Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target
<p dir="ltr">The role of Epstein–Barr virus (EBV) infection in the development and progression of tumor cells has been described in various cancers. Etiologically, EBV is a causative agent in certain variants of head and neck cancers such as nasopharyngeal cancer. Proteins expressed...
محفوظ في:
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2018
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إضافة وسم
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| _version_ | 1864513525953593344 |
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| author | Queenie Fernandes (14557388) |
| author2 | Maysaloun Merhi (4246147) Afsheen Raza (492657) Varghese Philipose Inchakalody (14153292) Nassima Abdelouahab (2437603) Abdul Rehman Zar Gul (14777347) Shahab Uddin (154400) Said Dermime (79420) |
| author2_role | author author author author author author author |
| author_facet | Queenie Fernandes (14557388) Maysaloun Merhi (4246147) Afsheen Raza (492657) Varghese Philipose Inchakalody (14153292) Nassima Abdelouahab (2437603) Abdul Rehman Zar Gul (14777347) Shahab Uddin (154400) Said Dermime (79420) |
| author_role | author |
| dc.creator.none.fl_str_mv | Queenie Fernandes (14557388) Maysaloun Merhi (4246147) Afsheen Raza (492657) Varghese Philipose Inchakalody (14153292) Nassima Abdelouahab (2437603) Abdul Rehman Zar Gul (14777347) Shahab Uddin (154400) Said Dermime (79420) |
| dc.date.none.fl_str_mv | 2018-07-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2018.00257 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Role_of_Epstein_Barr_Virus_in_the_Pathogenesis_of_Head_and_Neck_Cancers_and_Its_Potential_as_an_Immunotherapeutic_Target/25331029 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Epstein–Barr virus head and neck cancers nasopharyngeal cancer EBV-induced nuclear antigen 1 LMP cancer vaccine virus-specific T cells cancer immunotherapy |
| dc.title.none.fl_str_mv | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The role of Epstein–Barr virus (EBV) infection in the development and progression of tumor cells has been described in various cancers. Etiologically, EBV is a causative agent in certain variants of head and neck cancers such as nasopharyngeal cancer. Proteins expressed by the EVB genome are involved in invoking and perpetuating the oncogenic properties of the virus. However, these protein products were also identified as important targets for therapeutic research in the past decades, particularly within the context of immunotherapy. The adoptive transfer of EBV-targeted T-cells as well as the development of EBV vaccines has opened newer lines of research to conceptualize novel therapeutic approaches toward the disease. This review addresses the most important aspects of the association of EBV with head and neck cancers from an immunological perspective. It also aims to highlight the current and future prospects of enhanced EBV-targeted immunotherapies.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2018.00257" target="_blank">https://dx.doi.org/10.3389/fonc.2018.00257</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6a15291c62df00c3161d22b863cb0001 |
| identifier_str_mv | 10.3389/fonc.2018.00257 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25331029 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic TargetQueenie Fernandes (14557388)Maysaloun Merhi (4246147)Afsheen Raza (492657)Varghese Philipose Inchakalody (14153292)Nassima Abdelouahab (2437603)Abdul Rehman Zar Gul (14777347)Shahab Uddin (154400)Said Dermime (79420)Biomedical and clinical sciencesOncology and carcinogenesisEpstein–Barr virushead and neck cancersnasopharyngeal cancerEBV-induced nuclear antigen 1LMPcancer vaccinevirus-specific T cellscancer immunotherapy<p dir="ltr">The role of Epstein–Barr virus (EBV) infection in the development and progression of tumor cells has been described in various cancers. Etiologically, EBV is a causative agent in certain variants of head and neck cancers such as nasopharyngeal cancer. Proteins expressed by the EVB genome are involved in invoking and perpetuating the oncogenic properties of the virus. However, these protein products were also identified as important targets for therapeutic research in the past decades, particularly within the context of immunotherapy. The adoptive transfer of EBV-targeted T-cells as well as the development of EBV vaccines has opened newer lines of research to conceptualize novel therapeutic approaches toward the disease. This review addresses the most important aspects of the association of EBV with head and neck cancers from an immunological perspective. It also aims to highlight the current and future prospects of enhanced EBV-targeted immunotherapies.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2018.00257" target="_blank">https://dx.doi.org/10.3389/fonc.2018.00257</a></p>2018-07-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fonc.2018.00257https://figshare.com/articles/journal_contribution/Role_of_Epstein_Barr_Virus_in_the_Pathogenesis_of_Head_and_Neck_Cancers_and_Its_Potential_as_an_Immunotherapeutic_Target/25331029CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253310292018-07-06T03:00:00Z |
| spellingShingle | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target Queenie Fernandes (14557388) Biomedical and clinical sciences Oncology and carcinogenesis Epstein–Barr virus head and neck cancers nasopharyngeal cancer EBV-induced nuclear antigen 1 LMP cancer vaccine virus-specific T cells cancer immunotherapy |
| status_str | publishedVersion |
| title | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| title_full | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| title_fullStr | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| title_full_unstemmed | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| title_short | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| title_sort | Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Epstein–Barr virus head and neck cancers nasopharyngeal cancer EBV-induced nuclear antigen 1 LMP cancer vaccine virus-specific T cells cancer immunotherapy |