A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data
<p dir="ltr">Sodium glucose cotransporter-2 (SGLT2) inhibitors and loop diuretics can cause volume depletion. However, the long-term safety of the concurrent use of both agents has not been widely evaluated. We conducted a retrospective observational cohort study to evaluate the safe...
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2022
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| _version_ | 1864513549492027392 |
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| author | Alaa Rahhal (14150403) |
| author2 | Mostafa Najim (14150400) Asad Abusweireh (17191855) Masa Habra (17191858) Lenah Elgassim (17191861) Mohammed Omer Ali (17191864) Mhd Baraa Habib (11721774) Raad Tahtouh (14571110) Mohammad Al-Awad (17191867) Amer Hussien Aljundi (14150409) Ahmed Mahfouz (737928) Mohammed Thamer Ali (17191870) Wafer Dabdoob (17191873) Sumaya Alyafei (14147868) Nidal Asaad (284935) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Alaa Rahhal (14150403) Mostafa Najim (14150400) Asad Abusweireh (17191855) Masa Habra (17191858) Lenah Elgassim (17191861) Mohammed Omer Ali (17191864) Mhd Baraa Habib (11721774) Raad Tahtouh (14571110) Mohammad Al-Awad (17191867) Amer Hussien Aljundi (14150409) Ahmed Mahfouz (737928) Mohammed Thamer Ali (17191870) Wafer Dabdoob (17191873) Sumaya Alyafei (14147868) Nidal Asaad (284935) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alaa Rahhal (14150403) Mostafa Najim (14150400) Asad Abusweireh (17191855) Masa Habra (17191858) Lenah Elgassim (17191861) Mohammed Omer Ali (17191864) Mhd Baraa Habib (11721774) Raad Tahtouh (14571110) Mohammad Al-Awad (17191867) Amer Hussien Aljundi (14150409) Ahmed Mahfouz (737928) Mohammed Thamer Ali (17191870) Wafer Dabdoob (17191873) Sumaya Alyafei (14147868) Nidal Asaad (284935) |
| dc.date.none.fl_str_mv | 2022-10-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.cpcardiol.2021.100995 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_Comparative_Study_of_Safety_Outcomes_of_Sodium_Glucose_Cotransporter-2_Inhibitors_and_Loop_Diuretics_Among_Diabetic_Patients_Using_Real-world_Data/24340066 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Comparative Study sodium glucose cotransporter-2 Diabetic world Data |
| dc.title.none.fl_str_mv | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Sodium glucose cotransporter-2 (SGLT2) inhibitors and loop diuretics can cause volume depletion. However, the long-term safety of the concurrent use of both agents has not been widely evaluated. We conducted a retrospective observational cohort study to evaluate the safety of SGLT2 inhibitors with loop diuretics vs SGLT2 inhibitors alone among diabetic patients. The primary endpoint was a composite of volume-depletion adverse events at 1 month and 12 months. Of the 400 patients included, 98 received SGLT2 inhibitors with a loop diuretic and 302 received SGLT2 inhibitors alone. The concurrent use of SGLT2 inhibitors and loop diuretics was tolerated at 1 month; however, it resulted in a significant increase in volume-depletion events at 12 months (10.2% vs 1.7%; aHR = 7.03, 95% CI (1.80-27.37), <i>P</i>-value = 0.005). In conclusion, the long-term concurrent use of SGLT2 inhibitors and loop diuretics increases the risk of volume depletion, warranting frequent monitoring.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2021.100995" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2021.100995</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_6d43dc23c9b7175f009ef84743bf59ff |
| identifier_str_mv | 10.1016/j.cpcardiol.2021.100995 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24340066 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world DataAlaa Rahhal (14150403)Mostafa Najim (14150400)Asad Abusweireh (17191855)Masa Habra (17191858)Lenah Elgassim (17191861)Mohammed Omer Ali (17191864)Mhd Baraa Habib (11721774)Raad Tahtouh (14571110)Mohammad Al-Awad (17191867)Amer Hussien Aljundi (14150409)Ahmed Mahfouz (737928)Mohammed Thamer Ali (17191870)Wafer Dabdoob (17191873)Sumaya Alyafei (14147868)Nidal Asaad (284935)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesComparative Studysodium glucose cotransporter-2Diabeticworld Data<p dir="ltr">Sodium glucose cotransporter-2 (SGLT2) inhibitors and loop diuretics can cause volume depletion. However, the long-term safety of the concurrent use of both agents has not been widely evaluated. We conducted a retrospective observational cohort study to evaluate the safety of SGLT2 inhibitors with loop diuretics vs SGLT2 inhibitors alone among diabetic patients. The primary endpoint was a composite of volume-depletion adverse events at 1 month and 12 months. Of the 400 patients included, 98 received SGLT2 inhibitors with a loop diuretic and 302 received SGLT2 inhibitors alone. The concurrent use of SGLT2 inhibitors and loop diuretics was tolerated at 1 month; however, it resulted in a significant increase in volume-depletion events at 12 months (10.2% vs 1.7%; aHR = 7.03, 95% CI (1.80-27.37), <i>P</i>-value = 0.005). In conclusion, the long-term concurrent use of SGLT2 inhibitors and loop diuretics increases the risk of volume depletion, warranting frequent monitoring.</p><h2>Other Information</h2><p dir="ltr">Published in: Current Problems in Cardiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.cpcardiol.2021.100995" target="_blank">https://dx.doi.org/10.1016/j.cpcardiol.2021.100995</a></p>2022-10-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.cpcardiol.2021.100995https://figshare.com/articles/journal_contribution/A_Comparative_Study_of_Safety_Outcomes_of_Sodium_Glucose_Cotransporter-2_Inhibitors_and_Loop_Diuretics_Among_Diabetic_Patients_Using_Real-world_Data/24340066CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/243400662022-10-01T00:00:00Z |
| spellingShingle | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data Alaa Rahhal (14150403) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Comparative Study sodium glucose cotransporter-2 Diabetic world Data |
| status_str | publishedVersion |
| title | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| title_full | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| title_fullStr | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| title_full_unstemmed | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| title_short | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| title_sort | A Comparative Study of Safety Outcomes of Sodium Glucose Cotransporter-2 Inhibitors and Loop Diuretics Among Diabetic Patients Using Real-world Data |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Comparative Study sodium glucose cotransporter-2 Diabetic world Data |