Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis
<h3>Background</h3><p dir="ltr">Necrotizing Fasciitis (NF) is a life-threatening infection characterized by rapid tissue destruction and high mortality. The role of timely diagnosis and surgical intervention in improving patient outcomes remains debated. This study invest...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2025
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| _version_ | 1864513537129316352 |
|---|---|
| author | Murad S. Alahmad (22457605) |
| author2 | Ayman El-Menyar (440103) Husham Abdelrahman (768893) Meiad A. Abdelrahman (22457608) Fahad Aurif (22457611) Nissar Shaikh (11659441) Hassan Al-Thani (440106) |
| author2_role | author author author author author author |
| author_facet | Murad S. Alahmad (22457605) Ayman El-Menyar (440103) Husham Abdelrahman (768893) Meiad A. Abdelrahman (22457608) Fahad Aurif (22457611) Nissar Shaikh (11659441) Hassan Al-Thani (440106) |
| author_role | author |
| dc.creator.none.fl_str_mv | Murad S. Alahmad (22457605) Ayman El-Menyar (440103) Husham Abdelrahman (768893) Meiad A. Abdelrahman (22457608) Fahad Aurif (22457611) Nissar Shaikh (11659441) Hassan Al-Thani (440106) |
| dc.date.none.fl_str_mv | 2025-03-18T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00068-025-02816-8 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Time_to_diagnose_and_time_to_surgery_in_patients_presenting_with_necrotizing_fasciitis_a_retrospective_analysis/30393139 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Necrotizing fasciitis Time to diagnosis Time to intervention |
| dc.title.none.fl_str_mv | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Necrotizing Fasciitis (NF) is a life-threatening infection characterized by rapid tissue destruction and high mortality. The role of timely diagnosis and surgical intervention in improving patient outcomes remains debated. This study investigates the impact of “time to diagnosis” (TTD) and “time to surgical treatment” (TTS) on the outcomes of NF patients, with a specific focus on the first six hours of critical diagnosis.</p><h3>Methods</h3><p dir="ltr">A retrospective analysis was conducted for patients hospitalized with NF between June 2016 and June 2023. Demographic data, comorbidities, clinical features, treatment, and outcomes were analyzed. The study stratified patients based on TTD (early (≤ 6 h) vs. delayed (> 6 h) and TTS (≤ 6 vs. > 6 h). Outcomes included severity scores, intensive care unit admission, length of stay (LOS), and mortality.</p><h3>Results</h3><p dir="ltr">One hundred and twenty-one patients were diagnosed with NF with a mortality rate of 10%. Early diagnosis (≤ 6 h) was associated with lower mortality (5.7% vs. 13.2%) and shorter LOS (17 vs. 27 days) compared to delayed diagnosis. Early diagnosis was associated with a lower Sequential Organ Failure Assessment (SOFA) score compared to delayed diagnosis (<i>p</i> = 0.02). A combined analysis of TTD and TTS revealed that the group with early diagnosis and early treatment (TTD and TTS were ≤ 6 h) had a 3% mortality rate, and 7% of them had a SOFA score > 9. In contrast, delayed diagnosis (TTD > 6 h) was significantly associated with increased mortality, regardless of the TTS.</p><h3>Conclusion</h3><p dir="ltr">Timely diagnosis within 6 h is crucial for improving outcomes in NF. While early surgical intervention is vital, our findings suggest that the time to diagnosis and subsequent resuscitation efforts may significantly impact survival. This study highlights the importance of optimizing early recognition and diagnosis in the emergency room to reduce delays and improve patient prognosis in NF. Further multicenter studies are needed to validate these findings and refine clinical protocols.</p><h2>Other Information</h2><p dir="ltr">Published in: European Journal of Trauma and Emergency Surgery<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00068-025-02816-8" target="_blank">https://dx.doi.org/10.1007/s00068-025-02816-8</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6ab3bb215643ce0f9175024efc0c3f39 |
| identifier_str_mv | 10.1007/s00068-025-02816-8 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30393139 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysisMurad S. Alahmad (22457605)Ayman El-Menyar (440103)Husham Abdelrahman (768893)Meiad A. Abdelrahman (22457608)Fahad Aurif (22457611)Nissar Shaikh (11659441)Hassan Al-Thani (440106)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyNecrotizing fasciitisTime to diagnosisTime to intervention<h3>Background</h3><p dir="ltr">Necrotizing Fasciitis (NF) is a life-threatening infection characterized by rapid tissue destruction and high mortality. The role of timely diagnosis and surgical intervention in improving patient outcomes remains debated. This study investigates the impact of “time to diagnosis” (TTD) and “time to surgical treatment” (TTS) on the outcomes of NF patients, with a specific focus on the first six hours of critical diagnosis.</p><h3>Methods</h3><p dir="ltr">A retrospective analysis was conducted for patients hospitalized with NF between June 2016 and June 2023. Demographic data, comorbidities, clinical features, treatment, and outcomes were analyzed. The study stratified patients based on TTD (early (≤ 6 h) vs. delayed (> 6 h) and TTS (≤ 6 vs. > 6 h). Outcomes included severity scores, intensive care unit admission, length of stay (LOS), and mortality.</p><h3>Results</h3><p dir="ltr">One hundred and twenty-one patients were diagnosed with NF with a mortality rate of 10%. Early diagnosis (≤ 6 h) was associated with lower mortality (5.7% vs. 13.2%) and shorter LOS (17 vs. 27 days) compared to delayed diagnosis. Early diagnosis was associated with a lower Sequential Organ Failure Assessment (SOFA) score compared to delayed diagnosis (<i>p</i> = 0.02). A combined analysis of TTD and TTS revealed that the group with early diagnosis and early treatment (TTD and TTS were ≤ 6 h) had a 3% mortality rate, and 7% of them had a SOFA score > 9. In contrast, delayed diagnosis (TTD > 6 h) was significantly associated with increased mortality, regardless of the TTS.</p><h3>Conclusion</h3><p dir="ltr">Timely diagnosis within 6 h is crucial for improving outcomes in NF. While early surgical intervention is vital, our findings suggest that the time to diagnosis and subsequent resuscitation efforts may significantly impact survival. This study highlights the importance of optimizing early recognition and diagnosis in the emergency room to reduce delays and improve patient prognosis in NF. Further multicenter studies are needed to validate these findings and refine clinical protocols.</p><h2>Other Information</h2><p dir="ltr">Published in: European Journal of Trauma and Emergency Surgery<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00068-025-02816-8" target="_blank">https://dx.doi.org/10.1007/s00068-025-02816-8</a></p>2025-03-18T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00068-025-02816-8https://figshare.com/articles/journal_contribution/Time_to_diagnose_and_time_to_surgery_in_patients_presenting_with_necrotizing_fasciitis_a_retrospective_analysis/30393139CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303931392025-03-18T09:00:00Z |
| spellingShingle | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis Murad S. Alahmad (22457605) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Necrotizing fasciitis Time to diagnosis Time to intervention |
| status_str | publishedVersion |
| title | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| title_full | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| title_fullStr | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| title_full_unstemmed | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| title_short | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| title_sort | Time to diagnose and time to surgery in patients presenting with necrotizing fasciitis: a retrospective analysis |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Necrotizing fasciitis Time to diagnosis Time to intervention |