Comment on: “Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence”
<p dir="ltr">In an otherwise excellent paper, we find two methodological inaccuracies that might have overestimated the effect. First, the authors used a fixed-effect model for their meta-analysis. The fixed-effect model ignores any heterogeneity that may be present and gives a more...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| منشور في: |
2024
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| الملخص: | <p dir="ltr">In an otherwise excellent paper, we find two methodological inaccuracies that might have overestimated the effect. First, the authors used a fixed-effect model for their meta-analysis. The fixed-effect model ignores any heterogeneity that may be present and gives a more precise effect estimate, but it may not be generalizable. In cases where considerable heterogeneity is present, the random effects model can be used. This model takes into account the different populations on which the individual studies were conducted (Deeks et al., 2019). Second, the authors used funnel plots, Begg's test, and Egger's test to assess the risk of publication bias. As a rule of thumb, the Cochrane Handbook for Systematic Reviews of Interventions recommends against using tests for funnel plot asymmetry when the number of included studies is less than 10 (Page et al., 2019). Additionally, visual inspection of funnel plot asymmetry is quite subjective and prone to errors (Terrin et al.,2005). The Doi plot and the Luis Furuya–Kanamori index are more sensitive to publication bias with less than 10 included studies (Furuya-Kanamori et al., 2018 and do not suffer from the difficulty in interpretation as do funnel plots.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain and Behavior<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/brb3.3424" target="_blank">https://dx.doi.org/10.1002/brb3.3424</a></p> |
|---|