Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>)
<p>Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxi...
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2020
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| _version_ | 1864513563378319360 |
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| author | Roberta Giordo (299595) |
| author2 | Gheyath K. Nasrallah (2182598) Ola Al-Jamal (11721377) Panagiotis Paliogiannis (3439703) Gianfranco Pintus (91638) |
| author2_role | author author author author |
| author_facet | Roberta Giordo (299595) Gheyath K. Nasrallah (2182598) Ola Al-Jamal (11721377) Panagiotis Paliogiannis (3439703) Gianfranco Pintus (91638) |
| author_role | author |
| dc.creator.none.fl_str_mv | Roberta Giordo (299595) Gheyath K. Nasrallah (2182598) Ola Al-Jamal (11721377) Panagiotis Paliogiannis (3439703) Gianfranco Pintus (91638) |
| dc.date.none.fl_str_mv | 2020-05-28T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms21113838 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Resveratrol_Inhibits_Oxidative_Stress_and_Prevents_Mitochondrial_Damage_Induced_by_Zinc_Oxide_Nanoparticles_in_Zebrafish_em_Danio_rerio_em_/23650335 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biotechnology Chemical sciences Medicinal and biomolecular chemistry resveratrol nanoparticles ROS oxidative stress antioxidants mitochondria zebrafish zinc oxide |
| dc.title.none.fl_str_mv | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity. </p> <h2>Other Information</h2> <p>Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.3390/ijms21113838" target="_blank">https://doi.org/10.3390/ijms21113838</a> </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6bb2aa5f713fa177bcb6d126122bf6b8 |
| identifier_str_mv | 10.3390/ijms21113838 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23650335 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>)Roberta Giordo (299595)Gheyath K. Nasrallah (2182598)Ola Al-Jamal (11721377)Panagiotis Paliogiannis (3439703)Gianfranco Pintus (91638)Biomedical and clinical sciencesMedical biotechnologyChemical sciencesMedicinal and biomolecular chemistryresveratrolnanoparticlesROSoxidative stressantioxidantsmitochondriazebrafishzinc oxide<p>Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity. </p> <h2>Other Information</h2> <p>Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br> See article on publisher's website: <a href="https://doi.org/10.3390/ijms21113838" target="_blank">https://doi.org/10.3390/ijms21113838</a> </p>2020-05-28T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms21113838https://figshare.com/articles/journal_contribution/Resveratrol_Inhibits_Oxidative_Stress_and_Prevents_Mitochondrial_Damage_Induced_by_Zinc_Oxide_Nanoparticles_in_Zebrafish_em_Danio_rerio_em_/23650335CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/236503352020-05-28T00:00:00Z |
| spellingShingle | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) Roberta Giordo (299595) Biomedical and clinical sciences Medical biotechnology Chemical sciences Medicinal and biomolecular chemistry resveratrol nanoparticles ROS oxidative stress antioxidants mitochondria zebrafish zinc oxide |
| status_str | publishedVersion |
| title | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| title_full | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| title_fullStr | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| title_full_unstemmed | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| title_short | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| title_sort | Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (<em>Danio rerio</em>) |
| topic | Biomedical and clinical sciences Medical biotechnology Chemical sciences Medicinal and biomolecular chemistry resveratrol nanoparticles ROS oxidative stress antioxidants mitochondria zebrafish zinc oxide |