">The relationship between salivary α-amylase activity (ssAAa) and the risk of metabolic disorders remains equivocal. We aimed to assess this relationship in adults from Qatar, where obesity and type 2 diabetes are highly prevalent. We cross-sectionally quantified ssAAa in saliva and estimated AMY1 CN from whole-genome sequencing data from 1499 participants. Linear regression was used to assess the relationship between ssAAa and adiposity and glycemic markers. Logistic regression was used to examine the association between ssAAa and occurrence of obesity or diabetes. The mean and median ssAAa were significantly lower in obese individuals. There were significant inverse associations between ssAAa and BMI, and fat mass. We detected a marked effect of ssAAa on reduced odds of obesity after adjusting for age and sex, glucose, LDL, HLD, total cholesterol, and systolic and diastolic blood pressure (OR per ssAAa unit 0.998 [95% CI 0.996–0.999], p = 0.005), with ssAAa ranging between 6.8 and 422U/mL. The obesity odds were significantly lower in the upper half of the ssAAa distributional (OR 0.58 [95% CI 0.42–0.76], p<0.001) and lower in the top versus the bottom decile of the ssAAa distribution (OR 0.46 [95% CI 0.23–0.92], p = 0.03). Our findings suggest a potential beneficial relationship between high sAAa in saliva and low odds of obesity in Qatari adults.</p><h2>Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0264692" target="_blank">https://dx.doi.org/10.1371/journal.pone.0264692</a></p>2022-03-10T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0264692https://figshare.com/articles/journal_contribution/Elevated_levels_of_salivary_-_amylase_activity_in_saliva_associated_with_reduced_odds_of_obesity_in_adult_Qatari_citizens_A_cross-sectional_study/25257232CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252572322022-03-10T03:00:00Z |
| spellingShingle | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study Neyla Al-Akl (12225508) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical physiology Health sciences Public health Salivary α-amylase (sAA) Starch digestion Small intestine AMY1 gene Copy-Number Variation (CNV) Glycemic markers Postprandial glycemia Insulin resistance Obesity Diabetes Qatari adults Qatar Biobank (QBB) Blood biochemistry HbA1c BMI (Body Mass Index) Homeostasis Model Assessment (HOMA) β-cell function Visceral adipose tissue Salivary α-amylase activity (ssAAa) Colorimetric kinetic enzyme assay Prediabetes |
| status_str | publishedVersion |
| title | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| title_full | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| title_fullStr | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| title_full_unstemmed | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| title_short | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| title_sort | Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Medical physiology Health sciences Public health Salivary α-amylase (sAA) Starch digestion Small intestine AMY1 gene Copy-Number Variation (CNV) Glycemic markers Postprandial glycemia Insulin resistance Obesity Diabetes Qatari adults Qatar Biobank (QBB) Blood biochemistry HbA1c BMI (Body Mass Index) Homeostasis Model Assessment (HOMA) β-cell function Visceral adipose tissue Salivary α-amylase activity (ssAAa) Colorimetric kinetic enzyme assay Prediabetes |