12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase

12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase

<p dir="ltr">The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical cell-substrate impedance sensing (ECIS) were used to...

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Bibliographic Details
Main Author: Amira Othman (380131) (author)
Other Authors: Saif Ahmad (371052) (author), Sylvia Megyerdi (380132) (author), Rene Mussell (380133) (author), Karishma Choksi (380134) (author), Krishna Rao Maddipati (10950942) (author), Ahmed Elmarakby (380136) (author), Nasser Rizk (380137) (author), Mohamed Al-Shabrawey (380138) (author)
Published: 2013
Subjects:
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Ophthalmology and optometry
Diabetes mellitus
Retina
Inflammation
Endothelial cells
Lipid metabolism
Mouse models
Vascular permeability
Metabolites
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