Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity
<h3 dir="ltr">Purpose</h3><p dir="ltr">The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. N...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2025
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إضافة وسم
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| _version_ | 1864513524413235200 |
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| author | Ayman Alzu’bi (13162392) |
| author2 | Ejlal Abu-El-Rub (5168183) Fatimah A. Almahasneh (22224547) Rawan Almazari (21842705) Amani Kasasbeh (22330402) Heba F. AI-jariri (22224550) Amneh Alrabie (23073376) Raed M. Al-Zoubi (2037490) |
| author2_role | author author author author author author author |
| author_facet | Ayman Alzu’bi (13162392) Ejlal Abu-El-Rub (5168183) Fatimah A. Almahasneh (22224547) Rawan Almazari (21842705) Amani Kasasbeh (22330402) Heba F. AI-jariri (22224550) Amneh Alrabie (23073376) Raed M. Al-Zoubi (2037490) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ayman Alzu’bi (13162392) Ejlal Abu-El-Rub (5168183) Fatimah A. Almahasneh (22224547) Rawan Almazari (21842705) Amani Kasasbeh (22330402) Heba F. AI-jariri (22224550) Amneh Alrabie (23073376) Raed M. Al-Zoubi (2037490) |
| dc.date.none.fl_str_mv | 2025-10-13T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11419-025-00739-y |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Synthetic_Cannabinoid_AB-FUBINACA_Negatively_Impacted_the_Male_Fertility_and_Induced_Testicular_Toxicity/31168612 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Male fertility Oxidative stress Apoptosis |
| dc.title.none.fl_str_mv | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Purpose</h3><p dir="ltr">The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. Nevertheless, little is known about the effects of these substances on male fertility. The current study aimed to investigate the toxicological effects of subacute exposure to synthetic cannabinoid AB-FUBINACA on male reproductive system in mice.</p><h3 dir="ltr">Methods</h3><p dir="ltr">Adult male Balb/c mice received daily intraperitoneal injections of various doses of AB-FUBINACA (0.75, 1.5, and 3 mg/kg for 3 weeks). Using biochemical and molecular methodologies, the impact of AB-FUBINACA on serum levels of reproductive hormones, sperm viability as well as various parameters in testicular tissue were evaluated.</p><h3 dir="ltr">Results</h3><p dir="ltr">Our findings demonstrated that AB-FUBINACA induces dose-dependent reduction in testosterone levels in the serum, but not in follicle-stimulating hormone or luteinizing hormone. AB-FUBINACA treatment also causes a significant dose related decrease in sperm viability. These findings were associated with higher level of oxidative stress (GP91 expression and malondialdehyde level) and elevated expression of key regulators of apoptosis (Bax and caspase-3) as well as reduced expression of mitochondrial respiratory chain complexes SDHB (II), UQCRC2 (III), and ATP5a (V) in the testicular tissue.</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">From these findings, it can be concluded that exposure to AB-FUBINACA can interfere with the normal physiology and functioning of the male reproductive organs. Hence, gaining insight into the mechanisms by which SCs interfere with male fertility could guide future interventions and treatments.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Forensic Toxicology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11419-025-00739-y" target="_blank">https://dx.doi.org/10.1007/s11419-025-00739-y</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6a3b3437122b1a004fe0f0f2173c4903 |
| identifier_str_mv | 10.1007/s11419-025-00739-y |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31168612 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular ToxicityAyman Alzu’bi (13162392)Ejlal Abu-El-Rub (5168183)Fatimah A. Almahasneh (22224547)Rawan Almazari (21842705)Amani Kasasbeh (22330402)Heba F. AI-jariri (22224550)Amneh Alrabie (23073376)Raed M. Al-Zoubi (2037490)Biomedical and clinical sciencesMedical biochemistry and metabolomicsPharmacology and pharmaceutical sciencesSynthetic cannabinoidsAB-FUBINACAMale fertilityOxidative stressApoptosis<h3 dir="ltr">Purpose</h3><p dir="ltr">The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. Nevertheless, little is known about the effects of these substances on male fertility. The current study aimed to investigate the toxicological effects of subacute exposure to synthetic cannabinoid AB-FUBINACA on male reproductive system in mice.</p><h3 dir="ltr">Methods</h3><p dir="ltr">Adult male Balb/c mice received daily intraperitoneal injections of various doses of AB-FUBINACA (0.75, 1.5, and 3 mg/kg for 3 weeks). Using biochemical and molecular methodologies, the impact of AB-FUBINACA on serum levels of reproductive hormones, sperm viability as well as various parameters in testicular tissue were evaluated.</p><h3 dir="ltr">Results</h3><p dir="ltr">Our findings demonstrated that AB-FUBINACA induces dose-dependent reduction in testosterone levels in the serum, but not in follicle-stimulating hormone or luteinizing hormone. AB-FUBINACA treatment also causes a significant dose related decrease in sperm viability. These findings were associated with higher level of oxidative stress (GP91 expression and malondialdehyde level) and elevated expression of key regulators of apoptosis (Bax and caspase-3) as well as reduced expression of mitochondrial respiratory chain complexes SDHB (II), UQCRC2 (III), and ATP5a (V) in the testicular tissue.</p><h3 dir="ltr">Conclusion</h3><p dir="ltr">From these findings, it can be concluded that exposure to AB-FUBINACA can interfere with the normal physiology and functioning of the male reproductive organs. Hence, gaining insight into the mechanisms by which SCs interfere with male fertility could guide future interventions and treatments.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Forensic Toxicology<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11419-025-00739-y" target="_blank">https://dx.doi.org/10.1007/s11419-025-00739-y</a></p>2025-10-13T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11419-025-00739-yhttps://figshare.com/articles/journal_contribution/Synthetic_Cannabinoid_AB-FUBINACA_Negatively_Impacted_the_Male_Fertility_and_Induced_Testicular_Toxicity/31168612CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/311686122025-10-13T09:00:00Z |
| spellingShingle | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity Ayman Alzu’bi (13162392) Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Male fertility Oxidative stress Apoptosis |
| status_str | publishedVersion |
| title | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| title_full | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| title_fullStr | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| title_full_unstemmed | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| title_short | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| title_sort | Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Pharmacology and pharmaceutical sciences Synthetic cannabinoids AB-FUBINACA Male fertility Oxidative stress Apoptosis |